Herbicide-induced experimental variegate porphyria in mice: Tissue porphyrinogen accumulation and response to porphyrogenic drugs

Canadian Journal of Physiology and Pharmacology

Volumn 75, Issue 10-11, 1997, Pages 1181-1187

  Krijt, Jan ^a   Stranska, Pavla ^a   Maruna, Pavel ^a   Vokurka, Martin ^a   Sanitrak, Jaroslav ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Heme; Oxadiazon; Oxyfluorfen; Protoporphyrinogen

Indexed keywords

AMINOLEVULINIC ACID; CYTOCHROME P450; HERBICIDE; OXADIAZON; OXYFLUORFEN; PHENOBARBITAL; PHENYTOIN; PORPHOBILINOGEN; PORPHYRINOGEN; PROTOPORPHYRINOGEN OXIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; MOUSE; NONHUMAN; PERIPHERAL NEUROPATHY; PORPHYRIA VARIEGATA; PORPHYRIN METABOLISM; PRIORITY JOURNAL;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; HERBICIDES; KIDNEY; LIVER; MALE; MICE; MICE, INBRED STRAINS; OXADIAZOLES; PHENYL ETHERS; PORPHOBILINOGEN; PORPHYRIAS; PORPHYRINOGENS; PORPHYRINS;

EID: 0031438887     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/cjpp-75-10-11-1181     Document Type: Article

References (32)

1. Aitio, A. 1978. A simple and sensitive assay of 7-ethoxycoumarin deethylation. Anal. Biochem. 85: 488-491.
2. Aizawa, T., Hiramatsu, K., Ohtsuka, H., Niwa, A., Yukimura, Y., Yamada, T., Kiyosawa, K., Furuta, S., Ogata, H., and Miyamoto, H. 1987. Defective hepatic anion transport in variegate porphyria. Am. J. Gastroenterol. 82: 1180-1185.
3. Asbury, A.K., Sidman, R.L., and Wolf, M.K. 1966. Drug-induced porphyrin accumulation in the nervous system. Neurology, 16: 320.
4. Badawy, A.A.B., Welch, N., and Morgan, C.J. 1981. Tryptophan pyrrolase in heme regulation. Biochem. J. 198: 309-314.
5. Brenner, D.A., and Bloomer, J.R. 1980. The enzymatic defect in variegate porphyria: studies with human cultured skin fibroblasts. N. Engl. J. Med. 302: 765-769.
6. Camadro, J.M., Matringe, M., Scalla, R., and Labbe, P. 1993. Fluorometric assay of protoporphyrinogen oxidase in chloroplasts and in plant, yeast and mammalian mitochondria. In Target assays for modern herbicides and related phytotoxic compounds. Edited hy P. Böger and G. Sandmann. CRC Press/Lewis Publishers, Boca Raton, Fla. pp. 29-34.
7. Day, R.S., Blekkenhorst, G.H., and Eales, L. 1980. Hepatic porphyrins in variegate porphyria. N. Engl. J. Med. 303: 1368-1369.
8. De Matteis, F., and Marks, G.S. 1996. Cytochrome P450 and its interaction with the heme biosynthetic pathway. Can. J. Physiol. Pharmacol. 74: 1-8.
9. De Matteis, F., and Stonard, M. 1977. Experimental porphyrias as models for human hepatic porphyrias. Semin. Hematol. 14: 187-192.
10. Deybach, J.Ch., de Verneuil, H., and Nordmann, Y. 1981. The inherited enzymatic defect in porphyria variegata. Hum. Genet. 58: 425-428.
11. Gray, Ch.H. 1950. Acute porphyria. Arch. Int. Med. 85: 459-470.
12. Jacobs, J.M., and Jacobs, N.J. 1993. Porphyrin accumulation and export by isolated barley (Hordeum vulgare) plastids. Plant Physiol. 101: 1181-1187.
13. Kappas, A., Sassa, S., Galbraith, R.A., and Nordmann, Y. 1995. The porphyrias. In The metabolic and molecular basis of inherited disease. Edited by C.R. Scriver, A.L. Beandet, W.S. Sly, and D. Valle, McGraw-Hill, New York. pp. 2103-2159.
14. Krijt, J., Pleskot, R., Sanitrak, J., and Janousek, V. 1992. Experimental hepatic porphyria induced by oxadiazon in male mice and rats. Pestic. Biochem. Physiol. 42: 180-187.
15. Li, F., Lim, C.K., Simpson, K.J., and Peters, T.J. 1989. Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in human liver biopsies with special reference to alcoholic liver disease. J. Hepatol. 8: 86-93.
16. Lindberg, R.L.P., Porcher, C., Grandchamp, B., Ledermann, B., Bürki, K., Brandner, S., Aguzzi, A., and Meyer, U.A. 1996. Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria. Nat. Genet. 12: 195-199.
17. Long, C., Smyth, S.J., Woolf, J., Murphy, G.M., Finlay, A.Y., Newcombe, R.G., and Elder, G.H. 1993. Detection of latent variegate porphyria by fluorescence emission spectroscopy of plasma. Br. J. Dermatol. 129: 9-13.
18. Marks, G.S. 1985. Exposure to toxic agents: the heme biosynthetic pathway and hemoproteins as indicator. CRC Crit. Rev. Toxicol. 15: 151-179.
19. Martasek, P., Kordac, V., and Jirsa, M. 1983. Variegate porphyria and porphyria cutanea tarda. Arch. Dermatol. 119: 537-538.
20. Matringe, M., Camadro, J.M., Labbe, P., and Scalla, R. 1989. Protoporphyrinogen oxidase inhibition by three peroxidizing herbicides: oxadiazon, LS-82-556 and M&B 39279. FEBS Lett. 245: 35-38.
21. Meissner, P., Adams, P., and Kirsch, R. 1993. Allosteric inhibition of human lymphoblast and purified porphobilinogen deaminase by protoporphyrinogen and coproporphyrinogen. A possible mechanism for the acute attack of variegate porphyria. J. Clin. Invest. 91: 1436-1444.
22. Moore, M.R., McColl, K.E.L., Rimington, C., and Goldberg, A. 1987. Pathogenesis of the neuropathy of acute porphyrias. In Disorders of porphyrin metabolism. Plenum Publishing Corporation, New York. pp. 119-137.
23. Poh-Fitzpatrick, M.B. 1980. A plasma porphyrin fluorescence marker for variegate porphyria. Arch. Dermatol. 116: 543-547.
24. Puy, H., Deybach, J.Ch., Bogdan, A., Callebert, J., Baumgartner, M., Voisin, P., Nordmann, Y., and Touitou, Y. 1996. Increased 5-aminolevulinic acid and decreased melatonin production. A common event in acute porphyria studies in the rat. J. Clin. Invest. 97: 104-110.
25. Riopelle, R.J., and Kennedy, J.C. 1982. Some aspects of porphyrin neurotoxicity in vitro. Can. J. Physiol. Pharmacol. 60: 707-714.
26. Rutten, A.A.J.J.L., Falke, H.E., Catsburg, J.F., Topp, R., Blaauboer, B.J., Holsteijn, I., Doom, L., and van Leeuwen, R. 1987. Interlaboratory comparison of total cytochrome P-450 and protein determinations in rat liver microsomes. Arch. Toxicol. 61: 27-33.
27. Rutten, A.A.J.J.L., Falke, H.E., Catsburg, J.F., Wortelboer, H.M., Blaauboer, B.J., Doom, L., van Leeuwen, F.X.R., Theelen, R., and Rietjens, I.M.C.M. 1992. Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufm O-dealkylation determinations: standardization of assay conditions. Arch. Toxicol. 66: 237-244.
28. Sanitrak, J., Krijt, J., Coupek, J., Janousek, V., and Magnus, I.A. 1987. Determination of porphyrins in tissue: preadsorption followed by high-performance liquid chromatography. J. Chromatogr. 415: 129-133.
29. Siersema, P.D., De Rooij, F.W.M., Edixhoven-Bosdijk, A., and Wilson, J.H.P. 1990. Erythrocyte porphobilinogen deaminase activity in porphyria cutanea tarda. Clin. Chem. 36: 1779-1783.
30. Sinclair, P.R., Gorman, N., Walton, H.S., Sinclair, J.F., Jacobs, J.M., and Jacobs, N.J. 1994. Protoporphyrinogen accumulation in cultured hepatocytes treated with the diphenyl ether herbicide, acifluorfen. Cell. Mol. Biol. 40: 891-897.
31. Tokola, O., Mustajoki, P., and Himberg, J.J. 1988. Haem arginate improves hepatic oxidative metabolism in variegate porphyria. Br. J. Clin. Pharmacol. 26: 753-757.
32. Von Burg, R. 1994. Toxicology update - oxadiazon. J. Appl. Toxicol. 14: 69-71.