Genetics of renal mechanisms of primary hypertension: The role of adducin

Journal of Hypertension

Volumn 15, Issue 12 II, 1997, Pages 1567-1571

  Barlassina, Cristina ^a   Citterio, Lorena ^b   Bernardi, Luca ^b   Buzzi, Laura ^b   D'Amico, Marco ^b   Sciarrone, Teresa ^b   Bianchi, Giuseppe ^b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b NONE

Author keywords

Cytoskeleton; Genetic; Renal function; Sodium; Sodium transports

Indexed keywords

ADDUCIN;

BLOOD PRESSURE REGULATION; CAUCASIAN; CELL MEMBRANE TRANSPORT; CONFERENCE PAPER; DNA POLYMORPHISM; ESSENTIAL HYPERTENSION; GENETIC MODEL; HUMAN; ION TRANSPORT; KIDNEY FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; RAT;

EID: 0031445469     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199715120-00057     Document Type: Conference Paper

References (34)

1. Bianchi G, Fox U, Di Francesco GF, Giovannetti AM, Pagetti D: Blood pressure changes produced by kidney cross transplantation between spontaneously hypertensive rats and normotensive rats. Clin Sci Mol Med 1974, 6:76-88.
2. Fox U, Bianchi G: The primary role of the kidney in causing blood pressure differences in the Milan hypertensive strain (MHS) and normotensive rats. Clin Exp Pharmacol Physiol 1976, 3:71-74.
3. Kawabe K, Watanabe TX, Shiono K, Sokabe H: Influence of blood pressure of renal isografts between spontaneously hypertensive and normotensive rats utilizing the F1 hybrids. Jpn Heart J 1978, 19:886-894.
4. Rettig R, Folberth C, Stauss H, Kopf D, Waldherr R, Unger T: Role of the kidney in primary hypertension: a renal transplantation study in rats. Am J Physiol 1990, 257:F606-F611.
5. Dahl LK, Heine M, Thompson K: Genetic influence of the kidneys on blood pressure. Evidence from chronic renal homografts in rats with opposite predisposition to hypertension. Circ Res 1974, 40:94-101.
6. Guidi E, Bianchi G, Dallosta V, Cantaluppi A, Mandelli V, Vallino F, et al.: The influence of familial hypertension of the donor on the blood pressure and antihypertensive therapy of familial graft recipient. Nephron 1982, 30:318-323.
7. Guidi E, Menghetti D, Milani S, Montagnino G, Palazzi P, Bianchi G: Hypertension may be transplanted with the kidney in humans: a long term historical prospective follow-up of recipients grafted with kidneys coming from donors with or without hypertension in their families. J Am Soc Nephrol 1996, 7:1131-1138.
8. Lifton RP: Molecular genetics of human blood pressure variation. Science 1996, 272:676-680.
9. Cusi D: Genetic renal mechanisms of hypertension. Curr Opin Nephrol Hypertens 1997, 6:192-204.
10. Ferrari P, Bianchi G: Lessons from experimental genetic hypertension. In Hypertension. Pathophysiology, Diagnosis and Management. Edited by Laragh JH, Brenner BB. New York: Raven Press; 1995, 1:1261-1279.
11. Bianchi G, Baer PG, Fox U, Duzzi L, Pagetti D, Giovannetti AM: Changes in renin, water balance and sodium balance during development of high blood pressure in genetically hypertensive rats. Circ Res 1975, 36 (suppl I):1131-1136.
12. Salvati P, Pinciroli GP, Bianchi G: Renal function of isolated perfused kidneys from hypertensive (MHS) and normotensive (MNS) rats of the Milan strain at different ages. J Hypertens 1984, 2 (suppl 3):351-353.
13. Salvati P, Ferrario RG, Parenti P, Bianchi G: Renal function of isolated perused kidneys from hypertensive (MHS) and normotensive (MNS) rats of the Milan strain: role of calcium. J Hypertens 1987, 5:31-38.
14. Hanozet G, Parenti P, Salvati P: Presence of a potential-sensitive Na transport across renal brush-border membrane vesicles from rats of the Milan hypertensive strain. Biochim Biophys Acta 1985, 819:179-186.
15. Ferrandi M, Salardi S, Parenti P, Ferrari P, Bianchi G, Braw R, et al.: Na-K-Cl cotransporter mediated Rb fluxes in membrane vesicles from kidneys of normotensive and hypertensive rats. Biochim Biophys Acta 1990, 1021:13-20.
16. Melzi ML, Syren ML, Assael BM, Sereni F, Aperia A: Increased renal tubular Na-K-ATPase activity in Milan hypertensive rats in the prehypertensive period. Pediatr Nephrol 1991, 5:700-703.
17. Ferrari P, Ferrandi M, Toriello L, Canessa M, Bianchi G: Relationship between erythrocyte volume and sodium transport in the Milan hypertensive rat and age-dependent changes. J Hypertens 1987, 9:498-503.
18. Bianchi G, Ferrari P, Trizio D, Ferrandi M, Torielli L, Barber BR, et al.: Red cell abnormalities and spontaneous hypertension in the rat. Hypertension 1985, 7:319-325.
19. Ferrari P, Torielli L, Salardi S, Rizzo A, Bianchi G: Na-K-Cl cotransport in released ghosts from erythrocytes of the Milan hypertensive rats. Biochim Biophys Acta 1992, 111:111-119.
20. Salardi S, Saccardo B, Borsani G, Modica R, Ferrandi M, Tripodi G, et al.: Erythrocyte adducin differential properties in the normotensive and hypertensive rats of the Milan strain: characterization of spleen adducin m-RNA. Am J Hypertens 1989, 2:229-237.
21. Joshi R, Gilligan DM, Otto E, McLaughlin T, Bennet V: Primary structure and domain organization of human alpha and beta adducin. J Cell Biol 1991, 115:665-675.
22. Hughes CA, Bennet V: Adducin: a physical model with implications for function in assembly of spectrin-actin complexes. J Biol Chem 1995, 270:18990-18996.
23. Kuhlman PA, Hughes CA, Bennet V, Fowler VM: A new function for adducin. J Biol Chem 1996, 271:7986-7991.
24. Bianchi G, Tripodi G, Casari G, Salardi S, Barber BR, Garcia P, et al.: Two point mutations in the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci USA 1994, 91:3999-4003.
25. Tripodi G, Valtorta F, Toriello L, Chieregatti E, Salardi S, Tursolino L, et al.: Hypertension associated point-mutation in the adducin αand β subunits affect actin cytoskeleton and ion transport. J Clin Invest 1996, 97:2815-2822.
26. Ferrandi M, Salardi S, Bianchi G, Ferrari P: Hypertension related adducin polymorphism affects Na-K-ATPase activity. Hypertension 1996, 28:689.
27. Bianchi G, Cusi D, Gatti M, Lupi GP, Ferrari P, Barlassina C, et al.: A renal abnormality as a possible cause of 'essential' hypertension. Lancet 1979, i:173-177.
28. Bianchi G, Cusi D, Barlassina C, Lupi GP, Ferrari P, Plicotti GB, et al.: Renal dysfunction as a possible cause of essential hypertension in predisposed subjects. Kidney Int 1983, 23:870-875.
29. Cusi D, Niutta E, Barlassina C, Bollini P, Cesana B, Stella P, et al.: Erythrocyte Na-K-Cl cotransport and kidney function in essential hypertension. J Hypertens 1993, 11:805-813.
30. Casari G, Barlassina C, Cusi D, Zagato L, Muirhead R, Righetti M, et al.: Association of the α-adducin locus with essential hypertension. Hypertension 1995, 25:320-326.
31. Cusi D, Barlassina C, Azzani T, Casari G, Citterio L, Devoto M, et al.: Polymorphism of α-adducin and salt sensitivity in patients with essential hypertension. Lancet 1997, 349:1353-1357.
32. Lin B, Nasir J, McDonald H: Genomic organization of the human alpha-adducin gene and its alternately spliced isoforms. Genomics 1995, 25:93-99.
33. Weinberger MH, Miller JZ, Luft FC, Grim CE, Fineberg NS: Definition and characteristics of sodium sensitivity and blood pressure resistance. Hypertension 1986, 8 (suppl 2):127-134.
34. Lanzani C, Righetti M, Rivera R, Azzani T, Buzzi L, D'Amico L, et al.: Pressure-natriuresis relationship and α-adducin polymorphism in essential hypertension [abstract]. In Eighth European Meeting on Hypertension, Milan, 13-17 June 1997.