Automated gas chromatography/tandem mass spectrometry with on-line chemical derivatization for the determination of tebufelone and two metabolites in human plasma

Journal of Mass Spectrometry

Volumn 32, Issue 12, 1997, Pages 1290-1298

  Dobson, Roy L M ^a   Dirr, Mary Kay ^a   Merkt, Bonnie L ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

Chemical derivatization; Gas chromatography tandem mass spectrometry; Human plasma; Metabolites; Tebufelone

Indexed keywords

DRUG METABOLITE; PGE 1802413; PGE 6285825; TEBUFELONE; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATION; CAPILLARY GAS CHROMATOGRAPHY; CHEMICAL MODIFICATION; DRUG DETERMINATION; HUMAN; INSTRUMENTATION; MASS SPECTROMETER; PLASMA; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ASSAY; TANDEM MASS SPECTROMETRY;

ALKYNES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AUTOANALYSIS; CALIBRATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; INDICATORS AND REAGENTS; PHENOLS; REFERENCE STANDARDS; TRIMETHYLSILYL COMPOUNDS;

ILEX COOKII;

EID: 0031445187     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9888(199712)32:12<1290::AID-JMS587>3.0.CO;2-L     Document Type: Article

References (3)

1. R. L. M. Dobson, D. M. Neal, B. R. DeMark and S. R. Ward, Anal. Chem. 62, 1819 (1990).
2. R. L. M. Dobson, G. R. Keim and D. M. Neal, Biol. Mass Spectrom. 23, 75 (1994).
3. R. M. Kaffenberger, T. H. Eichhold and M. J. Doyle, J. Chromatogr. 505, 349 (1990).