Cyclic Thrombocytopenia in a Patient Treated with Cyclosporine for Refractory Idiopathic Thrombocytopenic Purpura

American Journal of Hematology

Volumn 56, Issue 4, 1997, Pages 272-276

  Shirota, Tsunemichi ^a   Yamamoto, Hirobumi ^a   Fujimoto, Hiroaki ^a   Harada, Yoshimi ^a   Okada, Kiyoshi ^a   Uchida, Hiroyuki ^a   Roppongi, Hisashi ^a   Hayashi, Toru ^a  

^a TOKYO MEDICAL UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cyclic thrombocytopenia; Cyclosporine A; Idiopathic thrombocytopenic purpura

Indexed keywords

CYCLOSPORIN; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENT;

ADULT; ARTICLE; BONE MARROW CELL; CASE REPORT; CHEMICALLY INDUCED DISORDER; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOLOGY; MEGAKARYOCYTE; PATHOLOGY; PLOIDY; THROMBOCYTE; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ADULT; BLOOD PLATELETS; BONE MARROW CELLS; CYCLOSPORINE; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENTS; MEGAKARYOCYTES; PLATELET COUNT; PLOIDIES; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; THROMBOCYTOPENIA;

EID: 0031450124     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8652(199712)56:4<272::AID-AJH13>3.0.CO;2-B     Document Type: Article

References (18)

1. Berchtold P, McMillan R: Therapy of chronic idiopathic thrombocytopenic purpura in adults. Blood 74:2309, 1989.
2. George JN, El-Harake MA, Raskob GE: Chronic idiopathic thrombocytopenic purpura. New Engl J Med 331:1207, 1994.
3. Orosz CG, Fidelus RK, Roopenian DC, Widmer MB, Ferguson RM, Bach FH: A new immunosuppressive mechanism for Cyclosporin-A demonstrated with cloned T-lymphocytes. Transplant Proc 15:1927, 1983.
4. Bendzen K, Peterson J: Effect of Cyclosporin A (CyA) on the immune response. CyA competitively inhibits the function of monocytes/ macrophage-derived T-lymphocyte-activating factors. Immunol Lett 5:331, 1982.
5. Matsumura O, Kawashima Y, Kato S, Sanaka T, Teraoka S, Kawai T, Honda H, Fichinoue S, Takahashi K, Toma H, Ota K, Sugino N: Therapeutic effect of cyclosporine in thrombocytopenia associated with autoimmune disease. Transplant Proc 20:317, 1988.
6. Cohen T, Cooney DP: Cyclic thrombocytopenia. Case report and review of literature. Scand J Haematol 12:9, 1974.
7. Cederblad G, Hahn L, Korsan-Bengtsen K, Pehrsson NG, Rybo G: Variations in blood coagulation, fibrinolysis, platelet function and various plasma proteins during the menstrual cycle. Haemostasis 6: 294, 1977.
8. Nagasawa T, Hasegawa Y, Kamoshita M, Ohtani K, Komeno T, Itoh T, Shinagawa A, Kojima H, Ninomiya H, Abe T: Megakaryopoiesis in patients with cyclic thrombocytopenia. Br J Haematol 91:185, 1995.
9. Menitove JE, Pereira J, Hoffman R, Anderson T, Fried W, Aster RH: Cyclic thrombocytopenia of apparent autoimmune etiology. Blood 73: 1561, 1989.
10. Majumdar G, Slater NGP: Cyclic thrombocytopenia following splenectomy in an apparent case of idiopathic thrombocytopenic purpura. Clin Lab Haematol 15:233, 1993.
11. Yanabu M, Nomura S, Fukuroi T, Kawakatsu T, Kido H, Yamaguchi K, Suzuki M, Kokawa T, Yasunaga K: Periodic production of antiplatelet autoantibody directed against GP III a in cyclic thrombocytopenia. Acta Haematol 89:155, 1993.
12. Kosugi S, Tomiyama Y, Shiraga M, Kashiwagi H, Nakao H, Kanayama Y, Kurata Y, Matsuzawa Y: Cyclic thrombocytopenia associated with IgM anti-GP II b-III a autoantibodies. Br J Haematol 88:809, 1994.
13. George JN: Platelet IgG: Measurement, interpretation, and clinical significance. Prog Hemost Thromb 10:97, 1991.
14. He R, Reid DM, Jones CE, Shulman NR: Spectrum of Ig classes, specificities, and titers of serum antiglycoproteins in chronic idiopathic thrombocytopenic purpura. Blood 83:1024, 1994.
15. Kelsey PR, Schofield KP, Geary CG: Refractory idiopathic thrombocytopenic purpura(ITP) treated with cyclosporine. Br J Haematol 60: 197, 1985.
16. Schultz KR, Strahlendorf C, Warrier I, Ravindranath Y: Cyclosporin A therapy of immune-mediated thrombocytopenia in children. Blood 85: 1406, 1995.
17. Mihatsch MJ, Thiel G, Ryffel B: Hazards of Cyclosporine A therapy and recommendations for its use. J Autoimmun 1:533, 1988.
18. Velu TJ, Debusscher L, Strychkmans PA: Cyclosporine for the treatment of refractory idiopathic thrombocytopenic purpura. Eur J Haematol 38:95, 1987.