Prevalence of double pre-beta lipoproteinemia in hyperlipidemic patients is influenced by gender, menopausal status, and ApoE phenotype

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 11, 1997, Pages 2630-2637

  Cohn, Jeffrey S ^a   Giroux, Louise Marie ^a   Fortin, Louis Jacques ^a   Davignon, Jean ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Agarose gel electrophoresis; Double pre beta lipoproteinemia; Triglyceride rich remnant lipoproteins

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADOLESCENT; ADULT; AGAR GEL ELECTROPHORESIS; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOUBLE PRE BETA LIPOPROTEINEMIA; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; HYPERLIPOPROTEINEMIA; HYPERTRIGLYCERIDEMIA; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; POSTMENOPAUSE; PREVALENCE; PRIORITY JOURNAL; SCHOOL CHILD; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0031444266     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.11.2630     Document Type: Article

References (19)

1. Gianturco SH, Bradley WA. Triglyceride-rich lipoproteins and their role in atherosclerosis. Curr Opin Lipidol. 1991;2:324-328.
2. Havel R. McCollum Award Lecture, 1993: triglyceride-rich lipoproteins and atherosclerosis - new perspectives. Am J Clin Nutr. 1994;59:795-799.
3. Harnsten A. The hemostatic system and coronary heart disease. Thromb Res, 1993;70:1-38.
4. Mahley RW, Rall SC Jr. Type III hyperlipoproteinemia (dysbetalipoproteinemia): the role of apolipoprotein E in normal and abnormal lipoprotein metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic Basis of Inherited Disease. New York, NY: McGraw-Hill Publishing Co; 1989:1195-1213.
5. Rall SC Jr, Mahley RW. The role of apolipoprotein E genetic variants in lipoprotein disorders. J Intern Med. 1992;231:653-659.
6. Carlson LA, Ericsson M. Quantitative and qualitative serum lipoprotein analysis, part 1: studies in healthy men and women. Atherosclerosis. 1975;21:417-433.
7. Carlson K, Carlson LA. Comparison of the behaviour of very low density lipoproteins of type III hyperlipoproteinemia on electrophoresis on paper and on agarose gel with a note on a late (slow) pre-β VLDL lipoprotein. Scand J Clin Lab Invest. 1975;655-660.
8. Pagnan A, Havel RJ, Kane JP, Kotite L. Characterization of human very low density lipoproteins containing two electrophoretic populations: double pre-beta lipoproteinemia and primary dysbetalipoproteinemia. J Lipid Res. 1977;18:613-622.
9. Manzato E, Pagnan A, Ziron L, Gasparotto A, Braggion M. Double pre-beta lipoprotein: isolation and characterization of the two populations of very low density lipoproteins by zonal ultracentrifugation. Arteriosclerosis. 1984;4:598-603.
10. Pagnan A, Zanetti G, Bonanome A, Biffanti S, Ehnholm C, Keso L, Lukka M. Apolipoprotein E polymorphism, serum lipids and occurence of "double pre-betalipoproteinemia' (DPBL) in subjects from two different populations. Atherosclerosis. 1987;65:23-28.
11. Zannis VI, Breslow JL, Utermann G, Mahley RW, Weisgraber KH, Havel RJ, Goldstein JL, Brown MS, Schonfeld G, Hazzard WR, Blum C. Proposed nomenclature of apoE isoproteins, apo E genotypes, and phenotypes. J Lipid Res. 1982;23:911-914.
12. Weisgraber KH, Innerarity TL, Mahley RW. Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to arginine-cysteine interchange at a single site. J Biol Chem. 1982;257:2518-2521.
13. Gregg RE, Zech LA, Schaefer EJ, Brewer HB Jr. Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E. Science. 1981;211:584-586.
14. Gregg RE, Zech LA, Schaefer EJ, Stark D, Wilson D, Brewer HB Jr. Abnormal in vivo metabolism of apolipoprotein E4 in humans. J Clin Invest. 1986;78:815-821.
15. Chung BH, Segrest JP. Resistance of a very low density lipoprotein subpopulation from familial dysbetalipoproteinemia to in vitro lipolytic conversion to the low density lipoprotein density fraction. J Lipid Res. 1983;24:1148-1159.
16. Ehnholm C, Mahley RW, Chappell DA, Weisgraber KH, Ludwig E, Witztum JL. Role of apolipoprotein E in the lipolytic conversion of β-very low density lipoproteins to low density lipoproteins in type III hyperlipoproteinemia. Proc Natl Acad Sci U S A. 1984;81:5566-5570.
17. Brenninkmeijer BJ, Stuyt PMJ, Demacker PNM, Stalenhoef AFH, Laar AV. Catabolism of chylomicron remnants in normolipidemic subjects in relation to the apoprotein E phenotype. J Lipid Res. 1987;28:361-370.
18. Weintraub MS, Eisenberg S, Breslow JL. Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. J Clin Invest. 1987;80:1571-1577.
19. Brown AJ, Roberts DCK. The effect of fasting triacylglyceride concentration and apolipoprotein E polymorphism on postprandial lipemia. Arterioscler Thromb. 1991;11:1737-1744.