Molecular modelling and biological evaluation of a series of hydroxylated benzylideneanilines and benzylamines designed as tyrosine kinase inhibitors

Anti-Cancer Drug Design

Volumn 12, Issue 8, 1997, Pages 635-647

  Solomons, Kevin R H ^a   Lieberman, Harvey F ^a   Groundwater, Paul W ^a,b   Hibbs, David E ^a   Hursthouse, Michael B ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF SUNDERLAND   (United Kingdom)

Author keywords

Biological activity; Hydroxylated benzylamines; Hydroxylated benzylideneanilines; Inhibitors; Molecular modelling; Protein tyrosine kinases; Synthesis

Indexed keywords

ANILINE DERIVATIVE; BENZYLIDENE DERIVATIVE; DRUG CARRIER; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANILINE COMPOUNDS; BENZYLAMINES; BENZYLIDENE COMPOUNDS; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; MODELS, CHEMICAL; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0031437923     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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