Effects of topical antiandrogen and 5-alpha-reductase inhibitors on sebaceous glands in male fuzzy rats

Skin Pharmacology and Physiology

Volumn 10, Issue 5-6, 1997, Pages 288-297

  Ye, Fangfang ^a   Imamura, Koji ^a   Imanishi, Noriko ^a   Linda, Rhodes ^b   Hideo, Uno ^c  

^a UNIVERSITY OF WISCONSIN   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Finasteride; Fuzzy rat; RU58841; Sebaceous gland

Indexed keywords

4 [3 (4 HYDROXYBUTYL) 4,4 DIMETHYL 2,5 DIOXO 1 IMIDAZOLIDINYL] 2 TRIFLUOROMETHYLBENZONITRILE; 4,7BETA DIMETHYL 4 AZACHOLESTAN 3 ONE; ANTIANDROGEN; BROXURIDINE; FINASTERIDE; STEROID 5ALPHA REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ACNE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; IMMUNOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTATE; RAT; SEBACEOUS GLAND; SEBACEOUS GLAND DISEASE; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANDROGEN ANTAGONISTS; ANIMALS; BROMODEOXYURIDINE; DERMATITIS, SEBORRHEIC; DIHYDROTESTOSTERONE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; MALE; ORGAN SIZE; RATS; RATS, MUTANT STRAINS; SEBACEOUS GLANDS; TESTOSTERONE; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0031437865     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000211517     Document Type: Article

References (32)

1. Takayasu S, Wakimoto H, Itami S, Sano S: Activity of testosterone 5α-reductase in various tissues of human skin. J Invest Dermatol 1980: 74:187-191.
2. 5-3β-Hydroxvsteroid dehydrogenase activity in sebaceous glands of scalp in male-pattern baldness. J Invest Dermatol 1988:91: 101-105.
3. Itami S, Kurata S, Sonada S, Takayasu S: Characterization of 5α-reductase in cultured human dermal papilla cells from beard and occipital scalp hair. J Invest Dermatol 1991;96:57-60.
4. Akamatsu H, Zouboulis CC, Orfanos CE: Control of human sebocyte proliferation in vitro by testosterone and 5-alpha-dihvdrotestosterone is dependent on the localization of the sebaceous glands. J Invest Dermatol 1992:99:509-511.
5. Impcrato-McGinley J, Gautier T, Cai LQ, Yec B. Epstein J, Pochi P: The androgen control of sebum production - Studies of subjects with dihydrotestostcrone deficiency and complete androgen insensitivity. J Clin Endocrinol Metab 1993:76: 524-528.
6. Andersson S, Bishop RW, Russell DW: Expression cloning and regulation of steroid 5a-reductasc and enzyme essential for male sexual differentiation. J Biol Chem 1989:264: 16249-16255.
7. Uno H: Biology of hair growth: in Speroff E (ed): Seminars in Reproductive Endocrinology: Andrology in Women. New York. Thieme-Stratton, 1986, vol 4. pp 131-141.
8. Rittmaster RS, Uno H, Povar ML, Mellin TN, Loriaux DL: The effects of 4-MA, a 5α-reductase inhibitor and anti-androgen, on the development of baldness in the slumptail macaque. J Clin Endocrinol Metab 1987:65:188-193.
9. Rhodes L, Harper J, Uno H, Gaito G, Audette-Arruda J, Kurata S, Berman C, Primka R, Pikounis B: The effect of finasteride (Proscar) on hair growth, hair cycle stage, and serum testosterone and dihydrotestosterone in adult male and female stump-tail macaques (Macaco arcloides). J Clin Endocrinol Metab 1994;78: 991-996.
10. Kaufman KD: Clinical studies on the effects of oral finasteride, a type II 5u-reductase inhibitor, on scalp hair in men with male pattern baldness; in Van Neste DJJ. Randall VA (eds): Hair Research for the Next Millenium. Amsterdam. Elsevier, 1996. pp 363-365.
11. Rhodes L, Primka R, Berman C, Gato G. Audette-Arruda J, Pikounis B, Matuszcwska B. Harper J: Effects of 1 year treatment with oral MK386, an inhibitor of type I 5a-reductasc in the stumptailcd macaque (Macaca arcloides). J Invest Dermatol 1995:104:658.
12. Thigpen AE, Silver R, Guilcyardo J, Casey ML, McConnell JD, Russell DW: Tissue distribution and ontogeny of steroid 5α-reductase isozyme expression. J Clin Invest 1993:92: 903-910.
13. Normington K, Russell DW: Tissue distribution and kinetic characteristics of rat steroid 5a-reductase isozymes. J Biol Chem 1992:267: 19548-19554.
14. Prahalada SR, Peter CP, Keenan KP, Hertzog PR, Gordon LR, Peter CP, Soper KA, VanZwieten MJ, Bokelman DK: Qualitative and quantitative evaluation of prostatic histo-morphology in rats following chronic treatment with finasteride, a 5α-reductase inhibitor. Urology 1994:43:680-685.
15. Rittmaster RS, Manning AP, Wright AS, Thomas LN, Whitefield S, Norman RW, Lazier CB. Rowden G: Evidence for atrophy and apoptosis in the ventral prostate of rats given the 5a-reductase inhibitor finasteride. Endocrinology 1995:136: 741-748.
16. Andersson A, Russell DW: Structural and biochemical properties of cloned and expressed human and rat steroid 5α-reductases. Proc Natl Acad Sci USA 1990;87:3640-3644.
17. Ye F, Ramiraz S, Obana N, Douglas S, Rhodes L, Uno H: Effects of human type I and II 5α-reductase inhibitors on the hyperplastic sebaceous glands in male fuzzy rats. J Invest Dermatol 1996:106:948.
18. Battmann T, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D: RU58841. a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgcnctic alopecia and hirsutism. J Stercid Biochcm Mol Biol 1994:48:55-60.
19. Ferguson FG, Irving GW III, Stedham MA: Three variations of hairlessness association with albinism in the laboratory rat. Lab Anirn Sci 1979;29:459-465.
20. Plewig G, Kligman AM: Aene: Morphogenesis and Treatment. Berlin, Springer. 1975.
21. Uno H, Fors TD, Packard SM, Bazzano GS, Kligman AM: Androgen-dependent activity of the sebaceous gland and the effect of topical tretinoin in fuzzy rats. J Invest Dermatol 1990:94:587.
22. Grino PB, Griffin JH, Wilson JD: Testosterone at high concentrations interacts with the human androgen receptor similarly to dihvdrotcstos-tcrone. Endocrinology 1990:126: 1165-1172.
23. Uno H, Obana N, Cappas A, Bonfils A, Battmann T, Philibert D: Stimulation of follicular regrowth by androgen receptor blocker (RU58841) in macaque androgcnetic alopecia; in Van Neste DJJ. Randall VA (eds): Hair Research for the Next Millenium. Amsterdam. Elsevier. 1996. pp 349-353.
24. Obana N, Uno H: Dermal papilla cells in macaque alopecia trigger a testosterone-dependent inhibition of follicular cell proliferation; in Van Neste DJJ. Randall VA (eds): Hair Research for the Next Millenium. Amsterdam, Elsevier. 1996. pp 307-310.
25. Imperato-McGinley J, Guerrero L, Gautier T, Peterson RE: Steroid 5 alpha-reductase deficiency in man: An inherited form of male pseudohermaphroditism. Science 1974: 1986:1213-1215.
26. Imperato-McGinley J, Gautier T, Cai Li-Qun, Yce B, Epstein J, Pochi P: The androgen control of sehum production: Studies of subjects with dihydrotcstosterone deficiency and complete androgen insensitivity. J Clin Endocrinol Metab 1993:76: 524-528.
27. Takayasu S, Wakimoto H, Itami S, Sano S: Activity of 5α-reductase in various tissues of human skin. J Invest Dermatol 1980;74:187-191.
28. Andersson S, Berman DM, Jenkins EP. Russell DW: Deletion of steroid 5a-reductase 2 gene in male pseudohermaphroditism. Nature (Lond) 1991:354:159-161.
29. Schwartz JI, Van Hecken A, De-Schepper PJ, DeLepclcire I, Lasseter KC, Shamlen EC. Winchcll GA, Constanzer ML, Chavez CM, Wang DZ, Ebel DL, Justice SJ, Gertz BJ: Effect of MK386, a novel inhibitor of type I 5a-reductasc. alone and in combination with finasteride, on serum DHT concentrations in men. J Clin Endocrinol Metab 1996:81: 2942-2927.
30. Moore RJ, Wilson JD: Steroid 5α-reductase in cultured human fibroblasts: Biochemical and genetic evidence for two distinct enzyme activities. J Biol Chcm 1976:251:5895-5900.
31. Russell DW, Wiley EL, Whiting DA: Expression of steroid 5α-reduc-tase I and 11 in scalp skin in normal controls and in androgenetic alopecia: in Van Neste DJJ. Randall VA (eds): Hair Research for the Next Millenium. Amsterdam. Elsevier. 1996. pp 339-340.
32. Bayne EK, Flanagan J, Azzolina B, Einstein M, Mumford R, Ayala J, Chang B, Thiboutot D, Singer H, Harris G: lmmunolocalization of type 2 5α-reductasc in human hair follicles. J Invest Dermatol 1997: 108:651.