Regulation of neurons and astrocytes by thrombin and protease nexin-1: Relationship to brain injury

Advances in Experimental Medicine and Biology

Volumn 425, Issue , 1997, Pages 67-75

  Cunningham, Dennis D ^a   Donovan, Frances M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEASE NEXIN I; PROTHROMBIN; THROMBIN; THROMBIN RECEPTOR; THROMBIN RECEPTOR ACTIVATING PEPTIDE;

ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BLOOD CLOTTING; BRAIN INJURY; CELL VIABILITY; EXTRACELLULAR MATRIX; GLIOSIS; HUMAN; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ASTROCYTES; BLOOD COAGULATION; BRAIN INJURIES; CARRIER PROTEINS; CELL SURVIVAL; HUMANS; NEURONS; RECEPTORS, CELL SURFACE; SERPINS; THROMBIN;

EID: 0031442099     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5391-5_7     Document Type: Article

References (27)

1. Chen, L. B., & Buchanan, J. M. (1975) Mitogenic Activity of Blood Components. Thrombin and Prothrombin. Proceedings of the National Academy of Sciences USA 72: 131-135.
2. Carney, D. H., & Cunningham, D. D. (1978) Role of specific cell surface receptors in thrombin-stimulated cell division. Cell 15: 1341-9.
3. Glenn, K. C., Carney, D. H., Fenton, J. II., & Cunningham, D. D. (1980) Thrombin active site regions required for fibroblast receptor binding and initiation of cell division. Journal of Biological Chemistry 255: 6609-16.
4. Vu, T. K., Hung, D. T., Wheaton, V. L, & Coughlin, S. R. (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64: 1057-68.
5. 2+ mobilization. FEBS Letters 288: 123-8.
6. Monard, D., Niday, E., Limat, A., & Solomon, F. (1983) Inhibition of protease activity can lead to neurite extension in neuroblastoma cells. Progressive Brain Research 54:359-364.
7. Guenther, J., Nick, H., & Monard, D. (1985) A glia-derived neurite-promoting factor with protease inhibitory activity. EMBO Journal 4: 1963-6.
8. Gloor, S., Odink, K., Guenther, J., Nick, H., & Monard, D. (1986) A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins. Cell 47: 687-93.
9. Sommer, J., Gloor, S. M., Rovelli, G. F., Hofsteenge, J., Nick, H., Meier, R., & Monard, D. (1987) cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily. Biochemistry 26: 6407-10.
10. Gurwitz, D., & Cunningham, D. D. (1988) Thrombin modulates and reverses neuroblastoma neurite outgrowth. Proceedings of the National Academy of Sciences USA 85: 3440-4.
11. Cavanaugh, K., Gurwitz, D., Cunningham, D. D., & Bradshaw, R. (1990) Reciprocal modulation of astrocyte stellation by thrombin and Protease Nexin-1. Journal of Neurochemistry 54: 1735-1743.
12. Gurwitz, D., & Cunningham, D. D. (1990) Neurite outgrowth activity of Protease Nexin-1 on neuroblastoma cells requires thrombin inhibition. Journal of Cellular Physiology 142: 155-162.
13. Jalink, K., & Moolenaar, W. H. (1992) Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers. Journal of Cell Biology 118: 411-9.
14. Suidan, H. S., Stone, S. R., Hemmings, B. A., & Monard, D. (1992) Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors. Neuron 8: 363-75.
15. Cunningham, D. D., Pulliam, L., & Vaughan, P. J. (1993) Protease nexin-1 and thrombin: injury-related processes in the brain. Thrombosis and Haemostasis 70: 168-171.
16. Vaughan, P. J., Pike, C. J., Cotman, C. W., & Cunningham, D. D. (1995) Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. Journal of Neuroscience 15:5389-5401.
17. Sochocka, E., Juurlink, B. H., Code, W. E., Hertz, V., Peng, L., & Hertz, L. (1994) Cell death in primary cultures of mouse neurons and astrocytes during exposure to and 'recovery' from hypoxia, substrate deprivation and simulated ischemia. Brain Research 638: 21-28.
18. Smith-Swintosky, V. L., Zimmer, S., Fenton, J. W. H., & Mattson, M. P. (1995) Protease Nexin-1 and Thrombin Modulate Neuronal Calcium Homeostasis and Sensitivity to Glucose Deprivation-Induced Injury. Journal of Neuroscience 15: 5840-5850.
19. Niclou, S., Suidan, H., Brown-Luedi, M., & Monard, D. (1994) Expression of the thrombin receptor mRNA in rat brain. Cellular and Molecular Biology 40: 421-428.
20. Weinstein, J. R., Gold, S. J., Cunningham, D. D., & Gall, C. M. (1995) Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA. Journal of Neuroscience 15: 2906-19.
21. Houenou, L. J., Turner, P. L., Linxi, L., Oppenheim, R. W., & Festoff, B. W. (1995) A Serine Protease Inhibitor, Protease Nexin 1, Rescues Motoneurons from Naturally Occuring and Axotomy-induced Cell Death. Proceedings of the National Academy of Sciences USA 92: 895-899.
22. Connolly, A. J., Ishihara, H., Kahn, M. L., Farese, R. V, & Coughlin, S. R. (1996) Role of the thrombin receptor in development and evidence for a second receptor. Nature 381: 516-519.
23. Choi, B. H., Suzuki, M., Kim, T., Wagner, S. L., & Cunningham, D. D. (1990) Protease nexin-1: localization in the human brain suggests a protective role against extravasated serine proteases. American Journal of Pathology 137: 741-747.
24. Hoffmann, M. C., Nitsch, C., Scotti, A. L., Reinhard, E., & Monard, D. (1992) The prolonged presence of Glia-derived Nexin, and endogenous protease inhibitor, in the hippocampus after ischemia-induced delayed neuronal death. Neuroscience 49: 397-408.
25. Nitsch, C., Scotti, A. L., Monard, D., Heim, C., & Sontag, K. H. (1993) The glia-derived protease nexin 1 persists for over 1 year in rat brain areas selectively lesioned by transient global ischaemia. European Journal of Neuroscience 5: 292-7.
26. Scotti, A. L., Monard, D., & Nitsch, C. (1994) Re-expression of glia-derived nexin/protease nexin 1 depends on mode of lesion-induction or terminal degeneration: observations after excitotoxin or 6-hydroxydopamine lesions of rat substantia nigra. Journal of Neuroscience Research 37: 155-68.
27. Vaughan, P. J., & Cunningham, D. D. (1993) Regulation of protease nexin-1 synthesis and secretion in cultured brain cells by injury related factors. Journal of Biological Chemistry 268: 3720-3727.