2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 12, 1997, Pages 2129-2132

  Micheli, Fabrizio ^a   Cugola, Alfredo ^a   Donati, Daniele ^a   Missio, Andrea ^a   Pecunioso, Angelo ^a   Reggiani, Angelo ^a   Tarzia, Giorgio ^b  

^a GLAXOSMITHKLINE   (United States)

^b UNIVERSITY OF URBINO   (Italy)

Author keywords

Glycine; MCAo; NMDA; Pyrido 2,3 b pyrazine; Stroke

Indexed keywords

2,3 DIHYDRO 6,7 DICHLORO PYRIDO[2,3 B]PYRAZINE 8 OXIDE; GLYCINE RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CONVULSION; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCLUSIVE CEREBROVASCULAR DISEASE; RAT;

ANIMALS; AVOIDANCE LEARNING; BINDING SITES; CYCLIC N-OXIDES; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; KYNURENIC ACID; MICE; MOTOR ACTIVITY; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; PYRAZINES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SEIZURES; STEREOTYPED BEHAVIOR; STRYCHNINE;

EID: 0031437733     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)00156-9     Document Type: Article

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