Twenty six-week intravenous toxicity study of MCI-186 in beagle dogs with a recovery period of 5-week

Japanese Pharmacology and Therapeutics

Volumn 25, Issue SUPPL. 7, 1997, Pages 79-104

  Dalgard, Dan W ^a   Koka, Mohan ^a   Miura, Minoru ^b   Tamura, Shigeru ^b  

^a UK   (United States)

^b MITSUBISHI CHEMICAL CORPORATION   (Japan)

Author keywords

Dog; Intravenous administration; MCI 186; Repeated dose toxicity

Indexed keywords

NORPHENAZONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATAXIA; BODY WEIGHT; BRAIN ISCHEMIA; BRAIN PROTECTION; CELL DAMAGE; CHEMICAL STRUCTURE; DOG; ELECTRON MICROSCOPY; ERYTHROCYTE COUNT; HEMATOCRIT; HEMOGLOBIN ANALYSIS; HISTOPATHOLOGY; LIPID PEROXIDATION; MIOSIS; NONHUMAN; SALIVATION;

EID: 0031446387     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

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4. Watanabe T et al : Protective effects of MCI-186 on cerebral ischemia; Possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 268: 1597-1604, 1994
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6. Nakagomi T et al : Effect of a new free radical scavenger, MCI-186, on experimental cerebral vasospasm. Sano K et al ed, Proceedings of the 4th International Conference on Cerebral Vasospasm. p141-142, University of Tokyo Press, 1990
7. Ando K et al : General pharmacological studies of 3-methyl-1-phenyl-2-pyrazolin-5-one(MCI-186), a novel radical scavenging agent. Jpn Pharmacol Ther 25 (Suppl 7) : s1723-1753, 1997