A Saccharomyces cerevisiae mitochondrial DNA fragment activates Reg1p-dependent glucose-repressible transcription in the nucleus

Current Genetics

Volumn 32, Issue 6, 1997, Pages 389-398

  Santangelo, George M ^a   Tornow, Joanne ^a  

^a University of Southern Mississippi   (United States)

Author keywords

GC clusters; Glucose repression; Mitochondrial regulation; Reg1p; Saccharomyces cerevisiae

Indexed keywords

DNA FRAGMENT; MITOCHONDRIAL DNA; NUCLEAR FACTOR;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; DNA SEQUENCE; GENOME; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION INITIATION;

BASE SEQUENCE; CELL NUCLEUS; DNA, FUNGAL; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GLUCOSE; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHOPROTEIN PHOSPHATASE; PROMOTER REGIONS (GENETICS); SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

FUNGI; MYXOGASTRIA; SACCHAROMYCES CEREVISIAE;

EID: 0031439601     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002940050293     Document Type: Article

References (55)

1. Attardi G, Schatz G (1988) Biogenesis of mitochondria. Annu Rev Cell Biol 4:289-333
2. Baldacci G, Bernardi G (1982) Replication origins are associated with transcription initiation sequences in the mitochondrial genome of yeast. EMBO J 8:987-994
3. Baldacci G, Chérif-Zahar B, Bernardi G (1984) The initiation of DNA replication in the mitochondrial genome of yeast. EMBO J 3:2115-2120
4. Berman J, Eisenberg S, Tye B-K (1987) An agarose-gel electrophoresis assay for the detection of DNA-binding activities in yeast cell extracts. Methods Enzymol 155:528-537
5. Biswas TK, Edwards JC, Rabinowitz M, Getz GS (1985) Characterization of a yeast mitochondrial promoter by deletion mutagenesis. Proc Natl Acad Sci USA 82:1954-1958
6. Buchman AR, Lue NF, Kornberg RD (1988) Connections between transcriptional activators, silencers and telomeres as revealed by functional analysis of a yeast DNA-binding protein. Mol Cell Biol 8:5086-5099
7. Butow RA, Docherty R, Parikh VS (1988) A path from mitochondria to the yeast nucleus. Phil Trans R Soc Lond 319:127-133
8. Carlson M, Osmond BC, Neigeborn L, Botstein D (1984) A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis in yeast. Genetics 107:19-32
9. Clark-Walker GD (1989) In vivo rearrangement of mitochondrial DNA in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 86:8847-8851
10. 2 and cytochrome c peroxidase are located in the inter-membrane space of yeast mitochondria. J Biol Chem 257:13028-13033
11. Deckert J, Rodriguez Torres AM, Simon JT, Zitomer RS (1995) Mutational analysis of Rox1, a DNA-binding repressor of hypoxic genes in Saccharomyces cerevisiae. Mol Cell Biol 15:6109-6117
12. Diffley JFX, Stillman B (1991) A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. Proc Natl Acad Sci USA 88:7864-7868
13. Diffley JFX, Stillman B (1992) DNA-binding properiies of an HMG1-related protein from yeast mitochondria. J Biol Chem 267:3368-3374
14. Flick JS, Johnston M (1990) Two systems of glucose repression of the GAL1 promoter in Saccharomyces cerevisiae. Mol Cell Biol 10:4757-4769
15. Forsburg SL, Guarente L (1989) Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer. Genes Dev 3:1166-1178
16. Guarente L, Mason T (1983) Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site. Cell 32:1279-1286
17. Hudspeth MES, Shumard DS, Tatti KM, Grossman LI (1980) Rapid purification of yeast mitochondrial DNA in high yield. Biochim Biophys Acta 610:221-228
18. Ito H, Fukuda Y, Murata K, Kimura A (1983) Transformation of intact yeast cells treated with alkali cation. J Bacteriol 153: 163-168
19. Jia Y, Rothermel B, Thornton J, Butow RA (1997) A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signalling pathway from mitochondria to the nucleus. Mol Cell Biol 17:1110-1117
20. Keleher CA, Redd MJ, Schultz J, Carlson M, Johnson AD (1992) Ssn6-Tup1 is a general repressor of transcription in yeast. Cell 68:709-719
21. Lowry CV, Zitomer RS (1988) ROX1 encodes a heme-induced repression factor regulating ANB1 and CYC7 of Saccharomyces cerevisiae. Mol Cell Biol 8:4651-4658
22. Mattoon JR, Lancashire WE, Sanders HK, et al. (1979) Oxygen and catabolite regulation of hemoprotein biosynthesis in yeast. In: Caughey WJ (ed) Biochemical and clinical aspects of oxygen. Academic Press, New York, pp 421-435
23. McNabb DS, Xing Y, Guarente L (1995) Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT binding. Genes Dev 9:47-58
24. Mueller DM, Getz GS (1986) Steady state analysis of mitochondrial RNA after growth of yeast Saccharomyces cerevisiae under catabolite repression and de-repression. J Biol Chem 261: 11816-11822
25. Nehlin JO, Ronne H (1990) Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins. EMBO J 9:2891-2898
26. Nehlin JO, Carlberg M, Ronne H (1991) Control of yeast GAL genes by the MIG1 repressor: a transcriptional cascade in the glucose response. EMBO J 10:3373-3377
27. Niederacher D, Entian K-D (1991) Characterization of HEX2 protein, a negative regulatory element necessary for glucose repression in yeast. Eur J Biochem 200:311-319
28. Olesen JT, Guarente L (1990) The HAP2 subunit of yeast CCAAT transcriptional activator contains adjacent domains for subunit association and DNA recognition: model for the HAP2/3/4 complex. Genes Dev 4:1714-1729
29. Parikh VS, Morgan MM, Scott R, Clements LS, Butow RA (1987) The mitochondrial genotype can influence nuclear gene expression in yeast. Science 235:576-580
30. Polakis ES, Bartley W (1965) Changes in the enzyme activities of Saccharomyces cerevisiae during aerobic growth on different carbon sources. Biochem J 97:284-297
31. Polakis ES, Bartley W, Meek GA (1965) Changes in the activities of respiratory enzymes during the aerobic growth of yeast on different carbon sources. Biochem J 97:298-302
32. Rothermel BA, Shyjan AW, Etheredge JL, Butow RA (1995) Transactivation by Rtg1p, a basic helix-loop-helix protein that functions in communication between mitochondria and the nucleus in yeast. J Biol Chem 270:29476-29482
33. Santangelo GM, Tornow J (1990) Efficient transcription of the glycolytic gene ADH1 and three translational component genes require the GCR1 product, which can act through TUF/GRF/RAP binding sites. Mol Cell Biol 10:859-862
34. Santangelo GM, Tornow J, Moldave K (1986) Cloning of open reading frames and promoters from the Saccharomyces cerevisiae genome: construction of genomic libraries of random small fragments. Gene 46:181-186
35. Santangelo GM, Tornow J, McLaughlin CS, Moldave K (1988) Properties of promoters cloned randomly from the Saccharomyces cerevisiae genome. Mol Cell Biol 8:4217-4224
36. Santangelo GM, Tornow J, McLaughlin CS, Moldave K (1991) Screening a yeast promoter library leads to the isolation of the RP29/L32 and SNR17B/RPL37A divergent promoters and the discovery of a gene encoding L37. Gene 105:137-138
37. Sherman F, Fink GR, Hicks JB (1986) Methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
38. Siemens TV, Nichols DL, Zitomer RS (1980) The effect of mitochondrial functions on the synthesis of yeast cytochrome c. J Bacteriol 142:499-507
39. Skelly PJ, Clark-Walker GD (1990) Conversion at large intergenic regions of mitochondrial DNA in Saccharomyces cerevisiae. Mol Cell Biol 10:1530-1537
40. Skelly PJ, Maleszka R (1989) Isolation of mitochondrial DNA using pulsed-field gel electrophoresis. Nucleic Acids Res 17:7537
41. Southern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98: 503-517
42. Steele DF, Butler CA, Fox TD (1996) Expression of a re-coded nuclear gene inserted into yeast mitochondrial DNA is limited by mRNA-specific translational activation. Proc Natl Acad Sci USA 93:5253-5257
43. Thorsness PE, Fox TD (1990) Escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae. Nature 346:376-379
44. Ticho BS, Getz GS (1988) The characterization of yeast mitochondrial RNA polymerase. J Biol Chem 263:10096-10103
45. Tung K-S, Norbeck L, Nolan SL, Atkinson NS, Hopper AK (1992) SRN1, a yeast gene involved in RNA processing, is identical to HEX2/REG1, a negative regulator in glucose repression. Mol Cell Biol 12:2673-2680
46. Ulery TL, Jang SH, Jaehning JA (1994) Glucose repression of yeast mitochondrial transcription: kinetics of de-repression and role of nuclear genes. Mol Cell Biol 14:1160-1170
47. Weiller G, Schueller CME, Schweyen R (1989) Putative target sites for mobile G+C-rich clusters in yeast mitochondrial DNA: single elements and tandem arrays. Mol Gen Genet 218:272-283
48. Wilcoxen SE, Peterson CR, Winkley CS, Keller MJ, Jaehning JA (1988) Two forms of RPO41-dependent RNA polymerase. J Biol Chem 263:12346-12351
49. Williams FE, Varanasi U, Trumbly RJ (1991) The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex. Mol Cell Biol 11:3307-3316
50. Winkler H, Adam G, Mattes E, Schanz M, Hartig A, Ruis H (1988) Coordinate control of synthesis of mitochondrial and non-mitochondrial hemoproteins: a binding site of the HAP1 (CYP1) protein in the UAS region of the yeast catalase T (CTT) gene. EMBO J 7:1799-1804
51. Zamaroczy M de, Bernardi G (1986) The GC clusters of the mitochondrial genome of yeast and their evolutionary origin. Gene 41:1-22
52. Zamaroczy M de, Marotta R, Faugeron-Fonty G, Goursot R, Mangin M, Baldacci G, Bernardi G (1981) The origins of replication of the yeast mitochondrial genome and the phenomenon of suppressivity. Nature 292:75-78
53. Zamaroczy M de, Faugeron-Fonty G, Baldacci G, Goursot R, Bernardi G (1984) The ori sequences of the mitochondrial genome of a wild-type yeast strain: number, location, orientation and structure. Gene 32:439-457
54. Zinn AR, Pohlman JK, Perlman PS, Butow RA (1988) In vivo double-strand breaks occur at recombinogenic G+C-rich sequences in the yeast mitochondrial genome. Proc Natl Acad Sci USA 85:2686-2690
55. Zitomer RS, Lowry CV (1992) Regulation of gene expression by oxygen in Saccharomyces cerevisiae. Microbiol Rev 56: 1-11