Clonal origin of multiple lung cancers: K-ras and p53 mutations determined by nonradioisotopic single-strand conformation polymorphism analysis

Diagnostic Molecular Pathology

Volumn 6, Issue 4, 1997, Pages 179-184

  Lau, Derick H M ^a   Yang, Bangjie ^a   Hu, Ruide ^a   Benfield, John R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DNA sequencing; K ras; Nonradioisotopic single strand conformation polymorphism (SSCP); P53; Polymerase chain reaction (PCR); Synchronous lung cancers

Indexed keywords

ADULT; AGED; ARTICLE; CANCER STAGING; CASE REPORT; DIFFERENTIAL DIAGNOSIS; DNA SEQUENCE; FEMALE; GENE MUTATION; HUMAN; LUNG BIOPSY; LUNG CANCER; LUNG METASTASIS; ONCOGENE K RAS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; AGED; CARCINOMA, SMALL CELL; CLONE CELLS; DNA, NEOPLASM; FEMALE; GENES, P53; GENES, RAS; HISTOCYTOCHEMISTRY; HUMANS; LUNG NEOPLASMS; NEOPLASMS, MULTIPLE PRIMARY; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SEQUENCE ANALYSIS, DNA;

EID: 0031443667     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-199708000-00001     Document Type: Article

References (24)

1. Chung KY, Mukhopadhyay T, Kim J, et al. Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract. Cancer Res 1993;53:1676-83.
2. Deschamps C, Pairolero PC, Trastek VF, Payne WS. Multiple primary lung cancers: results of surgical treatment. J Thorac Cardiovasc Surg 1990;99:769-78.
3. Ferguson MK. Synchronous primary lung cancers. Chest 1993; 103:398S-400S.
4. Figlin R, Holmes EC, Turrisi AT. Non-small cell lung cancer. In: Haskell C, ed. Cancer Treatment. Philadelphia: W.B. Saunders Company. 1995;385-413.
5. Gabriella S, Miozzo M, Pastorino U, et al. Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions. Cancer Res 1995;55:135-40.
6. Gazdar AF. Molecular changes in preneoplastic bronchial epithelial lesions. Proc Am Ass Cancer Res 1994;35:690.
7. Guinee DG Jr, Travis WD, Trivers GE, et al. Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 serum antibodies and C-erbB-2 expression. Carcinogenesis 1995;16:993-1002.
8. Kishimoto Y, Murakami Y, Shiraishi M, et al. Abberration of the p53 tumor suppressor gene in human non-small cell carcinoma of the lung. Cancer Res 1992;52:4799-804.
9. Kraegel SA, Gumerlock PH, Dungworth DL, et al. K-ras activation in non-small cell lung cancer in the dog. Cancer Res 1992;52: 4724-27.
10. Lehman TA, Bennett WP, Metcalf RA, et al. p53 Mutations, ras mutations, and p53-heat shock protein complexes in human lung carcinoma cell lines. Cancer Res 1991;51:4090-96.
11. Minna JD. Tumor suppressor genes and oncogenes in lung cancer: Potential clinical applications. Advances Oncol 1996;12:3-7.
12. Mitsudomi T, Steinberg SM, Nau MM, et al. p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene 1992;7:171-80.
13. Nowell PC. The clonal evolution of tumor cell populations. Acquired genetic liability permits selection of variant sublines and underlies tumor progression. Science 1976;194:23-24.
14. Rodenhuis S, Slebos R, Evers S, et al. Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Cancer Res 1988;48:5738-41.
15. Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium. Cancer 1953;6:693-98.
16. Slebo RJC, Hruban RH, Dalesio O. Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung. J Natl Cancer Inst 1991;83:1024-27.
17. Sozzi G, Miozzo M, Donghi R, et al. Deletions of 17p and p53 mutations in preneoplastic lesions of the lung. Cancer Res 1992; 52:6079-82.
18. Tate JE, Mutter GL, Boynton KA, Crum CP. Monclonal origin of vulvar intraepithelial neoplasia and some vulvar hyperplasias. Am J Pathol 1997;150:315-22.
19. Vogelstein B, Fearon ER, Hamilton SR, Feinbury AP. Use of restriction fragment length polymorphism to determine the clonal origin of human tumors. Science 1985;227:642-43.
20. Wain JC, Wilkins SJ, Benfield JR, Smith SS. DNA methylation patterns in human lung carcinomas. Current Surgery 1986;43:489-92.
21. Wainscoat JS, Fey MF. Assessment of clonality in human tumors: A review. Cancer Res 1990;50:1355-60.
22. Wingo PA, Tong T, Bolden S. Cancer Statistics, 1996. Ca - A Cancer Journal for Clinicians 1995;45:8-21.
23. Worsham MJ, Wolman SR, Carey TE, Zarbo RJ, Benninger MS, Van Dyke DL. Common clonal origin of synchronous primary head and neck squamous cell carcinomas: analysis by tumor karyo-types and fluorescence in situ hybridization. Hum Pathol 1995;26: 251-56.
24. Worsham MJ, Wolman SR, Zarbo RJ. Molecular genetic finger-prints: clues to monoclonal origin of multifocal disease. Modern Pathol 1996;9:163-65.