Reproductive and developmental toxicity studies of taltirelin hydrate (4) - Perinatal and postnatal study in rats by oral administration

Journal of Toxicological Sciences

Volumn 22, Issue SUPPL. 2, 1997, Pages 405-417

  Imahie, Hiroshi ^a   Koguchi, Akane ^a   Kobayashi, Takashi ^a   Asano, Yuzo ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Oral administration; Perinatal and postnatal study; Rat; Taltirelin hydrate; TRH analogue

Indexed keywords

TALTIRELIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DEVELOPMENTAL DISORDER; DOSE RESPONSE; DRUG EFFECT; GROWTH RETARDATION; INFERTILITY; NONHUMAN; ORAL DRUG ADMINISTRATION; POSTNATAL GROWTH; RAT; TOXICITY TESTING;

EID: 0031436094     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.22.supplementii_405     Document Type: Article

References (10)

1. Asano,Y. (1986): Characteristics of open field behavior of Wistar and Sprague-Dawley rats. Exp. Anim., 35:505-508.
2. Carole, A.K. and Trammell, C. (1981): A rapid procedure for routine double stainning of cartilage and bone in fetal and adult animals. Stain Technology, 56:5.
3. Dunham, N.W. and Miya, T.S. (1957): A note on a simple apparatus for detecting neurological deficits in rats and mice. J. Am. Pharm. Ass., 46:208-209.
4. Martin, W.R., Wikler, A., Eades, G.G., and Pescor, F.T. (1963):Tolerance to and physical dependence on morphine in rats,Psychopharmacologia., 4, 247.
5. (1995) MONTIRELIN HYDRATE (NS-3) Toxicol. Sci., 20, Suppl. II, 309-323.
6. Nishida, A., Asano, Y. and Okaniwa, A. (1992): Postnatal behavioral development in methylazoxymethanol-induced microcephalic rats. Exp. Anim., 41:413-419.
7. Yamamura, M., Kinoshita, K., and Nakagawa, H., Tanaka, T., Maeda, K., Ishida, R. (1990): Pharmacological study of TA-0910, a new thyrotropin-releasing hormone (TRH)analog, (I): effects on the central nervous system by oral administration. Japan. J. Pharmacol., 53, 451-461.