Bone marrow T-cell subsets in patients with monoclonal gammopathies: Correlation with clinical stage and disease status

Haematologica

Volumn 82, Issue 1, 1997, Pages 43-46

  Corso, Alessandro ^a,b   Castelli, Guglielmo ^a   Pagnucco, Guido ^a   Lazzarino, Mario ^a   Bellio, Laura ^a   Klersy, Catherine ^b   Bernasconi, Carlo ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Bone marrow; Monoclonal gammopathies; Multiple myeloma; T cells

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN;

ADULT; AGED; ARTICLE; BONE MARROW BIOPSY; BONE MARROW CELL; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; BONE MARROW; CD4-CD8 RATIO; FEMALE; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; MULTIPLE MYELOMA; NEOPLASM STAGING; PARAPROTEINEMIAS; T-LYMPHOCYTE SUBSETS;

EID: 0031451379     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Clement LT, Grossi CE, Garland GL. Morphologic and phenotypic features of the subpopulation of Leu2+ that suppress cell differentiation. J Immunol 1984; 137:484-6.
2. Perri TR, Oken MM, Kay NE. Enhanced T cell suppression is directed toward sensitive circulating B cells in multiple myeloma. J Lab Clin Med 1982; 99:512-5.
3. Dianzani U, Pileri A, Boccadoro M, et al. Activated idiotype-reactive cells in suppressor/cytotoxic subpopulations of monoclonal gammopathies: correlation with diagnosis and disease status. Blood 1988; 72:1064-8.
4. Cimino G, Avvisati G, Amadori S, et al. High serum IL-2 levels are predictive of prolonged survival in multiple myeloma. Br J Haematol 1990; 75:373-7.
5. Lauria F, Foa R, Cavo M, et al. Membrane phenotype and functional behaviour of T lymphocytes in multiple myeloma: correlation with clinical stages of the disease. Clin Exp Immunol 1984; 56:653-8.
6. Mills KHG, Cawley JC. Abnormal monoclonal antibody-defined helper/suppressor T-cell subpopulations in multiple myeloma: relationship to treatment and clinical stage. Br J Haematol 1983; 53:271-5.
7. San Miguel JF, Caballero MD, Gonzales M, et al. T-cell subpopulations in patients with monoclonal gammopathies. Am J Hematol 1985; 20:333-8.
8. Pilarsky LM, Andrews EJ, Serra HM, Lensetter JA, Ruether BA, Mant MJ. Abnormalities in lymphocyte profile and specificity repertoire of patients with Waldenström's macroglobulinemia, multiple myeloma and IgM monoclonal gammopathy of undetermined significance. Am J Hematol 1989; 30:53-60.
9. San Miguel JF, Gonzales M, Gascon A, et al. Lymphoid subsets and prognostic factors in multiple myeloma. Br J Haematol 1992; 80:305-9.
10. Hicks MJ, Durie BGM, Slymen DJ. Low circulating T-helper cells in relapsing multiple myeloma. J Clin Lab Analysis 1989; 3:202-9.
11. Oken MM, Kay NE. T-cell subpopulations in multiple myeloma: correlation with clinical disease status. Br J Haematol 1981; 49:629-34.
12. San Miguel JF, Gonzales M, Castellano-Leones C, for the Cooperative Group for the Study of Monoclonal Gammopathies. T-cell subsets and myeloma cell mass. Am J Hematol 1987; 25:235-6.
13. Redoglia V, Boccadoro M, Battaglio S, Dianzani U, Massaia M, Pileri A. Multiple myeloma: altered CD4/CD8 ratio in bone marrow. Haematologica 1990; 75:129-31.
14. Durie BCG, Salmon SE. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment and survival. Cancer 1975; 36:842-54.
15. Janossy G, Prentice HG. T cell subpopulations, monoclonal antibodies and their therapeutic applications. Clin Haematol 1982; 11:631-60.
16. Janossy G, Tidman N, Papageogion ES, Kung PC, Goldstein G. Distribution of T lymphocyte subsets in the human bone marrow and thymus. An analysis with monoclonal antibodies. J Immunol 1981; 126:1608-13.
17. Mellsted H, Holm G, Petterson D, et al. T cell in monoclonal gammapathies. Scand J Hematol 1982; 29:57-64.
18. Massaia M, Dianzani U, Bianchi A, Camponi A, Boccadoro M, Pileri A. Immune dysregulation in monoclonal gammopathies. Bone Marrow Transplant 1989; 4 (suppl 1):165-7.
19. Massaia M, Pileri A. T cells in multiple myeloma: is this a reliable population to count on as antitumor effector cells? Leuk Lymphoma 1995; 17:63-70.
20. Ellenhorn JDJ, Schreiber H, Bluestone JA. Mechanism of tumor rejection in anti-CD3 monoclonal antibody-treated mice. J Immunol 1990; 144:2840-6.
21. + cells. Br J Haematol 1995; 90:625-32.