Increased testosterone production in vitro by Leydig cells from rats with severe autoimmune orchitis

International Journal of Andrology

Volumn 20, Issue 6, 1998, Pages 339-346

  Suescun, M O ^a,b   Calandra, R S ^b,c   Lustig, L ^d  

^a Instituto Multidisciplinario de Biologia Celular   (Argentina)

^b FACULTAD DE CIENCIAS EXACTAS   (Argentina)

^c INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

^d UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Autoimmune orchitis; Leydig cells; Steroidogenesis; Testis; Testosterone

Indexed keywords

CHORIONIC GONADOTROPIN; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNE DISEASE; CELL ULTRASTRUCTURE; ELECTRON MICROSCOPY; LEYDIG CELL; MACROPHAGE; MALE; MICROSCOPY; MORPHOMETRICS; NONHUMAN; ORCHITIS; PRIORITY JOURNAL; RAT; STEROIDOGENESIS; TESTIS; TESTOSTERONE SYNTHESIS; TISSUE HOMOGENATE;

EID: 0031448037     PISSN: 01056263     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2605.1998.00076.x     Document Type: Article

References (40)

1. Aiman, J., Brenner, P. F. & Mac Donald, P. C. (1980) Androgen and estrogen production in elderly men with gynecomastia and testicular atrophy after mumps orchids. Journal of Clinical and Endocrinology Metabolism, 50, 380-386.
2. Aoki, A. & Fawcett, D. W. (1978) Is there a local feedback from the seminiferous tubules affecting activity of the Leydig cells? Biology of Reproduction, 19, 144-158.
3. Boujrad, N., Hochcream-de Raviers, M. T. & Carreau, S. (1995) Evidence for germ cell control of Sertoli cell function in three models of germ cell depletion in adult rats. Biology of Reproduction, 53, 1345-1352.
4. Christensen, A. K. & Peacock, K. C. (1980) Increase in Leydig cell number in the testis of adult rats treated chronically with an excess of chorionic gonadotropin. Biology of Reproduction, 22, 389-397.
5. op) Mice Results in Male Fertility Defects. Biology of Reproduction, 55, 310-317.
6. Dirami, G., Poulter, L. W. & Cooke, B. A. (1991) Separation and characterization of Leydig cells and macrophages from rat testes. Journal of Endocrinology, 130, 357-365.
7. Doncel, G. F., Di Paola, J. A. & Lustig, L. (1989) Sequential study of the histopathology and cellular and humoral immune response during the development of an autoimmune orchitis in Wistar rats. American Journal of Reproductive Immunology, 20, 44-51.
8. Ewing, L. L. & Zirkin, B. (1983) Leydig cell structure and steroidogenic function. Recent Progress in Hormone Research, 39, 599-635.
9. Gaytan, F., Bellido, C., Morales, C., Garcia, M., van Rooijen, N. & Aguilar, E. (1996) In vivo manipulaton (depletion vs. activation) of testicular macrophages: central and local effects. Journal of Endocrinology, 150, 57-65.
10. Huang, H. F., Zaidi, P., Nieschlag, E. (1984) Pituitary testicular interrelationships during germinal involution in the vitamin A deficient rat. Journal of Endocrinology, 100, 33-41.
11. Huthaniemi, I. (1994) Fetal testis - a very special endocrine organ. European Journal of Endocrinology, 130, 25-31.
12. Jansz, G. F. & Pomerantz, D. K. (1984) Fetal irradiation increases androgen production by dispersed Leydig cells of the rat. Journal of Andrology, 5, 344-350.
13. Kerr, J. B., Rich, K. A. & De Kretser, D. M. (1979) Alterations of the fine structure and androgen secretion of the interstitial cells in the experimentally cryptorchid rat testis. Biology of Reproduction, 20, 409-422.
14. Kerr, J. B. & Donachie, K. (1986) Regeneration of Leydig cells in unilaterally cryptorchid rats: evidence for stimulation by local testicular factors. Cell and Tissue Research, 245, 649-655.
15. Khan, S., Teerds, K. & Dorrington, J. (1992) Growth factor Requirements for DNA synthesis by Leydig cells from immature rat. Biology of Reproduction, 46, 335-341.
16. Kierszenbaum, A. L. (1995) Testicular disease and the biology of HIV injection in the male. In Renal and Urologic Aspects of HIV Infection. (eds P. L. Kimmel, J. S. Berns & J. H. Stein), pp. 307-328. Churchill Livingstone, New York.
17. Lefèvre, A., Saez, J. M. & Finaz, C. (1983) hCG responsiveness of purified Leydig cells from immature and mature rats. Hormone Research, 17, 114-120.
18. Lejeune, H., Chuzel, F., Thomas, T., Avallet, O., Habert, R., Durand, P. & Saez, J. (1996) Regulation paracrine des cellules de Leydig. Annales d'Endocrinologie (Paris), 57, 55-63.
19. Levy, H., Deane, H. W. & Rubin, B. L. (1959) Visualization of steroid 3β-ol dehydrogenase activity in tissues of intact and hypophysectomized rats. Endocrinology, 65, 932-943.
20. Lustig, L., Lourtau, L., Perez, R. & Doncel, G. F. (1993) Phenotypic characterization of testicular cell infiltrates in rats undergoing an autoimmune orchitis. International Journal of Andrology, 16, 279-284.
21. Mahi-Brown, C. A. (1994) Autoimmune orchitis. Immunology and Allergy Clinics of North America, 14, 787-802.
22. Mayerhofer, D., Mayerhofer, A. & Bartke, A. (1992) Isolation and culture of testicular macrophages from a seasonally breeding species, Phodopus sungarus: evidence for functional differences between macrophages from active and regressed testes. International Journal of Andrology, 15, 263-281.
23. Mendis-Hangama, S. M. L. C. (1996) Conditions affecting Leydig cells. In: The Leydig Cell (eds A. H. Payne, M. P. Hardy & L. D. Russell), pp. 712-716. Cache River Press. Clearwater, Florida.
24. Mori, H. & Christensen, A. K. (1980) Morphometric analysis of Leydig cells in the normal rat testis. Journal of Cell Biology, 84, 340-354.
25. Ojeifo, J. O., Byers, S. W., Papadopoulous, V. & Dym, M. (1990) Sertoli-cell secreted protein(s) stimulates DNA synthesis in purified rat Leydig cells in vitro. Journal of Reproduction and Fertility, 90, 93-108.
26. Qureshi, S. J. & Sharpe, R. M. (1992) Effect of selective germ cell depletion in vivo on subsequent in vitro responsiveness of isolated Leydig cells. In: 7th European Workshop on Molecular and Cellular Endocrinology of the Testis. Abstract 67 Castle Elman, Germany.
27. Rich, K. A. & De Kretser, D. M. (1979) Effect of fetal irradiation on testicular receptors and testosterone response to gonadotropin stimulation in adut rats. Journal of Andrology, 1, 343-352.
28. Rich, K. A., Kerr, J. A. & De Kretser, D. M. (1979) Evidence for Leydig cell dysfunction in rats with seminiferous tubule damage. Molecular and Cellular Endocrinology, 13, 123-135.
29. Risbridger, G. P., Kerr, J. B. & De Kretser, D. M. (1981) An evaluation of Leydig cell function and gonadotropin binding in unilateral and bilateral cryptorchidism evidence for local control of Leydig cell function by the seminiferous tubule. Biology of Reproduction, 24, 534-540.
30. Rulli, S. D., Gonzalez-Calvar, S. I., Campo, S. & Calandra, R. S. (1995) Effects of two non-steroidal antiandrogens on testicular function in prepubertal rats. Journal of Andrology, 16, 225-232.
31. Sato, K., Hirokawa, K. & Hatakeyama, S. (1981) Experimental allergic orchitis in mice. Histopathological and immunological studies. Virchows Archives (Pathology-Anatomy), 392, 147-158.
32. Sharpe, R. M., Cooper, I. & Doogan, D. G. (1984) Increase in Leydig cell responsiveness in the unilaterally cryptorchid rat testis and its relationship to the intratesticular levels of testosterone. Journal of Endocrinology, 102, 319-327.
33. Suescun, M. O., Gonzalez, S. I., Chiauzzi, V. A. & Calandra, R. S. (1985) Effects of induced hypoprolactinemia on testicular function during gonadal maturation in the rat. Journal of Andrology, 6, 77-82.
34. Suescun, M. O., Calandra, R. S. & Lustig, L. (1994) Alterations of testicular function after induced autoimmune orchitis in rats. Journal of Andrology, 15, 442-448.
35. Suescun, M. O., Calandra, R. S. & Lustig, L. (1996) Increase of in vitro testosterone production by Leydig cells of rats with experimental autoimmune orchitis: possible role of macrophages. In: 10th International Congress of Endocrinology. Program & abstracts, Vol. 1, pp. 2-542. San Francisco, USA.
36. Teerds, K. J., De Rooij, D. G., Rommerts, F. F. G., Van den Hurk, R. & Wensing, C. J. G. (1989) Stimulation of the proliferation and differentiation of Leydig cell precursors after the destruction of existing Leydig cells with ethane dimethyl sulphonate (EDS) can take place in the absence of LH. Journal of Andrology, 10, 472-477.
37. Tung, K. S. K. & Mahi-Brown, C. A. (1990) Autoimmune orchitis and oophoritis. Immunology Allergy Clinics of North America, 10, 199-214.
38. Turner, K. J., McKinnell, C., McLaren, T. T., Qureshi, S. J., Saunders, P. T. K., Foster, P. M. D. & Sharpe, R. M. (1996) Detection of germ cell-derived proteins in testicular interstitial fluid: potential for monitoring spermatogenesis in vivo. Journal of Andrology, 17, 127-136.
39. Yee, J. B. & Hutson, J. C. (1985) Effects of testicular macrophage-conditioned medium on Leydig cells in culture. Endocrinology, 116, 2682-2684.
40. Wu, N. & Murono, E. P. (1994) a Sertoli cell-secreted paracrine factor(s) stimulates proliferation and inhibits steroidogenesis of rat Leydig cells. Molecular and Cellular Endocrinology, 106, 99-109.