Safe withdrawal of monotherapy for hypertension is poorly effective and not likely to reduce health‐care costs

Journal of Hypertension

Volumn 15, Issue 12, 1997, Pages 1519-1526

  Prasad, Neeraj ^a   Davey, Peter G ^a   Watson, Alec D ^a   Peebles, Lesley ^a   MacDonald, Thomas M ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Ambulatory blood pressure monitoring; Cost effectiveness; Hypertension; Treatment withdrawal

Indexed keywords

AMLODIPINE; ANTIHYPERTENSIVE AGENT; ATENOLOL; BENDROFLUMETHIAZIDE; BISOPROLOL; ENALAPRIL; HYDROCHLOROTHIAZIDE PLUS TRIAMTERENE; LISINOPRIL; NIFEDIPINE;

ADULT; AGED; ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD PRESSURE MONITORING; COMMUNITY CARE; COMORBIDITY; COST CONTROL; DRUG COST; DRUG WITHDRAWAL; ELECTROCARDIOGRAM; FEMALE; HEALTH CARE COST; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRIMARY MEDICAL CARE; PRIORITY JOURNAL;

EID: 0031443067     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/00004872-199715120-00021     Document Type: Article

References (28)

1. Helgeland A: Treatment of mild hypertension: a 5 year controlled drug trial: the Oslo Study. Am J Med 1980, 69:725-732.
2. Medical Research Council Working Party: MRC trial of treatment of mild hypertension: principal results. BMJ 1985, 291:97-104.
3. MacMahon SW, Cutler JA, Neaton JD, Furberg CD, Cohen JD, Kuller LH, et al.: Relationship of blood pressure to coronary and stroke morbidity and mortality in clinical trials and epidemiological studies. J Hypertens 1986, 4 (suppl 6):14-17.
4. Mancia G, Grassi G, Gregorini L, Bertinieri G, Parati G, Pomidossi G, et al.: Effects of blood pressure management by the doctor on patients' blood pressure and heart rate. Lancet 1983, ii:695-698.
5. Prasad N, MacFadyen RJ, MacDonald TM: Ambulatory blood pressure monitoring in hypertension. Q J Med 1996, 89:95-102.
6. Page IH, Duston HP: Persistence of normal blood pressure after discontinuing treatment in hypertensive patients. Circulation 1962, 25:433-436.
7. Dustan HP, Page IH, Tarazi RC, Frolich ED: Arterial pressure response to discontinuing antihypertensive drugs. Circulation 1968, 37:370-379.
8. Thurm RH, Smith WM: On resetting of ‘barostats’ in hypertensive patients. JAMA 1967, 201:301-304.
9. Veteran Administration Co-operative Study Group on Antihypertensive Agents: Return of elevated blood pressure after withdrawal of antihypertensive drugs. Circulation 1975, 51:1107-1113.
10. Boyle RM, Price ML, Hamilton M: Thiazide withdrawal in hypertension. J R Coll Physicians Lond 1979, 13:172-173.
11. Levinson PD, Khatri IM, Freis ED: Persistence of normal BP after withdrawal of drug treatment in mild hypertension. Arch Intern Med 1982, 142:2265-2268.
12. Fotherby MD, Potter JF: Possibilities for antihypertensive drug therapy withdrawal in the elderly. J Hum Hypertens 1994, 8:857-863.
13. Aylett MJ, Creighton P, Jachuck S, Newrick D, Evans A: Withdrawing antihypertensive drugs [letter]. Lancet 1994, 343:1512.
14. Maland LJ, Lutz LJ, Castle CH: Effect of withdrawing diuretic therapy on blood pressure in mild hypertension. Hypertension 1983, 5:539-544.
15. Coats AJS: Reproducibility or variability of casual and ambulatory blood pressure data: implications for clinical trials. J Hypertens 1990, 8 (suppl 6):S17-S20.
16. Coats AJS, Conway J, Somers VK, Isea JE, Sleight P: Ambulatory pressure monitoring in the assessment of antihypertensive therapy. Cardiovasc Drug Ther 1989, 3:303-311.
17. Perloff D, Sokolow M, Cowan R: The prognostic value of ambulatory blood pressures. JAMA 1983, 249:2792-2798.
18. Devereux RB, Pickering TG: Relationship between ambulatory and exercise blood pressure and cardiac structure. Am Heart J 1988, 116:1124-1133.
19. Pickering TG, James GD, Boddie C, Harshfield GA, Blank S, Laragh JH: How common is white coat hypertension? JAMA 1988, 259:225-228.
20. Devereux RB, Reicheck N: Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation 1977, 55:613-618.
21. Du X, Cruickshank K, McNamee R, Saraee M, Sourbutts J, Summers A, et al.: Case-control study of stroke and the quality of hypertension control in the north of England. BMJ 1997, 314:272-276.
22. Langford HG, Blaufox MD, Oberman A, Hawkins CN, Curb JD, Cutter GK, et al.: Dietary therapy slows the return of hypertension after stopping prolonged medication. JAMA 1985, 253:657-664.
23. Stamler R, Stamler J, Grimm R, Gosch F, Elmer P, Dyer A, et al.: Nutritional therapy for high blood pressure. Final report of a four-year randomized controlled trial - the hypertension control program. JAMA 1987, 257:1484-1491.
24. Rotmensch HH, Mendelevitch L, Silverberg DS, Liron M: Prescribing pattern of antihypertensive drugs in the community. J Hum Hypertens 1996, 10 (suppl 3):169-172.
25. Weinstein MC, Siegel JE, Gold MR, Kamlet MS, Russell LGB, for the Panel on Cost-Effectiveness in Health and Medicine: Recommendations of the panel on cost-effectiveness in health and medicine. JAMA 1996, 276:1253-1258.
26. Beltman FW, Heesen WF, Kok RHJ, Smit AJ, May JF, de Graf PA, et al.: Predictive value of ambulatory blood pressure shortly after withdrawal of antihypertensive drugs in primary care patients. BMJ 1996, 313:404-406.
27. Claxton K, Posnett J: An economic approach to clinical trial design and research priority-setting. Health Econ 1996, 5:513-524.
28. Meyers MG, Reeves RA, Oh PI, Joyner CD: Overtreatment of hypertension in the community? Am J Hypertens 1996, 9:419-425.