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Current Topics in Microbiology and Immunology
Volumn 229, Issue , 1997, Pages 33-44
Characteristics of somatic hypermutation of human immunoglobulin genes
Author keywords

[No Author keywords available]
Indexed keywords

ANTIBODY RESPONSE; B LYMPHOCYTE; GENE REARRANGEMENT; GERMINAL CENTER; HUMAN; HUMAN CELL; IMMUNIZATION; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; POINT MUTATION; PRIORITY JOURNAL; REVIEW; SOMATIC MUTATION;
EID: 0031441874     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review
Times cited : (5)
References (11)
  • 1
    • 0030071749 scopus 로고    scopus 로고
    • An immunoglobulin mutator that targets G -C pairs
    • Bachl J, Wabl M (1996) An immunoglobulin mutator that targets G -C pairs. Proc Natl Acad Sci USA 93:851-855
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 851-855
    • Bachl, J.1    Wabl, M.2
  • 2
    • 0026331458 scopus 로고
    • Maturation of the immune response in germinal centers
    • Berek C, Berger A, Apel M (1991) Maturation of the immune response in germinal centers. Cell 67:1121-1129
    • (1991) Cell , vol.67 , pp. 1121-1129
    • Berek, C.1    Berger, A.2    Apel, M.3
  • 3
    • 0027499308 scopus 로고
    • Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots
    • Betz AC, Rada C, Pannell R, Milstein C, Neuberger MS (1993a) Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc Natl Acad Sci USA 90:2385-2388
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2385-2388
    • Betz, A.C.1    Rada, C.2    Pannell, R.3    Milstein, C.4    Neuberger, M.S.5
  • 4
    • 0027227311 scopus 로고
    • Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes
    • Betz AG, Neuberger MS, Milstein C (1993b) Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today 14:405-411
    • (1993) Immunol Today , vol.14 , pp. 405-411
    • Betz, A.G.1    Neuberger, M.S.2    Milstein, C.3
  • 5
    • 0014019617 scopus 로고
    • Origin of antibody variation
    • Brenner S, Milstein C (1966) Origin of antibody variation. Nature 211:242-243
    • (1966) Nature , vol.211 , pp. 242-243
    • Brenner, S.1    Milstein, C.2
  • 6
    • 0026782875 scopus 로고
    • Generation and analysis of random point mutations in an antibody CDR2 sequence: Many mutated antibodies lose their ability to bind antigen
    • Chen C, Roberts VA, Rittenberg MB (1992) Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen. J Exp Med 176:855-866
    • (1992) J Exp Med , vol.176 , pp. 855-866
    • Chen, C.1    Roberts, V.A.2    Rittenberg, M.B.3
  • 8
    • 0024362047 scopus 로고
    • The role of somatic hypermutation in the generation of antibody diversity
    • French DL, Laskov R, Scharff MD (1989) The role of somatic hypermutation in the generation of antibody diversity. Science 244:1152-1157
    • (1989) Science , vol.244 , pp. 1152-1157
    • French, D.L.1    Laskov, R.2    Scharff, M.D.3
  • 9
    • 0023107028 scopus 로고
    • Patterns of somatic mutations in immunoglobulin variable genes
    • Golding GB, Gearhart PJ, Glickman BW (1987) Patterns of somatic mutations in immunoglobulin variable genes. Genetics 115:169-177
    • (1987) Genetics , vol.115 , pp. 169-177
    • Golding, G.B.1    Gearhart, P.J.2    Glickman, B.W.3
  • 10
    • 0031202137 scopus 로고    scopus 로고
    • Telomerase is upregulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro
    • Hu B, Lee S, Marin E, Ryan D, Insel R (1997) Telomerase is upregulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro. J Immunol 159:1068-1071
    • (1997) J Immunol , vol.159 , pp. 1068-1071
    • Hu, B.1    Lee, S.2    Marin, E.3    Ryan, D.4    Insel, R.5

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.