Therapy of myocardial stunning

Basic Research in Cardiology, Supplement

Volumn 92, Issue 2, 1997, Pages 30-31

  Heusch, G ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CALCIUM ANTAGONIST; FREE RADICAL; SUPEROXIDE DISMUTASE;

BLOOD PRESSURE; CONFERENCE PAPER; COST BENEFIT ANALYSIS; DOG; EXPERIMENTAL ANIMAL; HEART MUSCLE BLOOD FLOW; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART MUSCLE REPERFUSION; HEART OUTPUT; HUMAN; INOTROPISM; RABBIT; STUNNED HEART MUSCLE; TREATMENT INDICATION; TREATMENT OUTCOME;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIOXIDANTS; CALCIUM CHANNEL BLOCKERS; DOGS; HEART RATE; HUMANS; MYOCARDIAL CONTRACTION; MYOCARDIAL STUNNING; RABBITS; RATS; REACTIVE OXYGEN SPECIES;

EID: 0031447083     PISSN: 01759418     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (24)

1. Ambrosio G, Jacobus WE, Bergmann CA, Weisman HF, Becker LC (1987) Preserved high energy phosphate metabolic reserve in globally stunned hearts despite reduction of basal ATP content and contractility. J Mol Cell Cardiol 19: 953-964
2. Ambrosio G, Weisfeldt M, Jacobus W, Flaherty J (1987) Evidence for a reversible oxygen radical-mediated component of reperfusion injury: reduction by recombinant human superoxide dismutase administered at the time of reflow. Circulation 75: 282-291
3. Bolli R (1995) Common methodological problems and artifacts associated with studies of myocardial stunning. Basic Res Cardiol 90: 257-262
4. Bolli R (1991) Superoxide dismutase 10 years later: a drug in search of a use. J Am Coll Cardiol 18: 231-233
5. Bolli R, Zhu W-X, Myers ML, Hartley CJ, Roberts R (1985) Beta-adrenergic stimulation reverses postischemic myocardial dysfunction without producing subsequent deterioration. Am J Cardiol 56: 964-968
6. Du Toit EF, Opie LH (1992) Modulation of severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at the onset of reperfusion. Circ Res 70: 960-967
7. Ehring T, Baumgart D, Krajcar M, Hümmelgen M, Kompa S, Heusch G (1994) Attenuation of myocardial stunning by the ACE-inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins, but not nitric oxide. Circulation 90: 1368-1385
8. Ehring T, Böhm M, Heusch G (1992) The calcium antagonist nisoldipine improves the functional recovery of reperfused myocardium only when given before ischemia. J Cardiovasc Pharmacol 20: 63-74
9. Ferrari R, Curello S, Ceconi C, Cargnoni A, Pasini E, Visioli O (1993) Cardioprotection by nisoldipine: role of timing of administration. Eur Heart J 14: 1258-1272
10. Flaherty JT, Pitt B, Gruber JW, Heuser RR, Rothbaum DA, Burwell LR, George BS, Kereiakes DJ, Deitchman D, Gustafson N, Brinker JA, Becker LC, Mancini GBJ, Topol E, Werns SW (1994) Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction. Circulation 89: 1982-1991
11. Gorge G, Papageorgiou I, Lerch R (1990) Epinephrine-stimulated contractile and metabolic reserve in postischemic rat myocardium. Basic Res Cardiol 85: 595-605
12. Heusch G (1996) How should stunning be treated? Dial Cardiovasc Med 1: 35-39
13. Heusch G (1992) Myocardial stunning: a role for calcium antagonists during ischaemia? Cardiovasc Res 26: 14-19
14. Jeroudi MO, Triana FJ, Patel BS, Bolli R (1990) Effects of superoxide dismutase and catalase, given separately, on myocardial stunning. Am J Physiol 259: H889-H901
15. Przyklenk K, Kloner RA (1987) Acute effects of hydralazine and enalapril on contractile function of postischemic "stunned" myocardium. Am J Cardiol 60: 934-936
16. Przyklenk K, Kloner RA (1991) Calcium antagonists and stunned myocardium: importance for clinicians? Cardiovasc Drugs Ther 5: 947-952
17. Qui Y, Galinases M, Ferrari R, Cargnoni A, Ezrin A, Hearse DJ (1992) PEG-SOD improves postischemic functional recovery and antioxidant status in blood-perfused rabbit hearts. Am J Physiol 263: H1243-H1249
18. Qui Y, Hearse DJ (1992) Comparison of ischemic vulnerability and responsiveness to cardioplegic protection in crystalloid-perfused versus blood-perfused hearts. J Thorac Cardiovasc Surg 103: 960-968
19. Schäfer S, Linder C, Heusch G (1990) Xamoterol recruits an inotropic reserve in the acutely failing, reperfused canine myocardium without detrimental effects on its subsequent recovery. Naunyn Schmiedebergs Arch Pharmacol 342: 206-213
20. Schulz R, Guth BD, Pieper K, Martin C, Heusch G (1992) Recruitment of an inotropic reserve in moderately ischemic myocardium at the expense of metabolic recovery: a model of short-term hibernation. Circ Res 70: 1282-1295
21. Schulz R, Rose J, Martin C, Brodde OE, Heusch G (1993) Development of short-term myocardial hibernation: its limitation by the severity of ischemia and inotropic stimulation. Circulation 88: 684-695
22. Sheiban I, Tonni S, Benussi P, Martini A, Trevi GP (1993) Left ventricular dysfunction following transient ischaemia induced by transluminal coronary angioplasty. Beneficial effects of calcium antagonists against post-ischaemic myocardial stunning. Eur Heart J 14 (Suppl A): 14-21
23. Sheiban I, Tonni S, Chizzoni A, Marini A, Trevi G (1997) Recovery of left ventricular function following early reperfusion in acute myocardial infarction: a potential role of the calcium antagonist nisoldipine. Cardiovasc Drugs Ther 11: 5-16
24. Triana JF, Li X-Y, Jamaluddin U, Thornby JI, Bolli R (1991) Postischemic myocardial "stunning": Identification of major differences between the open-chest and the conscious dog and evaluation of the oxygen radical hypothesis in the conscious dog. Circ Res 69: 731-747