Expression of the GABA(A) receptor α6 subunit in cultured cerebellar granule cells is developmentally regulated by activation of GABA(A) receptors

Journal of Neuroscience Research

Volumn 50, Issue 6, 1997, Pages 1053-1062

  Carlson, Berit X ^a   Belhage, Bo ^b   Hansen, Gert H ^b   Elster, Lisbeth ^a   Olsen, Richard W ^c   Schousboe, Arne ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Diazepam insensitive binding; GABA(A) receptor; Neurodifferentiation; Ro15 4513; THIP

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; GABOXADOL; MESSENGER RNA; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; CEREBELLUM; CONTROLLED STUDY; GENE EXPRESSION; GRANULE CELL; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NEWBORN; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; RAT;

ANIMALS; CELLS, CULTURED; CEREBELLUM; GABA AGONISTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; ISOXAZOLES; NEURONS; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 0031440955     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19971215)50:6<1053::AID-JNR17>3.0.CO;2-5     Document Type: Article

References (33)

1. Aldinio C, Balzano MA, Toffano G (1980): Ontogenetic development of GABA recognition sites in different brain areas. Pharmacol Res Commun 12:495-500.
2. A/benzodiazepine receptor complex in granule cells of the cerebellar cortex. Neuroscience 51:739-748.
3. Beattie CE, Siegel RE (1993): Developmental cues modulate GABAreceptor subunit mRNA expression in cultured cerebellar granule neurons. J Neurosci 13:1784-1792.
4. Belhage B, Damgaard I, Saederup E, Squires RF, Schousboe A (1991): High-and low-affinity GABA-receptors in cultured granule cells regulate transmitter release by different mechanisms. Neurochem Int 19:475-482.
5. Belhage B, Hansen GH, Elster L, Schousboe A (1997): Effects of γ-aminobutyric acid (GABA) on synaptogenesis and synaptic function. Perspec Dev Neurobiol 4:in press.
6. 6 subunit. Soc Neurosci Abstr 19:476.
7. Damgaard I, Trenkner E, Sturman JA, Schousboe A (1996): Effect of K+-and kainate-mediated depolarization on survival and functional maturation of GABAergic and glutamatergic neurons in cultures of dissociated mouse cerebellum. Neurochem Res 21:267-275.
8. Drejer J, Schousboe A (1989): Selection of a pure cerebellar granule cell culture by kainate treatment. Neurochem Res 14:751-754.
9. A receptor subunits in soma and processes of cerebellar granule cells: effects of maturation and a GABA agonist. Int J Devl Neurosci 13:417-428.
10. A receptor α 1 subunit mRNA in the rat brain. J Neurobiol 21:1169-1179.
11. A receptor δ subunit is selectively modulated by depolarization in cultured rat cerebellar granule neurons. J Neurosci 17:2391-2399.
12. Hansen GH, Meier E, Abraham J, Schousboe A (1987): Trophic effects of GABA on cerebellar granule cells in culture. In Redburn DA, Schousboe A (eds): "Neurotrophic Activity of GABA During Development." New York: Alan R. Liss, Inc., pp 109-138.
13. A receptor mRNAs and increases ligand binding. J Neurochem 62:2334-2337.
14. 3H]Ro15-4513 binding sites. Neuroscience 53:483-488.
15. A receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J Neurosci 12:1063-1076.
16. A receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J Neurosci 12:4151-4172.
17. A receptor selective for a behavioral alcohol antagonist. Nature 346:648-651.
18. A receptor channels. Ann Rev Neurosci 17:569-602.
19. 3H]Ro15-4513 binding to intact cultured cerebellar granule cells. Eur J Pharmacol 169:53-60.
20. Meier E,. Schousboe A (1982): Differences between GABA receptor binding to membranes from cerebellum during postnatal development and from cultured cerebellar granule cells. Dev Neurosci 5:546-553.
21. Meier E, Drejer J, Schousboe A (1984): GABA induces functionally active low-affinity GABA receptors on cultured cerebellar granule cells. J Neurochem 43:1737-1744.
22. A receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells. J Neurosci 16:103-114.
23. Ogurusu T, Shingai R (1996): Cloning of a putative γ-aminobutyric acid (GABA) receptor subunit p3 cDNA. Biochim Biophys Acta 1305:15-18.
24. A receptor stimulation. J Neurochem 68:631-639.
25. Schousboe A, Redburn DA (1995): Modulatory actions of gamma aminobutyric acid (GABA) on GABA type A receptor subunit expression and function. J Neurosci Res 41:1-7.
26. Schousboe A, Meier E, Drejer J, Hertz L (1989): Preparation of primary cultures of mouse (rat) cerebellar granule cells. In Shahar A, De Vellis J, Vernadakis A, Haber B (eds): "A Dissection and Tissue Culture Manual of the Nervous System." New York: Alan R. Liss, Inc., pp 203-206.
27. A receptors. Biochem J 310:1-9.
28. A receptor subtypes expressed in cerebellar granule cells: a developmental study. J Neurochem 62:2037-2044.
29. A receptor α1 and α6 subunit expression by a cyclic AMP-mediated signalling mechanism in cerebellar granule cells in primary culture. J Neurochem 67:434-437.
30. A receptor subtype that is insensitive to diazepam. J Pharmacol Exp Ther 257:1236-1242.
31. A receptor subunit mRNAs in the rat brain I. Telencephalon, diencephalon, mesencephalon. J Neurosci 12: 1040-1062.
32. Wolff JR, Joo F, Kasa P (1987): Synaptic, metabolic and morphogenetic effects of GABA in the superior cervical ganglion of rats. In Redburn DA, Schousboe A (eds): "Neurotrophic Activity of GABA During Development." New York: Alan R. Liss, Inc., pp 221-252.
33. A receptor subunit mRNA occurs only after cerebellar granule cell migration. Dev Brain Res 75:91-103.