Frequent detection of hepatitis B virus X-gene DNA in hepatocellular carcinoma and adjacent liver tissue in hepatitis B surface antigen-negative patients

Digestive Diseases and Sciences

Volumn 42, Issue 11, 1997, Pages 2264-2269

  Takeuchi, Masaharu ^a   Fujimoto, Jiro ^a   Niwamoto, Hirofumi ^a   Yamamoto, Yoshihiro ^a   Okamoto, Eizo ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

HBsAg; Hepatitis B virus; Hepatocellular carcinoma; Polymerase chain reaction; Transactivator

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; VIRUS DNA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; HEPATITIS B VIRUS; HUMAN; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING; VIRUS DETECTION; VIRUS GENOME;

ADULT; AGED; BLOTTING, SOUTHERN; CARCINOMA, HEPATOCELLULAR; DNA PROBES; DNA, VIRAL; FEMALE; GENOME, VIRAL; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; TRANS-ACTIVATION (GENETICS);

EID: 0031439818     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018814700915     Document Type: Article

References (29)

1. Tiollais P, Pourcel C, Dejean A: The hepatitis B virus. Nature (London) 317:489-495, 1985
2. Beasley RP: Hepatitis B virus: the major etiology of hepatocellular carcinoma. Cancer 61:1942-1956, 1988
3. Robinson SW: Hepadnaviruses and hepatocellular carcinoma. Cancer Detect Prev 14:245-252, 1989
4. Ganem D, Varmus H: The molecular biology of the hepatitis B viruses. Annu Rev Biochem 56:651-693, 1987
5. Kekule AS, Lauer U, Weiss L, Luber B, Hofschneider PH: Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature 361:742-745, 1993
6. 1: Activation of NF-κB, selective inhibition by antioxidants and integral transmembrane localization. EMBO J 11:2991-3001, 1992
7. Okuda K: Hepatocellular carcinoma: Recent progress. Hepatology 15:948-963, 1992
8. Paterlini P, Brechot C: The detection of hepatitis B virus (HBV) in HBsAg negative individuals with primary liver cancer. Dig Dis Sci 36:1122-1129, 1991
9. Paterlini P, Poussin K, Kew M, Franco D, Brechot C: Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma. Hepatology 21:313-321, 1995
10. Blum HE, Galun E, Liang TJ, Weizsacker F, Wands JR: Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication. J Virol 65:1836-1842, 1991
11. Takahashi H, Fujimoto J, Hanada S, Isselbacher KJ: Acute hepatitis in rats expressing human hepatitis B virus transgenes. Proc Natl Acad Sci USA 92:1470-1474, 1995
12. Kwok S, Higuchi R: Avoiding false positives with PCR. Nature (London) 339:237-238, 1989
13. Liang TJ, Isselbacher KJ, Wands JR: Rapid identification of low level hepatitis B-related viral genome in serum. J Clin Invest 84:1367-1371, 1989
14. Brechot C, Degos F, Lugassy C, Thiers V, Zafrani S, Franco D, Bismuth H, Trepo C, Benhamou J-P, Wands J, Isselbacher K, Tiollais P, Berthelot P: Hepatitis B virus DNA in patients with chronic liver disease and negative tests for hepatitis B surface antigen. N Engl J Med 312:270-276, 1985
15. Paterlini P, Gerken G, Nakajima E, Terre S, D'Errico A, Grigioni W, Nalpas B, Franco D, Wands J, Kew M, Pisi E, Tiollais P, Brechot C: Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary livercancers from patients negative for hepatitis B surface antigen. N Engl J Med 323:80-85, 1990
16. Diamantis ID, McGandy CE, Chen T-J, Liaw Y-F, Gudat F, Bianchi L: Detection of hepatitis B and C viruses in liver tissue with hepatocellular carcinoma. J Hepatol 20:405-409, 1994
17. Hino O, Tabata S, Hotta Y: Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA. Proc Natl Acad Sci USA 88:9248-9252, 1991
18. Hino O, Shows TB, Rogler CE: Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17; 18 translocation. Proc Natl Acad Sci USA 83:8338-8342, 1986
19. Wang J, Chenivesse X, Henglein B, Brechot C: Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature 343:555-557, 1990
20. Dejean A, Bougueleret L, Grzeschik K-H, Tiollais P: Hepatitis B virus integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. Nature 322:70-72, 1986
21. Shirakata Y, Kawada M, Fujiki Y, Sano H, Oda M, Yaginuma K, Kobayashi M, Koike K: The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells. Jpn J Cancer Res 80:617-621, 1989
22. Hohne M, Schaefer S, Seifer M, Feitelson MA, Paul D, Gerlich WH: Malignant transformation of immortalized transgenic hepatocytes after transaction with hepatitis B virus DNA. EMBO J 4:1137-1145, 1990
23. Seto E, Mitchell PJ, Yen TSB: Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors. Nature 344:72-74, 1990
24. Kim C-M, Koike K, Saito I, Miyamura T, Jay G: HBx gene of hepatitis B virus induces livercancer in transgenic mice. Nature 351:317-320, 1991
25. Shiratori Y, Shiina S, Imamura M, Kato N, Kanai F, Okudaira T, Teratani T, Tohgo G, Toda N, Ohashi M, Ogura K, Niwa Y, Kawahe T, Omata M: Characteristic difference of hepatocellular carcinoma between hepatitis B- and C-viral infection in Japan. Hepatology 22:1027-1033, 1995
26. Edamoto Y, Tani M, Kurata T, Abe K: Hepatitis C and B virus infections in hepatocellular carcinoma. Canter 77:1787-1791, 1996
27. Tsukuma II, Hiyama T, Tanaka S, Nakao M, Yabuuchi T, Kitamura T, Nakanishi K, Fujimoto I, Inoue A, Yamazaki H, Kawashima T: Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 328:1797-1801, 1993
28. Saito I, Miyamura T, Ohbayashi A, Harada H, Katayama T, Kikuchi S, Watanahe Y, Koi S, Onji M, Ohta Y, Choo QL, Houghton M, Kuo G: Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci USA 87:6547-6549, 1990
29. Brechot C: Hepatitis C virus: Molecular biology and genetic variability. Dig Dis Sci 41:6S-21S, 1996