Ventilation and hypoxic ventilatory responsiveness in Chinese-Tibetan residents at 3,658 m

Journal of Applied Physiology

Volumn 83, Issue 6, 1997, Pages 2098-2104

  Curran, Linda S ^a   Zhuang, Jianguo ^b   Sun, Shin Fu ^b   Moore, Lorna G ^a,c  

^a UNIVERSITY OF COLORADO   (United States)

^b Tibet Institute of Medical Sciences   (China)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Control of breathing; High altitude; Hypoxic ventilatory depression

Indexed keywords

ALTITUDE; AMBIENT AIR; ARTICLE; BREATHING; CHEMOSENSITIVITY; CHINA; CONTROLLED STUDY; EXERCISE; HUMAN; HYPERCAPNIA; HYPOXIA; NORMAL HUMAN; PRIORITY JOURNAL; RESPIRATION CONTROL;

EID: 0031440001     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1997.83.6.2098     Document Type: Article

References (35)

1. Blangero, J., S. Williams-Blangero, M. J. Decker, K. P. Strohl, G. Brittenham, and C. M. Beall. Genetic analysis of hypoxic ventilatory response in a high-altitude Tibetan population (Abstract). Am. J. Phys. Anthropol. Suppl. 20: 66, 1995.
2. Byrne-Quinn, E., J. V. Weil, I. E. Sodal, G. F. Wiley, and R. F. Grover. Ventilatory control in the athlete. J. Appl. Physiol. 30: 91-98, 1971.
3. Collins, D. D., C. H. Scoggin, C. W. Zwillich, and J. V. Weil. Hereditary aspects of decreased hypoxic response. J. Clin. Invest. 62: 105-110, 1978.
4. Curran, L. S., J. G. Zhuang, T. S. Droma, L. Land, and L. G. Moore. Hypoxic ventilatory responses in Tibetan residents of 4400 m compared with 3658 m. Respir. Physiol. 100: 223-230, 1995.
5. Ergueta, J., H. Spielvogel, and L. Cudkowicz. Cardiorespiratory studies in chronic mountain sickness (Monge's syndrome). Respiration 28: 485-517, 1971.
6. Hackett, P. H., J. T. Reeves, C. D. Reeves, R. F. Grover, and D. Rennie. Control of breathing in Sherpas at low and high altitude. J. Appl. Physiol. 49: 374-379, 1980.
7. Hanson, M., and P. Kumar. Chemoreceptor function in the fetus and neonate. Adv. Exp. Med. Biol. 360: 99-108, 1994.
8. Hirshman, C. A., R. E. McCullough, and J. V. Weil. Normal values for hypoxic and hypercapnic ventilatory drives in man. J. Appl. Physiol. 38: 1095-1098, 1975.
9. Huang, S. Y., X. H. Ning, Z. N. Zhou, Z. Z. Gu, and S. T. Hu. Ventilatory function in adaptation to high altitude: studies in Tibet. In: High Altitude and Man. Bethesda, MD: Am. Physiol. Soc., 1984, p. 173-177. (Clin. Physiol. Ser.)
10. Huang, S. Y., D. P. White, N. J. Douglas, L. G. Moore, R. E. McCullough, J. V. Weil, and J. T. Reeves. Respiratory function in normal Chinese: comparison with Caucasians. Respiration 46: 265-271, 1984.
11. Kawakami, Y., T. Yoshikawa, A. Shida, Y. Asanuma, and M. Murao. Control of breathing in young twins. J. Appl. Physiol. 52: 537-542, 1982.
12. Kryger, M., R. E. McCullough, R. Doekel, D. Collins, J. V. Weil, and R. F. Grover. Excessive polycythemia of high altitude: role of ventilatory drive and lung disease. Am. Rev. Respir. Dis. 118: 659-666, 1978.
13. Lahiri, S. Carotid body chemoreception: mechanisms and dynamic protection against apnea. Biol. Neonate 65: 134-139, 1994.
14. Lahiri, S. Respiratory control in Andean and Himalayan high-altitude natives. In: High Altitude and Man. Bethesda, MD: Am. Physiol. Soc., 1984, p. 147-162. (Clin. Physiol. Ser.)
15. Lahiri, S., F. F. Kao, T. Velasquez, C. Martinez, and W. Pezzia. Irreversible blunted respiratory sensitivity to hypoxia in high altitude natives. J. Appl. Physiol. 6: 361-375, 1969.
16. Milledge, J. S., and S. Lahiri. Respiratory control in lowlanders and Sherpa highlanders at altitude. Respir. Physiol. 2: 310-322, 1967.
17. Monge, C. Chronic mountain sickness. Physiol. Rev. 23: 166-184, 1943.
18. Moore, G. C., C. W. Zwillich, J. D. Battaglia, E. K. Cotton, and J. V. Weil. Respiratory failure associated with familial depression of ventilatory response to hypoxia and hypercapnia. N. Engl. J. Med. 295: 861-865, 1976.
19. Moore, L. G., S. Zamudio, L. Curran-Everett, A. Torroni, L. B. Jorde, R. V. Shohet, Thupten, and T. Drolkar. Genetic adaptation to high altitude. In: Advances in Exercise and Sports Medicine, edited by S. Wood. New York: Dekker, 1994, vol. 76, p. 225-262. (Lung Biol. Health Dis. Ser.)
20. Mueller, W. H., R. Chakraborty, S. A. Barton, F. Rothhammer, and W. J. Schull. Genes and epidemiology in anthropologic adaptation studies: familial correlation in lung function in populations residing at different altitudes in Chile. Med. Anthropol. Summer: 367-384, 1980.
21. 2 saturation in Tibetan and Han infants born in Lhasa, Tibet. N. Engl. J. Med. 333: 1248-1252, 1995.
22. Pei, S. X., X. J. Chen, B. Z. Si Ren, Y. H. Liu, X. S. Cheng, E. M. Harris, I. S. Anand, and P. C. Harris. Chronic mountain sickness in Tibet. QJM 266: 555-574, 1989.
23. Read, D. J. A clinical method for assessing the ventilatory response to carbon dioxide. Aust. Ann. Med. 16: 20-32, 1966.
24. Regensteiner, J. G., and L. G. Moore. Migration of the elderly from high altitudes in Colorado. JAMA 253: 3124-3128, 1985.
25. Santolaya, S., S. Lahiri, R. T. Alfaro, and R. B. Schoene. Respiratory adaptation in the highest inhabitants and highest Sherpa mountaineers. Respir. Physiol. 77: 253-262, 1989.
26. Severinghaus, J. W. Hypoxic respiratory drive and its loss during chronic hypoxia. Clin. Physiol. 2: 57-79, 1972.
27. Sui, G. J., Y. H. Liu, X. S. Cheng, I. S. Anand, E. Harris, P. Harris, and D. Heath. Subacute infantile mountain sickness. J. Pathol. 155: 161-170, 1988.
28. Sun, S. F., S. Y. Huang, J. G. Zhuang, T. S. Droma, G. Banden, R. E. McCullough, R. G. Mccullough, A. Cymerman, J. T. Reeves, and L. G. Moore. Decreased ventilation and hypoxic ventilatory responsiveness are not reversed by nalaxone in Lhasa residents with chronic mountain sickness. Am. Rev. Respir. Dis. 142: 1294-1300, 1990.
29. Wallace, D. C. Mitochondrial diseases: genotype vs. phenotype. Trends Genet. 9: 128-133, 1993.
30. Weil, J. V., E. Bryne-Quinn, I. E. Sodal, G. F. Filley, and R. F. Grover. Acquired attenuation of chemoreceptor function in chronically hypoxic man at high altitude. J. Clin. Invest. 50: 186-195, 1971.
31. Weil, J. V., E. Bryne-Quinn, I. E. Sodal, W. O. Frisen, B. Underhill, G. F. Filley, and R. F. Grover. Hypoxic ventilatory drive in normal men. J. Clin. Invest. 49: 1061-1072, 1970.
32. Winslow, R. M., and C. Monge. Hypoxia, Polycythemia, and Chronic Mountain Sickness. Baltimore MD: John Hopkins University, 1987.
33. Wu, T. Y, T. F. Die, and K. S. Huo. An epidemiological study on high altitude disease at Qinghai-Xizang (Tibet) Plateau. Chin. J. Epidemiol. 8: 65-69, 1987.
34. Zhuang, J. G., T. S. Droma, S. F. Sun, C. Janes, R. E. McCullough, R. G. McCullough, A. Cymerman, S. Y. Huang, J. T. Reeves, and L. G. Moore. Hypoxic ventilatory responsiveness in Tibetan compared with Han residents of 3,658 m. J. Appl. Physiol. 74: 303-311, 1993.
35. 2 gradients in Tibetan than Han residents of Lhasa (3658 m). Respir. Physiol. 103: 75-82, 1996.