Complete eradication of hepatitis C virus after interferon treatment for chronic hepatitis C

Italian Journal of Gastroenterology and Hepatology

Volumn 29, Issue 3, 1997, Pages 255-261

  De Mitri, M S ^a,c   Morsica, G ^b   Chen, C H ^a   Mele L ^a   Baccarini, P ^a   Chianese, R ^a   Piccinini, A ^a   Lazzarin, A ^a   Pisi, E ^a,b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Chronic hepatitis C; HCV genotype; HCV RNA eradication; Interferon; Liver histology; Viral load

Indexed keywords

ALPHA INTERFERON; VIRUS RNA;

ADULT; AGED; ARTICLE; CHRONIC HEPATITIS; FEMALE; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIREMIA; VIRUS LOAD;

ADULT; ANTIVIRAL AGENTS; DNA, VIRAL; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERONS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RNA, VIRAL; STATISTICS, NONPARAMETRIC; VIRAL LOAD;

EID: 0031444376     PISSN: 11258055     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989;224:359-62.
2. Kuo G, Choo QL, Alter HJ, Gitnick GL, Redeker AG, Purcell RH, et al. An assay for circulating antibodies to a major etiologic virus of human non-A non-B hepatitis. Science 1989;244:362-4.
3. Alter HJ, Purcell RH, Shih JW, Melpolder JC, Houghton M, Choo QL, et al. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A non-B hepatitis. N Engl J Med 1989;321:1494500.
4. Realdi G, Albert! A, Rugge M, Rigoli AM, Tremolada F, Schivazappa L, et al. Long-term follow up of acute and chronic non-A, non-B post-transfusion hepatitis: evidence of progression to liver cirrhosis. Gut 1982;23:270-5.
5. Colombo M, Kuo G, Choo QL, Donato MF, Del Ninno E, Tommasini MA, et al. Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. Lancet 1989;ii: 1006-8.
6. Gerber MA. Relation of hepatitis C virus to hepatocellular carcinoma. J Hepatol 1993;17 (Suppl. 3):S108-11.
7. De Mitri MS, Poussin K, Baccarini P, D'Errico A, Simon N, Grigioni W, et al. HCV-associated liver cancer without cirrhosis. Lancet 1995;345:413-5.
8. Davis G, Baiart L, Schiff ER, Lindsay K, Bodenheimer HC, Perrillo RP, et al. Treatment of chronic hepatitis C with recombinant interferon alpha: a multicenter randomized, controlled trial. N Engl J Med 1989;321:1501-6.
9. Di Bisceglie A, Martin P, Kassianides C, Lisker-Melman M, Murray L, Waggoner J, et al. Recombinant interferon alpha therapy for chronic hepatitis C: a randomized, double-blind, placebo-controlled trial. N Engl J Med 1989;321:1506-10.
10. Marcellin P, Boyer N, Giostra E, Degott C, Courouce AM, Degos F, et al. Recombinant human alpha interferon in patients with chronic non-A non-B hepatitis: a multicenter randomized controlled trial in France. Hepatology 1991;13:393-7.
11. Albert! A, Chemello L, Bonetti P, Casarin C, Diodati G, Cavalletto L, et al. Treatment with interferon(s) of community-acquired chronic hepatitis and cirrhosis type C. J Hepatol 1993;17 (Suppl. 3):S 123-6.
12. Hoofnagle JH, Di Bisceglie AM, Shindo M. Antiviral therapy of hepatitis C - present and future. J Hepatol 1993;17 (Suppl. 3): 130-6.
13. Chayama K, Saitoh S, Arase Y, Ikeda K, Matsumoto T, Sakay Y. Effect of interferon administration on serum hepatitis C virus RNA in patients with chronic hepatitis C. Hepatology 1991;13:1040-3.
14. Saracco G, Rosina F, Abate ML, Chiandussi L, Gallo V, Cerutti E, et al. Long-term follow-up of patients with chronic hepatitis C treated with different doses of interferon alpha 2b. Hepatology 1993;18,:1300-5.
15. Reichard O, Glaumann H, Fryden A, Norkrans G, Schvarcz R, Sonnerborg A, et al. Two-year biochemical, virological and histological follow-up in patients with chronic hepatitis C responding in a sustained fashion to interferon alfa-2b treatment. Hepatology 1995;21:918-22.
16. Shindo M, Di Bisceglie AM, Hoofnagle JH. Long-term follow-up of patients with chronic hepatitis C treated with alpha interferon. Hepatology 1992;6:1013-6.
17. Baiart LA, Perrillo R, Roddenberry J, Regenstein F, Shim K-S, Shieh YSC, et al. Hepatitis C RNA in liver of chronic hepatitis C patients before and after interferon alpha treatment. Gastroenterology 1993;104:1472-7.
18. Bartolome J, Castillo I, Quiroga JA, Navas S, Carreno V. Detection of hepatitis C virus RNA in serum and peripheral blood mononuclear cells. J Hepatol 1993;17 (Suppl. 3):S90-93.
19. Lau JY, Mizokami M, Ohno T, Diamond DA, Kniffen J, Davis GL. Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C. Lancet 1993;342:1208-9.
20. Romeo R, Pol S, Berthelot P, Brechot C. Eradication of hepatitis C virus RNA after alpha-interferon therapy. Ann Intern Med 1994;121:276-7.
21. Vento S, Concia E, Ferraro T. Lack of sustained efficacy of inteferon in patients with chronic hepatitis C. N Engl J Med 1996;334:1479-80.
22. Yoshioka K, Kakumu S; Wakita T, Ishikawa T, Itoh Y, Takayanagi M, et al. Detection of hepatitis C virus by polymerase chain reaction and response to interferon-alpha therapy: relationship to genotypes of hepatitis C virus. Hepatology 1992;16:293-9.
23. Tisminetzky S, Gerotto M, Pontisso P, Chemello L, Ruvoletto MG, et al. Genotypes of hepatitis C virus in Italian patients with chronic hepatitis C. Int Hepatol Commun 1994;2:105-12.
24. Kanal K, Kako M, Okamoto H. HCV genotypes in chronic hepatitis C and response to Interferon. Lancet 1992;339:1543.
25. Dusheiko G, Schmilovitz-Weiss H, Brown D, Mcomish F, Yap PL, Sherlock S, et al. Hepatitis C virus genotypes: an investigation of type specific differences in geographic origin and disease. Hepatology 1994;19:13-8.
26. Takada N, Takase S, Enomoto N, Takada A, Date T. Clinical background of the patients having different types of hepatitis C virus genomes. J Hepatol 1992;14:35-40.
27. Simmonds P, Holmes EC, Cha TA, Chan S-W, Mcomish F, Irvine B, et al. Classification of hepatitis C virus into six major genotypes and a series of subtypes by philogenetic analysis of the NS5 region. J Gen Virol 1993;74:2391-9.
28. Lau JY, Davis GL, Kniffen J, Qian K, Urdea MS, Chan CS, et al. Significance of serum hepatitis C virus RNA levels in chronic hepatitis C. Lancet 1993;341:1501-4.
29. Kobayashi Y, Watanabe S, Konishi M, Yokoi M, Kakehashi R, Kaito M, et al. Quantitation and typing of serum hepatitis C virus RNA in patients with chronic hepatitis C treated with interferonbeta. Hepatology 1993;18:1319-25.
30. Hino K, Sainokami S, Shimoda K, lino S, Wabg Y, Okamoto H, et al. Genotypes and titres of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C. J Med Virol 1994:42:299-305.
31. Yuki N, Hayashi N, Kasahara A, Hagiwara H, Takehara T, Oshita M, et al. Pre-treatment viral load and response to prolonged in-terferon-alpha course for chronic hepatitis C. J Hepatol 1995;22:457-63.
32. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981;l:431-5.
33. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994;19:1513-20.
34. Chomczynsky P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
35. Kwok S, Higuchi R. Avoing false positives with PCR. Nature 1989;339:237-8.
36. Morsica G, Novati R, Lazzarin A. Detection of hepatitis C virus RNA by methods using phenol-chloroform or silica particles. J Clin Microbiol 1995;33:2522-3.
37. Stuyver L, Rossau R, Wyseur A, Duhamel M, Vanderborght B, Van Heuverswyn H, et al. Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay. J Gen Virol 1993;74:1093-102.
38. Urdea MS, Horn T, Fultz TJ, Anderson M, Running JA, Hamren S, et al. Branched DNA amplification multimers for the sensitive, direct detection of human hepatitis viruses. Nucleic Acid Research Symposium Series, no. 24. Oxford: Oxford University Press, 1991:197-200.
39. Collins M, Zayati C, Detmer JJ, Daly B, Kolberg JA, Cha T-A, et al. Preparation and characterization of RNA standards for use in quantitative branched DNA hybridization assays. Anal Biochem 1995:226:120-9.
40. Kakumu S, Yoshika K, Tanaka K, Higashi Y, Kurokawa S, Hirofuji H, et al. Long-term carriage of hepatitis C virus with normal aminotransferase after interferon treatment in patients with chronic hepatitis C. J Med Virol 1993;41:65-70.
41. DC Mitri MS, lervese T, Pisi E, Morsica G, Lazzarin A. Virological patterns of hepatitis C virus in chronic hepatitis C virus with biochemical sustained response to interferon therapy. Hepatology 1996:23:1287-9.
42. Chemello L, Cavalletto L, Casarin C, Bonetti P, Bernardinello E, Pontisso P, et al. Persistent hepatitis C viremia predicts late relapse after sustained response to interferon-a in chronic hepatitis C. Ann Intern Med 1996;124:1058-60.
43. Kasahara A, Hayashi N, Hiramatsu N, Oshita M, Hagiwara H, Katajama K, et al. Ability of prolonged interferon treatment to suppress relapse after cessation of therapy in patients with chronic hepatitis C: A multicenter randomized controlled trial. Hepatology 1995:21:291-7.