Alzheimer disease: From molecular biology to therapy

Advances in Experimental Medicine and Biology

Volumn 429, Issue , 1997, Pages 235-245

  Giacobini, Ezio ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BETHANECHOL; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINESTERASE INHIBITOR; PHORBOL MYRISTATE; PHYSOSTIGMINE; TACRINE;

ALZHEIMER DISEASE; ARTICLE; CHOLINERGIC SYSTEM; DRUG MECHANISM; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTEIN PROCESSING;

EID: 0031437384     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4757-9551-6_17     Document Type: Article

References (53)

1. Allain, H. Maruelle, L., Beneton, C., Rouault, G., and Belliard, S. (1996). Acute episodes of high blood pressure with tacrine. Presse Medicale 25:30 pp 1388-1389.
2. Amberia, K., Nordberg, A., Viitanen, M., and Winblad, B. (1993). Long-term treatment with tacrine (THA) in Alzheimer's disease - evaluation of neuropsychological data. Acta Neurologica Scandinavica Supplement 149 pp 55-57.
3. Anderson, J.P., Refolo, L.M., Wallace, W., Mehta, P., Krishnamurthi, M., Gotlib, J., Bierer, L., Haroutunian, V., Perl, D. and Robakis, N.K. (1989). Differential brain expression of the Alzheimer's amyloid precursor protein. EMBO Journal 8: pp 3627-3632.
4. Becker, R., Moriearty, P., and Unni, L. (1991). The second generation of cholinesterase inhibitors: Clinical and pharmacological effects In Cholinergic basis for Alzheimer Therapy pp 263-296. Edited by Becker, R. and Giacobini, E.. Boston: Birkhauser.
5. Beeson, J.G., Shelton, E.R., Chan, H.W. and Gage, F.H. (1994). Differential distribution of amyloid protein precursor immunoreactivity in the rat brain studied by using five different antibodies. Journal of Comparative Neurology 342: pp 78-96.
6. Biyah, K., Molimard, M, Naline, E., Bazelly, B., and Advenier, C. (1996). Indirect muscarinic receptor activation by pentamidine on airway smooth muscle British Journal of Pharmacology 119:6 pp 1131-1136.
7. Buxbaum, J.D., Oishi, M., Chen, H.I., Pinkas-Kramarski, R., Jaffe, E.A., Gandy, S.E. and Greengard, P. (1992). Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer βA4 amyloid protein precursor. Proceedings of National Academy of Science, USA 89: pp 10075-10078.
8. Buxbaum, J.D. (1995). Post-translational control of the amyloid b-protein precursor processing. In Pathobiology of Alzheimer's Disease, Academic Press Limited, pp 98-114.
9. Checler, F. (1995). Processing of the b-amyloid precursor protein and its regulation in Alzheimer's disease. Journal of Neurochemistry 65:4 pp 1431-1444.
10. Chong, Y.H. and Suh, Y.H. (1996). Amyloidogenic processing of Alzheimer's amyloid precursor protein in vitro and its modulation by metal ions and tacrine. Life Science 59/7 pp 545-557.
11. Eagger, S., Richards, M., and Levy, R. (1994). Long-term effects of tacrine in Alzheimer's disease: an open study. International Journal of Geriatric Psychiatry 9 pp 643-647.
12. Feldman, S., and Karalliedde, L. (1996). Drug interactions with neuromuscular blockers. Drug-Safety 15:4 pp 261-273.
13. Giacobini, E. (1987). Models and strategies of cholinomimetic therapy of Alzheimer disease. In Cellular and mo-lecular basis of cholinergic function, pp 882-901. Edited by Dowdall , M.J. and Hawthorne, J.N. England: Ellis Horwood.
14. Giacobini, E. (1996a). Closer to the truth about ApoE-4. Alzheimer Insights 2/2 pp 1-4.
15. Giacobini, E. (1996b). Cholinesterase inhibitors do more than inhibit cholinesterase. In Alzheimer Disease: From Molecular Biology to Therapy (pp 187-204). Edited by Becker, R. and Giacobini, E.. Boston: Birkhäuser.
16. Giacobini, E., Becker, R., Elble, T., Mattio, M., McIlhany, M. and Scarsella, G. (1987). Brain acetylcholine - A view from the cerebrospinal fluid. In Neurobiology of Acetylcholine (pp 85-101). Edited by Dun, N., New York: Plenum Press.
17. Giacobini, E. and Cuadra, G. (1994). Second and third generation cholinesterase inhibitors: From preclinical studies to clinical efficacy. In: Alzheimer Disease: Therapeutic Strategies (pp. 155-171). Edited by Giacobini, E. and Becker, R., Boston: Birkhauser.
18. Giacobini, E., Mori, F., Buznikov, A. and Becker, R. (1995). Cholinesterase inhibitors alter APP secretion and APP mRNA in rat cerebral cortex. Society of Neuroscience Abstracts 21 pp 988.
19. Giacobini, E., Zhu, X.D., Williams, E., and Sherman, K.A. (1996). The effect of the selective reversible acethylcholinesterase inhibitor E2020 on extracellular acetylcholine and biogenic amines levels in rat cortex. Neuropharmacology 35 (2) pp 205-211.
20. Gracon, S., Smith, F. and Hoover, T. (1996). Long-term tacrine treatment: Effect on nursing home placement and mortality. In Alzheimer Disease: From Molecular Biology to Therapy (pp 205-209). Edited by Becker, R. and Giacobini, E.. Boston: Birkhauser.
21. Hallak, M. and Giacobini, E. (1986). Relation of brain regional physostigmine concentrations to cholinesterase activity, and acetylcholine and choline levels in rat. Neurochemistry Research 11 pp 1037-1048.
22. Haroutunian, V., Greig, N., Pei, X.F., Utsuki, L., Acevedo, L.D., Gluck, R., Davis, K.L. and Wallace, D. (1996). Pharmacological modulation of Alzheimer's b-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Society for Neuroscience 22 461.7 pp 1169.
23. Haroutunian, V., Greig, N.H., Gluck, R., Fiber, E., Davis, K.L. and Wallace, W.C. (1995). Selective attenuation of lesion-induced increases in secreted b-APP by acetylcholinesterase inhibitors. Society for Neuroscience 21 208.1 pp 5.
24. Hoshi, M, Takashima, A., Murayama, M., Yasutake, K., Yoshida, N., Ishiguro, K., Hoshino, T. and Imahori K. (1997). Nontoxic amyloid beta peptide(1-42) suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer's disease. Journal of Biological Chemistry 272/4 pp 2038-2041.
25. Imbimbo B.P., Perini, M., Verdelli, G., and Troetel ,W.M. (1997). Two year treatment of Alzheimers's disease with eptastigmine. International Congress of Neurology (Buenos Aires)Abstracts.
26. Kang, J., Lemaire, H.G., Unterbeck, A., Salbaum, J.M., Master, C.L., Grzeschil, K.H., Multaup, G., Beyreuther, K. and Muller-Hill, B. (1987). The precursor of Alzheimer disease amyloid A4 protein resembles a cell-surface receptor. Nature 325 pp 733-736.
27. Knopman, D., Schneider, L., Davis, K., Talwalker, S., Smith, F., Hoover, T. and Gracon, S. (1996). Long-term tacrine treatment. Neurology 47 pp 166-177.
28. Lahiri, D.K., Lewis, S. and Farlow, M.R. (1994). Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines. Journal of Neuroscience Research 37 pp 777-787.
29. Lebert, F., Hasenbroekx, C., Pasquier, F., and Petit , H. (1996). Convulsive effects of tacrine. Lancet 347 pp 1339-1340.
30. Maany, I. (1996). Adverse interaction of tacrine and haloperidol. Americann Journal of Psychiatry 153:11 pp1504.
31. Mattio, T., McIlhany, M., Giacobini, E. and Hallak, M. (1986). The effects of Physostigmine on acetylcholinesterase activity of CSF, plasma and brain. A comparison of intravenous and intraventricular administration in beagle dogs. Neuropharmacology 25 pp 1167-1177.
32. McSwain, ML., and Forman LM. (1995). Severe parkinsonian symptom development on combination treatment with tacrine and haloperidol (letter). Journal of Clinical Psychopharmacology 15 pp:284.
33. Minthon, L, Nilsson, K., Edvinsson, L., Wendt, P.E. and Gustafson, L. (1995). Long-term effects of tacrine on regional cerebral blood flow changes in Alzheimer's Disease. Dementia 6 pp 245-251.
34. Mori, F., Cuadra, G. and Giacobini, E. (1995b). Metrifonate effects on acetylcholine and biogenic amines in rat cortex. Neurochemistry Research 20 (9) pp 1081-1088.
35. Mori, F., Lai, C.C., Fusi, F. and Giacobini, E. (1995a). Cholinesterase inhibitors increase secretion of APPs in rat brain cortex. Neuro Report 6 (4) pp 633-636.
36. Nitsch, R.M., Farber, S.A., Growdon, J.H. and Wurtman, R.J. (1993). Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices. Proceeding of National Academy of Science, USA, 90 pp 191-193.
37. Nitsch, R.M. and Growdon, J.H. (1994). Role of neurotransmission in the regulation of amyloid beta-protein precursor processing. Biochemical Pharmacology 47 (8): 1275.
38. Nordberg, A. (1993). Clinical studies in Alzheimer patients with positron emission tomography. Elsevier Science Publishers, Behavioural Brain Research 57 pp 215-224.
39. Nordberg, A. (1995). Long term treatment effects on progression of Alzheimer's disease as determined by functional brain studies. In Research Advances in Alzheimer's disease and Related Disorders (pp 293-298). Edited by Ikbal, K., Mortimer, J.A., Winblad, B., Wiesniewski, H.M.. Chichester: John & Sons.
40. Poirier, J., Delisle, M.C., Quirion, R., Aubert, I., Farlow, M., Lahiri, D., Hui, S., Bertrand, P., Nalbantoglu, J., Gilfix, B.M. and Gauthier, S. (1995). Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease. Proceeding of National Academy of Science 92 pp 12260-1226.
41. Paddle, B. and Dowling, M. (1996). Blockade of nicotinic responses by anticholinesterases. General Pharmacology 27:5 pp 861-872.
42. Roses, A. (1995). Perspective on the metabolism of apolipoprotein E and the Alzheimer disease. Experimental Neurology 132 pp 149-156.
43. Sandbrink, R., Hartmann, T., Masters, C.L. and Beyreuther, K. (1996). Genes contribution to Alzheimer's disease. Molecular Psychiatry 1 pp 27-40.
44. Soininen, H., Kosunen, O., Helisalmi, S., Mannermaa, A., Paljärvi, L., Talasniemi, S., Ryynänen, M. and Riekkinen, P., Sr. (1995). A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein e4 allele. Neuroscience Letters 187 pp 79-82.
45. Soininen, H., and Riekkinen, J. Sr (1996). Apolipoprotein E, memory and Alzheimer's disease. Trends in Neursoscience 19 pp 224-228.
46. Solomon, P., Knapp, M., Gracon, S., Groccia , M. and Pendlebury, W. (1996). Long-term tacrine treatment in patients with Alzheimer's disease. Lancet 348 pp 275-276.
47. Van Broeckhoven, C. (1995). Presenilins and Alzheimer disease. Nature Genetics 11 pp 230-232.
48. 2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science 271 pp 521-525.
49. Wilcock, G., Scott, M. and Pearsall, T. (1994). Long-term use of tacrine. Lancet 343 pp 294.
50. Yankner, B (1996). New clues to Alzheimer's disease: Unraveling the roles of amyloid and tau. Nature Medicine 2.8 pp 850-852.
51. Zaborsky L. and W.E. Cullinan, (1996). Direct cathecholaminergic-cholinergic interactions in the basal forebrain.I. Dopamine-beta-hydroxylase input to cholinergic neurons. Journal of Comparative Neurology 374 pp 5345-554.
52. Zhu, X.D., Giacobini, E. and Hornsperger, J.M. (1995). Effect of MDL 73,745 on acetylcholine and biogenic amine levels in rat cortex. European Journal of Pharmacology 276 pp 93-99.
53. Zhu, X.D., Cuadra, G., Brufani, M., Maggi, T., Pagella, P.G., Williams, E. and Giacobini, E. (1996). Effects of MF268, a new cholinesterase inhibitor, on acetylcholine and biogenic amines in rat cortex. Journal of Neuroscience Research 43 pp 120-126.