A hydroxypyridinone (CP94) enhances protoporphyrin IX formation in 5-aminolaevulinic acid treated cells

Journal of Photochemistry and Photobiology B: Biology

Volumn 41, Issue 1-2, 1997, Pages 136-144

  Bech, O ^a   Phillips, D ^b   Moan, J ^a   Macrobert, A J ^c  

^a INSTITUTE OF CANCER RESEARCH   (Norway)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

1,2 diethyl 3 hydroxypyridin 4 one; 5 aminolaevulinic acid; Cell survival; Iron chelators; Multidrug resistance; Photodynamic therapy; Protoporphyrin IX

Indexed keywords

AMINOLEVULINIC ACID; CD94 ANTIGEN; PROTOPORPHYRIN; PYRIDINOL;

ARTICLE; BLADDER CANCER; CANCER THERAPY; CELL LINE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IRON CHELATION; MULTIDRUG RESISTANCE; PHOTODYNAMIC THERAPY; PHOTOSENSITIVITY; PRIORITY JOURNAL; SKIN FIBROBLAST; SPECTROFLUOROMETRY;

EID: 0031448976     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1011-1344(97)00095-X     Document Type: Article

References (19)

1. A.M.R. Fisher, A.L. Murphree and C.J. Gomer, Clinical and Preclinical Photodynamic Therapy, Lasers Surg. Med., 17 (1995) 2-31.
2. G.H. Elder, Enzymatic defects in porphyria: An overview, Sem. Liver Dis., 2 (1982) 87-99.
3. K. Berg, H. Anholt, Ø. Bech and J. Moan, The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells, Br. J. Cancer, 74 (1996) 688-697.
4. J.C. Kennedy and R.H. Pottier, Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy, J. Photochem. Photobiol. B: Biol., 14 (1992) 275-292.
5. J. Regula, A.J. MacRobert, A. Gorchein, G.A. Buonaccorsi, S.M. Thorpe, G.M. Spencer, A.R.W. Hatfield and S.G. Bown, Photosensitisation and photodynamic therapy of oesophageal, duodenal and colorectal tumours using 5-aminolaevulinic acid induced protoporphyrin IX - a pilot study, Gut, 36 (1995) 67-75.
6. J.B. Porter, K.P. Hoyes, R.D. Abeysinghe, P.N. Brooks, E.R. Huehns and R.C. Hider, Comparison of the Subacute Toxicity and Efficacy of 3-Hydroxypyridin-4-One Iron Chelators in Overloaded and Nonoverloaded Mice, Blood, 78(10) (1991) 2727-2734.
7. H. Egami, Y. Takiyama, M. Cano, W.H. Houser and P.M. Pour, Establishment of hamster pancreatic ductal carcinoma cell line (PC-1) producing blood group-related antigens, Carcinogenesis, 10 (1989) 861-869.
8. Y. Takiyama, H. Egami and P.M. Pour, Expression of human tumourassociated antigens in pancreatic cancer induced in Syrian hamsters, Am. J. Pathol., 136 (1990) 707-715.
9. C.-W. Lin, J.C. Lin and G.R. Prout, Establishment and characterization of four human bladder tumour cell lines and sublines with different degrees of malignancy, Cancer Res., 45 (1985) 5070-5079.
10. F. McGovern, T. Kachel, S. Vijan, S. Schiff, C.-W. Lin and G.R. Prout, Jr., Establishment and characterization of a doxorubicin-resistant human bladder cancer cell line (MGH-U1R), J. Urol., 140 (1988) 410-414.
11. J.W. Floyd, C.-W. Lin and G.R. Prout, Jr., Multi-drug resistance of a doxorubicin-resistant bladder cancer cell line, J. Urol., 144 (1990) 169.
12. R.C. Hider, G. Kontoghiorghes and J. Silver, Pharmaceutical compositions, UK patent BG 2118176A, (1982) London, UK.
13. E.N. Dotsika and C.J. Sanderson, A fluorometric assay for determining cell growth in lymphocyte proliferation and lymphokine assays, J. Immunol. Meth., 105 (1987) 55-62.
14. J. Regula, B. Ravi, J. Bedwell, A.J. MacRobert and S.G. Bown, Photodynamic therapy using 5-aminolaevulinic acid for experimental pancreatic cancer - prolonged animal survival, Br. J. Cancer, 70 (1994) 248-254.
15. S. Granick, P. Sinclair, S. Sassa and G. Grieninger, Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition, J. Biol. Chem., 250 (1975) 9215-9225.
16. J. Westerlund, M. Pudek and W.E. Schreiber, A rapid and accurate spectrofluorometric method for quantification and screening of urinary porphyrins, Clin. Chem., 34 (1988) 345-351.
17. H.W. Lim, S. Behar and D. He, Effect of porphyrin and irradiation on heme biosynthetic pathway in endothelial cells, Photodermatol. Photoimmunol. Photomed., 10 (1994) 17-21.
18. D. Kessel and C. Erickson, Porphyrin photosensitization of multi-drug resistant cell types, Photochem. Photobiol., 55 (1992) 397-399.
19. D. Kessel, K. Woodburn, B.W. Henderson and C.K. Chang, Sites of photodamage in vivo and in vitro by a cationic porphyrin, Photochem. Photobiol., 62 (1995) 875-881.