Expression of lung resistance-related protein (LRP) in non-small cell lung carcinomas of smokers and non-smokers and its predictive value for doxorubicin resistance

Anti-Cancer Drugs

Volumn 8, Issue 10, 1997, Pages 931-936

  Volm, Manfred ^a   Mattern, Jürgen ^a   Koomägi, Reet ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Immunohistochemistry; Lung resistance related protein; Non small cell lung carcinomas; Proliferation; Smoking

Indexed keywords

CYCLIN A; DOXORUBICIN; PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CIGARETTE SMOKING; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; NONHUMAN; NUDE MOUSE; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0031442337     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199711000-00003     Document Type: Article

References (20)

1. Volm M, Mattern J, Samsel B. Relationship of inherent resistance to doxorubicin, proliferation activity and expression of P-glycoprotein 170, and glutatathione S-transferase-π in human lung tumors. Cancer 1992; 70: 764-9.
2. Volm M, Mattern J. Expression of topoisomerase II, catalase, metallothionein and thymidylate synthase in human squamous cell lung carcinomas and their correlation with doxorubicin resistance and with patients smoking habits. Carcinogenesis 1992; 13: 1947-50.
3. Scheper RJ, Broxterman HJ, Scheffer GL, et al. Overexpression of a 110 kD vesicular protein in non-P-glycoprotein mediated multidrugresistance. Cancer Res 1993; 53: 1475-9.
4. Izquierdo MA, Shoemaker RH, Flens MJ, et al. Overlapping phenotypes of multidrug resistance among panels of human cancer cell lines. Int J Cancer 1996; 65: 230-7.
5. Izquierdo MA, Scheffer GL, Flens MJ, et al. Expression of non-P-glycoprotein multidrug resistance associated protein LRP in normal human tissue and tumors. Am J Pathol 1996; 148 877-87.
6. Schadendorf D, Makki A, Stahr C, et al. Membrane transport proteins associated with drug resistance expressed in human melanoma. Am J Pathol 1995; 147: 1545-2.
7. List AF, Spier CS, Grogan TM, et al. Overexpression of the major vault transporter lung resistance protein predicts treatment outcome in acute myeloid leukemia. Blood 1996; 87: 2464-9.
8. Dingemans A-MC, van Ark-Otte J, van der Valk P, et al. Expression of the human mayor vault protein LRP in human lung cancer samples and normal lung tissues. Ann Oncol 1996; 7: 625-30.
9. Izquierdo MA, van der Zee A, Vermorken JB, et al. Drug resistance-associated marker LRP for prediction of response to chemotherapy and prognosis in advanced ovarian carcinoma. J Natl Cancer Inst 1995; 87: 1230-7.
10. World Health Organization. Histological typing of lung tumors. Tumori 1981; 6: 253-72.
11. Carr DT, Mountain CF. Staging lung cancer. In: Strauss MJ, ed. Lung cancer. Clinical diagnosis and treatment. New York: Grune and Stratton 1977: 151-61.
12. Volm M, Mattern J, Stammler G, et al. Expression of resistance-related proteins in nephroblastoma after chemotherapy. Int J Cancer 1995; 63: 193-7.
13. Group for Sensitivity Testing of Tumors (KSST). In vitro short-term test to determine the resistance of human tumors to chemotherapy. Cancer 1981; 48: 2127-35.
14. Volm M, Drings P, Hahn EW, Mattern, J. Prediction of the clinical chemotherapeutic response of stage III lung adenocarcinoma patients by an in vitro short-term test. Br J Cancer 1988; 57: 198-200.
15. Khoo SK, Hurst T, Webb MJ. Clinical value of in vitro drug sensitivity testing based on short-term effects on DNA and RNA metabolism in ovarian cancer. J Surg Oncol 1989; 41: 201-5.
16. Cordon-Cardo C. Mutation of cell cycle regulators. Biological and clinical implications for human neoplasia (Review). Am J Pathol 1995; 147: 545-60.
17. Thorgeirsson SS, Huber BE, Sorrel S, Fojo A, Pastan I, Gottesman MM. Expression of the multidrug resistance gene in hepato-carcinogenesis and regenerating rat liver. Science 1987; 236: 1120-2.
18. Fairchild CR, Ivy SP, Rushmore T, et al. Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas. Proc Natl Acad Sci USA 1987; 84: 7701-5.
19. Volm M, Zerban H, Mattern J, Efferth T. Overexpression of P-glycoprotein in rat hepatocellular carcinomas induced with N-nitrosomorpholine. Carcinogenesis 1990; 11: 169-72.
20. Volm M, Mattern J, Samsel B. Overexpression of P-glycoprotein and glutathione S-transferase in resistant non-small cell lung carcinomas of smokers. Br J Cancer 1991; 64: 700-4.