An enantioselective synthetic route to atractyligenin using the oxazaborolidine-catalyzed reduction of β-silyl- or β-stannyl-substituted α,β-enones as a key step

Journal of the American Chemical Society

Volumn 119, Issue 49, 1997, Pages 11769-11776

  Corey, E J ^a   Guzman Perez, Angel ^a   Lazerwith, Scott E ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATRACTYLIGENIN; ATRACTYLOSIDE; ATRACTYLOSIDE DERIVATIVE; POLYCYCLIC HYDROCARBON; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPTICAL ROTATION; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0031438010     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja973034o     Document Type: Article

References (4)

1. Atractyloside: Chemistry, Biochemistry and Toxicology; Santi, R., Luciani, S., Eds.; Piccin Medical Books: Padova, Italy, 1978.
2. The Merck Index, 12th ed.; Budavari, S., Ed.; Merck: Whitehouse Station, NJ, 1996; p 902.
3. Klingenberg, M. Trends Biochem. Sci. 1979, 4, 249.
4. For the structural determination of 1 and 2, see: (a) Piozzi, F.; Quilico, A.; Mondelli, R.; Ajello, T.; Sprio, V.; Malera, A. Tetrahedron 1966, Suppl 8, Part II, 515.