Hydrophobicity versus activity in crosslinked interfacial peptide inhibitors of HIV-1 protease

Tetrahedron Asymmetry

Volumn 8, Issue 23, 1997, Pages 3881-3886

  Shultz, Michael D ^a   Chmielewski, Jean ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; PROTEINASE INHIBITOR;

ARTICLE; DRUG SYNTHESIS; FLUORESCENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHILICITY; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN CROSS LINKING;

EID: 0031438901     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(97)00572-7     Document Type: Article

References (10)

1. Retroviral Proteases, Pearl, L. H., Ed.; McMillan Press, Basingstoke, UK; 1990.
2. Norbeck, D. W.; Kempf, D. J. Ann. Rev. Med. Chem. 1991, 26, 141.
3. Wlodawer, A.; Miller, A.; Jaskolski, M.; Sathyanarayana, B.; Baldwin, E.; Weber, I.; Selk, L.; Clawson, L.; Schneider, J.; Kent, S. Science 1989, 245, 616-621.
4. (a) Schramm, H. J.; Nakashima, H.; Schramm, W.; Wakayama, H.; Yamamoto, N. Biochem. Biophys. Res. Comm. 1991, 179, 847-851.
5. (b) Zhang, Z.; Poorman, R.; Maggiora, L.; Heinrikson, R.; Kezdy, F. J. Biol. Chem. 1991, 266, 15591-15594.
6. (c) Franciskovich, J; Houseman, K.; Mueller, R.; Chmielewski J. Bioorg. Med. Chem. Lett. 1993, 3, 765-768.
7. (d) Schramm, H.; Billich, A.; Jaeger, E.; Rucknagel, K.; Arnold, G.; Schramm, W. Biochem. Biophys. Res. Comm. 1993, 194, 595-600.
8. Zutshi, R.; Franciskovich, J.; Shultz, M.; Schweitzer, Bishop, P.; Wilson, M.; Chmielewski, J. J. Am. Chem. Soc. 1997, 119, 4841-4845.
9. Toth, M. V.; Marshall, G. R. Int. J. Peptide Protein Res. 1990, 36, 544.
10. Waldberger, C. D.; Jonsson, T.; Sauer, R. T. Proc. Natl. Acad. Sci 1996, 93, 2629-2634.