The use of porphyrins for eradication of Staphylococcus aureus in burn wound infections

FEMS Immunology and Medical Microbiology

Volumn 19, Issue 4, 1997, Pages 307-314

  Orenstein, Arie ^a   Klein, Dov ^a   Kopolovic, Juri ^a   Winkler, Eyal ^a   Malik, Zvi ^b   Keller, Nathan ^a   Nitzan, Yeshayahu ^b  

^a SHEBA MEDICAL CENTER   (Israel)

^b BAR ILAN UNIVERSITY   (Israel)

Author keywords

Burn; Hemin; Porphyrin; Porphyrin complex; Staphylococcus aureus

Indexed keywords

DEUTEROPORPHYRIN IX; HEMIN; PORPHYRIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; BURN INFECTION; CONTROLLED STUDY; DRUG MIXTURE; GUINEA PIG; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; TOPICAL DRUG ADMINISTRATION; WOUND INFECTION;

ADMINISTRATION, TOPICAL; ANIMALS; BIOPSY; BURNS; COLONY COUNT, MICROBIAL; DEUTEROPORPHYRINS; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; DRUG RESISTANCE, MULTIPLE; GUINEA PIGS; HEMIN; INJECTIONS, INTRALESIONAL; PHOTOCHEMOTHERAPY; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TIME FACTORS; WOUND INFECTION;

EID: 0031440793     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(97)00097-7     Document Type: Article

References (26)

1. Heggers, J.P. and Robson, M.C. (1986) Infection control in burn patients. Clin. Plast. Surg. 13, 39-47.
2. Monafo, W.W. and Freedman, B. (1987) Topical therapy for burns. Surg. Clin. North Am. 67, 133-145.
3. Donati, L., Scamazzo, F., Gervasoni, M., Magliano, A., Stankov, B. and Fraschini, F. (1993) Infection and antibiotic therapy in 4000 burned patients treated in Milan, Italy, between 1976 and 1988. Burns 19, 345-348.
4. Dressler, D.P. and Skornik, W.A. (1970) Silver sulfadiamine and sulfamylon cream in the burned rat model: A comprehensive evaluation. Surgery 67, 644-649.
5. Inman, R.J., Snelling, F.T., Roberts, F.J., Shaw, K. and Boyle, J.C. (1984) Prospective comparison of silver sulfadiazine 1 percent plus chlorhexidine digluconate 0.2 percent (Silvazine) and silver sulfadiazine 1 percent (Flamazine) as prophylaxis against burn wound infection. Burns 11, 35-40.
6. Horton, R.C., Snelling, C.F.T. and Courtemanche, A.D. (1983) Influence of antibacterial prophylaxis on burn infection. J. Burn Care Rehabil. 4, 352-356.
7. Mulligan, M.E., Murray-Leisure, K.A., Ribner, B.S., Standiford, H.C., John, J.F., Korvick, J.A., Kauffman, C.A. and Yu, V.L. (1993) Methicillin-resistant Staphylococcus aureus: a consensus review of the microbiology, pathogenesis, and epidemiology with implications for prevention and management. Am. J. Med. 94, 313-328.
8. Nitzan, Y., Goshansky, S. and Malik, Z. (1983) Effect of photoactivated hematoprotein derivative on the viability of Staphylococcus aureus. Curr. Microbiol. 8, 279-284.
9. Nitzan, Y., Shainberg, B. and Malik, Z. (1987) Photodynamic effects of deuteroporphyrin on Gram positive bacteria. Curr. Microbiol. 15, 251-258.
10. Nitzan, Y., Shainberg, B. and Malik, Z. (1989) The mechanism of photodynamic inactivation of Staphylococcus aureus by deuteroporphyrin. Curr. Microbiol. 19, 265-269.
11. Venezio, F.R., DiVincenzo, C., Sherman, R., Reichman, M., Origitano, T.C., Tompson, K. and Reichman, D.H. (1985) Bactericidal effects of photoradiation therapy with hematoporphyrin derivative. J. Infect. Dis. 151, 166-169.
12. + and ionic balance during photodynamic inactivation of leukemic cells, erythrocytes and Staphylococcus aureus. Int. J. Biochem. 25, 1399-1406.
13. Nitzan, Y., Dror, R., Ladan, H., Malik, Z., Kimel, S. and Gottfried, V. (1995) Structure-activity relationship of porphyrins for photoinactivation of bacteria. Photochem. Photobiol. 62, 342-347.
14. Malik, Z., Ladan, H., Nitzan, Y. and Ehrenberg, B. (1990) The bactericidal activity of a deuteroporphyrin-hemin mixture on Gram-positive bacteria. A microbiological and spectroscopic study. J. Photochem. Photobiol. B Biol. 6, 419-430.
15. Kaufman, T., Lusthaus, S.N., Sagher, U. and Wexler, M.R. (1990) Deep partial skin thickness burns: a reproducible animal model to study burn wound healing. Burns 16, 13-16.
16. Bjornson, A.B., Bjornson, H.S., Lincoln, N.A. and Alemeier, W.A. (1984) Relative roles of burn injury, wound colonization, and wound infection in induction of alterations of complement function in a guinea pig model of burn injury. J. Trauma 24, 106-115.
17. Pruitt Jr., B.A. and McManus, A.T. (1992) The changing epidemiology of infection in burn patients. World J. Surg. 16, 57-67.
18. Heggers, J.P., Phillips, L.G., Boertman, J.A., Garethers, J., Wiengarten, M., Lentz, C.W., Hayden, J. and Robson, M.C. (1988) The epidemiology of methicillin-resistant Staphylococcus aureus in a burn center. J. Burn Care Rehabil. 9, 610-612.
19. Ronk, L.L. (1995) Surgical patients with multiantibiotic-resistant bacteria. AORN J. 61, 1023-1027.
20. Snyder, L.L., Wiebelhaus, P., Boon, S.E., Morin, R.A. and Goering, R. (1993) Methicillin resistant Staphylococcus aureus eradication in a burn center. J. Burn Care Rehabil. 14, 164-168.
21. Malik, Z., Ladan, H., Ehrenberg, B. and Nitzan, Y. (1991) Bacterial and viral photodynamic inactivation. In: Photodynamic Therapy - Basic Principles and Clinical Applications (Henderson, B.W. and Dougherty, T.J., Eds.), pp. 97-113. Marcel Dekker, New York.
22. Malik, Z., Hanania, J. and Nitzan, Y. (1990) New trends in photobiology (Invited Review). Bactericidal effects of photoactivated porphyrins - an alternative approach to antimicrobial drugs. J. Photochem. Photobiol. B Biol. 5, 281-293.
23. Fox Jr., C.L., Rao, T.N., Azmeth, R., Gandhi, S.S. and Modak, S. (1990) Comparative evaluation of zinc sulfadiazine and silver sulfadiazine in burn wound infection. J. Burn Care Rehabil. 11, 112-117.
24. Gray, J.H., Henry, D.A., Forbes, M., Germann, E., Roberts, F.J. and Snelling, C.F. (1991) Comparison of silver sulphadiazine 1 percent, silver sulphadiazine 1 percent plus chlorhexidine digluconate 0.2 percent and mafenide acetate 8.5 percent for topical antibacterial effect in infected full skin thickness rat burn wounds. Burns 17, 37-40.
25. Snelling, C.F. and Roberts, F.J. (1988) Comparison of 1% silver sulfadiazine with and without 1% chlorhexidine digluconate for topical antibacterial effect in the burnt infected rat. J. Burn Care Rehabil. 9, 35-40.
26. Snelling, C.F., Inman, R.J., Germann, E., Boyle, J.C., Foley, B., Kester, D.A., Fitzpatrick, D.J. and Warren, R.J. (1991) Comparison of silver sulfadiazine 1% with chlorhexidine digluconate 0.2% to silver sulfadiazine 1% alone in the prophylactic topical antibacterial treatment of burns. J. Burn Care Rehabil. 12, 13-18.