Valproate versus flunarizine in migraine prophylaxis: A randomized, double-open, clinical trial

Functional Neurology

Volumn 12, Issue 5, 1997, Pages 267-276

  Mitsikostas, Dimos Dimitris ^a,b   Polychronidis, Ioannis ^a  

^a ATHENS NAVAL HOSPITAL   (Greece)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Flunarizine; Hamilton scale; Migrane prophylaxis; Valproate

Indexed keywords

FLUNARIZINE; VALPROIC ACID;

ADOLESCENT; ADULT; ARTICLE; ASTHENIA; CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG RESPONSE; DRUG SAFETY; DRUG SCREENING; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; MAJOR CLINICAL STUDY; MALE; MIGRAINE; NAUSEA; PATIENT SELECTION; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; SOMNOLENCE;

ADULT; ANTICONVULSANTS; DOUBLE-BLIND METHOD; FEMALE; FLUNARIZINE; HUMANS; MALE; MIGRAINE DISORDERS; PSYCHIATRIC STATUS RATING SCALES; VALPROIC ACID;

EID: 0031450199     PISSN: 03935264     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Sorensen KV. Valproate: a new drug in migraine prophylaxis. Acta Neurol Scand 1988;78:346-348
2. Hering R, Kuritzky A. Sodium valproate in the treatment of cluster headache: an open clinical trial. Cephalalgia 1989;9:195-198
3. Mathew NT, Ali S. Valproate in the treatment of persistent chronic daily headache. An open label study. Headache 1991;31: 71-74
4. Hering R, Kuritzky A. Sodium valproate in the prophylactic treatment of migraine: a double-blind study versus placebo. Cephalalgia 1992;12:81-84
5. Hering R, Steiner TJ. Sodium valproate for the acute migraine attacks. Cephalalgia 1994;14:305-306
6. Jensen R, Brinck T, Olesen J. Sodium valproate has a prophylactic effect in migraine without aura: a triple-blind, placebo controlled crossover study. Neurology 1994; 44:647-651
7. Mathew NT, Saper JR, Silberstein SD et al. Migraine prophylaxis with divalproex. Arch Neurol 1995;52:281-286
8. Cutrer FM, Limmroth V, Ayata G, Moskowitz MA. Attenuation by valproate of c-fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicin. Br J Pharmacol 1995;116:3199-3204
9. A receptor-mediated effects of sodium valproate on dural plasma protein extravasation to substance P and trigeminal stimulation. Br J Pharmacol 1995; 116:1661-1667
10. Mitsikostas DD. The valproate mechanisms of action in migraine. Cephalalgia 1994; 14:465 (letter)
11. Mitsikostas DD, Sfikakis A, Papadopoulou-Daifotis Z, Varonos D. The effects of valproate in brain monoamines of juvenile rats after stress. Prog Neuropsychopharmacol Biol Psychiatry 1993;17:295-310
12. Papakostas Y, Daras M, Markianos M, Stefanis C. Increased prolactin response to thyrotropin releasing hormone during migraine attacks. J Neurol Neurosurg Psychiatry 1987;50:927-928
13. Mendenopoulos G, Manafi T, Logothetis I, Bostantjopoulou S. Flunarizine in the prevention of classical migraine: a placebo-controlled evaluation. Cephalalgia 1985;5: 31-37
14. Amery WK, Caers LI, Aerts TJL. Flunarizine, a calcium antagonist, in the prophylactic treatment of migraine. Headache 1985;25:249-254
15. Shimell CJ, Fritz VU, Levien SL. A comparative trial of flunarizine and propranolol in the prevention of migraine. S Afr Med J 1990;77:75-78
16. Leone M, Grazzi L, La Mantia L, Bussone G. Flunarizine and migraine: a review. Headache 1991;31:388-391
17. Gawel MJ, Kreeft J, Nelson RF, Simard D, Amott WS. Comparison of the efficacy and safety of flunarizine to propranolol in the prophylaxis of migraine. Can J Neurol Sci 1992;19:340-345
18. Tfelt-Hansen P, Welch KMA. Migraine: prioritizing prophylactic treatment. In: Olesen J, Tfelt-Hansen P, Welch KMA eds The Headaches. New York; Raven Press 1993:403-404
19. Welch KMA. Drug therapy of migraine. N Engl J Med 1993;11:1476-1483
20. Wauquier A, Ashton D, Marranas R. The effects of flunarizine in experimental models related to the pathogenesis of migraine. Cephalalgia 1985;5(Suppl 2):119-123
21. Toda N, Tfelt-Hansen P. Migraine: calcium antagonists. In: Olesen J, Tfelt-Hansen P, Welch KMA eds The Headaches. New York; Raven Press 1993:383-390
22. Overwerg J, Bibbie CD, Meijer JWA. Double-blind placebo controlled trial of flunarizine as add-on therapy in epilepsy. Epilepsia 1984;25:217-222
23. Todd PA, Benfield P. Flunarizine - a reappraisal of its pharmacological properties and therapeutic use in neurological disorders. Drugs 1989;38:481-499
24. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 1988;8(Suppl 7):1-96
25. Hamilton M. The assessment of anxiety rates by rating. Br J Med Psychol 1959;32: 50-55
26. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychology 1967;6:278-296
27. Silberstein SD. Divalproex sodium in headache: literature review and clinical guidelines. Headache 1996;36:547-555
28. Rascol A, Montastruc JL, Rascol O. Flunarizine versus pizotifen: a double-blind study in the prophylaxis of migraine. Headache 1986;26:83-85
29. Micheli FE, Pardal MMF, Giannaula R et al. Movement disorders and depression due to flunarizine and cinnarizine. Mov Dis 1989;4:139-146
30. Sorensen PS, Larsen BH, Rasmussen MJK. Flunarizine versus metoprolol in migraine prophylaxis: a double-blind, randomized parallel group study of efficacy and tolerability. Headache 1991;31:650-657
31. Centonze V, Magrone D, Vino M et al. Flunarizine in migraine prophylaxis: efficacy and tolerability of 5mg and 10 mg dose levels. Cephalalgia 1990;10:17-24
32. Bono G, Manzoni GC, Martucci N et al. Flunarizine in common migraine: Italian cooperative trial II. Long term follow-up. Cephalalgia 1985;5(Suppl 2):155-158
33. Leandri M, Parodi C, Bacigalupo F, Farini D. Long-term study on effectiveness of flunarizine in headache prophylaxis. Cephalalgia 1985;5(Suppl 3):556-557
34. Vijayan N, Spillane T. Valproic acid treatment of chronic daily headache. Headache 1995;35:540-543
35. Rothrock JF, Kelly NM, Brody ML, Golbeck A. A differential response to treatment with divalproex sodium in patients with intractable headache. Cephalalgia 1994;14:241-244
36. Glover V, Jarman J, Sandler M. Migraine and depression: biological aspects. J Psychiatr Res 1993;27:223-231
37. Williams DE, Raczynski JM, Domino J, Daving JP. Psychophysiological and MMPI personality assessment of headaches: an integrative approach. Headache 1993;33:149-154
38. Yin Fan A, Gu R-J, Zhou A. An MMPI control study: Chinese migraineurs during frequent headache attack intervals. Headache 1995;35:475-478