Effects of scopolamine and hippocampal lesions on negative patterning discrimination performance in rats

Behavioral Neuroscience

Volumn 111, Issue 6, 1997, Pages 1217-1227

  Richmond, M A ^a   Nichols, B P ^a   Deacon, R M J ^a   Rawlins, J N P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SCOPOLAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICHOLINERGIC EFFECT; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; COST BENEFIT ANALYSIS; DRUG EFFECT; INSTRUMENTAL CONDITIONING; LEARNING; NONHUMAN; PATTERN RECOGNITION; RAT; SPATIAL DISCRIMINATION; STIMULUS RESPONSE; TASK PERFORMANCE;

ANIMALS; CEREBRAL DECORTICATION; CHOICE BEHAVIOR; CONDITIONING, OPERANT; CUES; DISCRIMINATION LEARNING; HIPPOCAMPUS; MALE; MUSCARINIC ANTAGONISTS; N-METHYLSCOPOLAMINE; RATS; RATS, INBRED STRAINS; REACTION TIME; SCOPOLAMINE;

EID: 0031449573     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.111.6.1217     Document Type: Article

References (30)

1. Aggleton, J. P., Hunt, P. R., & Rawlins, J. N. P. (1986). The effects of hippocampal lesions upon spatial and non-spatial tests of working memory. Behavioural Brain Research, 19, 133-146.
2. Alvarado, M. C., & Rudy, J. W. (1995). Rats with damage to the hippocampal formation are impaired on the transverse-patterning problem but not on elemental discriminations. Behavioral Neuroscience, 109, 204-211.
3. Carli, M., Robbins, T. W., Evenden, J. L., & Everitt, B. J. (1983). Effects of lesions to ascending noradrenergic neurons on performance of a 5-choice serial reaction task in rats: Implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behavioural Brain Research, 9, 361-380.
4. Davidson, T. L., McKernan, M. G., & Jarrard, L. H. (1993). Hippocampal lesions do not impair negative patterning: A challenge to configural association theory. Behavioral Neuroscience, 107, 227-234.
5. Dunnett, S. B. (1985). Comparative effects of cholinergic drugs and lesions of nucleus basalis or limbria-fornix on delayed matching in rats. Psychopharmacology, 87, 357-363.
6. Eichenbaum, H., Otto, T., & Cohen, N. J. (1994). Two functional components of the hippocampal memory system. Behavioral and Brain Sciences, 17, 449-518.
7. Gallagher, M., & Holland, P. C. (1992). Preserved configural learning and spatial learning impairment in rats with hippocampal damage. Hippocampus, 2, 81-88.
8. Gray, J. A. (1982). The neuropsychology of anxiety: An enquiry into the functions of the septohippocampal system. Oxford, England: Oxford University Press.
9. Hagan, J. J., Tweedie, F., & Morris, R. G. M. (1986). Lack of task specificity and absence of posttraining effects of atropine on learning. Behavioral Neuroscience, 100, 483-493.
10. Herremans, A. H. J., Hijzen, T. H., Olivier, B., & Slangen, J. L. (1995). Cholinergic drug effects on a delayed conditional discrimination task in the rat. Behavioral Neuroscience, 109, 426-435.
11. Hindson, G. L. (1958). Toxic reaction after "kwells." British Medical Journal 1958(2), 636.
12. Jarrard, L. E., (1965). Hippocampal ablation and operant behaviour in the rat. Psychonomic Science, 2, 115-116.
13. Jarrard, L. E. (1968). Behavior of hippocampal lesioncd rats in home cage and novel situations. Physiology and Behavior, 3, 65-70.
14. Jarrard, L. E. (1989). On the use of ibotenic acid to lesion selectively different components of the hippocampal formation. Journal of Neuroscience Methods, 29, 251-259.
15. Lipska, B. K., Jaskiw, G. E., Chrapusta, S., Karoum, F., & Weinberger, D. R. (1992). Ibotenic acid lesion of the ventral hippocampus differentially affects dopamine and its metabolites in the nucleus accumbens and prefrontal cortex in the rat. Brain Research, 585, 1-6.
16. Moore, H., Dudchenko, P., Comer, K. S., Bruno, J. P., & Sarter, M. (1992). Central versus peripheral effects of muscarinic antagonists: The limitations of quarternary ammonium derivatives. Psychopharmacology, 108, 241-243.
17. Moran, P. M. (1992). Scopolamine deficits in negative patterning discrimination: Evidence for a role of the central cholinergic system in retention but not acquisition of non-spatial configural association learning. Behavioural Brain Research, 48, 187-197.
18. O'Keefe, J., & Nadel, L. (1978). The hippocampus as a cognitive map. Oxford, Hngland: Clarendon Press.
19. Olton, D. S., Becker, J. T., & Handelmann, G. E. (1979). Hippocampus, space and memory. Behavioral and Brain Sciences, 2, 313-365.
20. Paxinos, G., & Watson, C. (1986). The rat brain in stereotaxic coordinates (2nd ed.). New York: Academic Press.
21. Rawlins, J. N. P. (1985). Associations across time: The hippocampus as a temporary memory store. Behavioral and Brain Sciences, 8, 479-496.
22. Rawlins, J. N. P., & Bennett, R. C. (1980). A headholder for visually guided surgery in rats. Physiology and Behavior, 10, 415-416.
23. Rawlins, J. N. P., & Olton, D. S. (1982). The septo-hippocampal system and cognitive mapping. Behavioural Brain Research, 5, 331-358.
24. Rawlins, J. N. P., & Tsaltas, E. (1983). The hippocampus, time and working memory. Behavioural Brain Research, 10, 233-262.
25. Rudy, J. W., & Sutherland, R. J. (1989) The hippocampal formation is necessary for rats to learn and remember configural associations. Behavioural Brain Research, 34, 97-109.
26. Rudy, J. W., & Sutherland, R. J. (1995). Configural association theory and the hippocampal formation: An appraisal and reconfiguration. Hippocampus, 5, 375-389.
27. Squire, L. R. (1987). Memory and brain. Oxford, England: Oxford University Press.
28. Sutherland, R. J., & McDonald, R. J. (1990). Hippocampus, amygdala, and memory deficits in rats. Behavioural Brain Research, 37, 57-79.
29. Sutherland, R. J., & Rudy, J. W. (1989). Configural association theory: The role of the hippocampal formation in learning, memory and amnesia. Psychobiologv, 17, 129-144.
30. Whishaw, I. Q., & Tomie, J. (1991). Simple, conditional and configural learning using tactile and olfactory cues is spared in hippocampal rats: Implications for hippocampal function. Behavioral Neuroscience, 105, 787-797.