The vasoconstriction induced by endothelin‐1 is mediated only by etA receptors in mesenteric small resistance arteries of spontaneously hypertensive rats and Wistar Kyoto rats

Journal of Hypertension

Volumn 15, Issue 12, 1997, Pages 1653-1657

  Rizzoni, Damiano ^a   Porteri, Enzo ^a   Piccoli, Alfonso ^a   Castellano, Maurizio ^a   Bettoni, Giorgio ^a   Pasini, Giancarlo ^a   Agabiti Rosei, Enrico ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Endothelin; Endothelium; Spontaneously hypertensive rats; Vascular hypertrophy; Vascular resistance

Indexed keywords

2 [[2 [[2 [[(HEXAHYDRO 1H AZEPIN 1 YL)CARBONYL]AMINO] 4 METHYLPENTANOYL]AMINO] 3 (1 METHYL 1H INDOL 3 YL)PROPIONYL]AMINO] 3 (2 PYRIDYL)PROPIONIC ACID; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR AGONIST; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; SUCCINYLENDOTHELIN 1 [8-21][9 GLUTAMIC ACID 11,15 ALANINE];

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; HYPERTENSION; MESENTERIC ARTERY; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; RESISTANCE BLOOD VESSEL; SMOOTH MUSCLE CONTRACTILITY; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

EID: 0031445292     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/00004872-199715120-00068     Document Type: Article

References (27)

1. Endothelin [editorial]. Lancet 1991, i:79-81.
2. Lüscher TF, Seo B, Bühler FR: Potential role of endothelin in hypertension. Controversy on endothelin in hypertension. Hypertension 1993, 21:752-757.
3. Vanhoutte PM: Is endothelin involved in the pathogenesis of hypertension? Hypertension 1993, 21:747-751.
4. Schiffrin EL, Deng LY, Sventek P, Day R: Enhanced expression of endothelin-1 gene in severe human essential hypertension. J Hypertens 1997, 15:57-63.
5. Sventek P, Li JS, Grove K, Deschepper CF, Schiffrin EL: Vascular structure and expression of endothelin-1 gene in L-NAME-treated spontaneously hypertensive rats. Hypertension 1996, 27:49-55.
6. Webb DJ: Endogenous endothelin generation maintains vascular tone in humans. J Hum Hypertens 1995, 9:459-463.
7. A receptors predominate in the human vasculature and mediate constriction. J Cardiovasc Pharmacol 1995, 26 (suppl 3):S265-S267.
8. Miller VM, Michener SR: Modulation of contractions to and receptors for endothelins in canine veins. Am J Physiol 1995, 268:H345-H350.
9. Berthiaume N, Claing A, Yano M, D'Orleans-Juste P: Characterization of receptors for endothelins in the guinea pig mesenteric vasculature. J Cardiovasc Pharmacol 1995, 26 (suppl 3):S317-S319.
10. B receptor antagonists PD145065 on arteries, arterioles and veins in the cat hindlimbs. J Cardiovasc Pharmacol 1995, 26 (suppl 3):S211-S213.
11. B receptors in the arterial vasculature of the isolated canine liver. J Cardiovasc Pharmacol 1995, 26 (suppl 3):S204-S207.
12. Takase H, Mureau P, Lüscher TF: Endothelin receptor subtypes in small arteries. Studies with FR 139317 and bosentan. Hypertension 1995, 25:739-743.
13. Deng LY, Li JS, Schiffrin EL: Endothelial receptor subtypes in resistance arteries from humans and rats. Cardiovasc Res 1995, 29:532-535.
14. Sharifi AM, Schiffrin EL: Endothelin receptors mediating vasoconstriction in rat pressurized small arteries. Can J Physiol Pharmacol 1996, 78:934-939.
15. B receptors mediate contraction to endothelin-1 in renal artery of aging SHR. Effects of FR 139317 and bosentan. Hypertension 1995, 25:501-506.
16. Mulvany MJ, Halpern W: Contractile properties of small resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 1977, 41:19-26.
17. Mulvany MJ, Hansen PK, Aalkjær C: Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrowed lumen, a thickened media, and an increased number of smooth muscle cell layers. Circ Res 1978, 43:854-864.
18. Stasch JP, Hirth-Dietrich C, Frobel K, Wegener M: Prolonged endothelin blockade prevents hypertension and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats. Am J Hypertens 1995, 8:1128-1134.
19. B receptor. Biochem Biophys Res Commun 1992, 184:953-959.
20. Rizzoni D, Castellano M, Porteri E, Bettoni G, Muiesan ML, Agabiti-Rosei E: Delayed development of hypertension after short-term nitrendipine treatment. Hypertension 1994, 24:131-139.
21. Rizzoni D, Castellano M, Porteri E, Bettoni G, Muiesan ML, Cinelli A, et al.: Effects of low and high doses of fosinopril on the structure and function of resistance arteries. Hypertension 1995, 26:118-123.
22. Dohi Y, Lüscher TF: Endothelin in hypertensive resistance arteries: intraluminal and extraluminal dysfunction. Hypertension 1991, 18:543-549.
23. Clozel M: Endothelin sensitivity and receptor binding in aorta of spontaneously hypertensive rats. J Hypertens 1989, 7:913-917.
24. Deng LY, Schiffrin EL: Effect of antihypertensive treatment on response to endothelin of resistance arteries of hypertensive rats. J Cardiovasc Pharmacol 1993, 21:725-731.
25. Cargnelli G, Rossi GP, Bova S, Pessina C: In vitro vascular reactivity to endothelin: a comparison between young and old normotensive and hypertensive rats. Clin Exp Hypertens [A] 1990, 12:1437-1451.
26. Touyz RM, Deng LY, Li JS, Schiffrin EL: Differential effects of vasopressin and endothelin-1 on vascular contractile and calcium responses in pressurized small arteries from spontaneously hypertensive rats. J Hypertens 1996, 14:983-991.
27. Deng LY, Schiffrin EL: Effects of endothelin-1 and vasopressin on resistance arteries of spontaneously hypertensive rats. Am J Hypertens 1992, 5:817-822.