Antagonism of muscarinic receptors in the rabbit iris-ciliary body by 8-OH-DPAT and other 5-HT(1A) receptor agonists

Journal of Neural Transmission

Volumn 104, Issue 10, 1997, Pages 1015-1025

  Chidlow, G ^a   Osborne, N N ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

5 HT(1A); Carbachol; Iris ciliary body; Muscarinic receptor; Phosphoinositide; Rabbit; Receptor

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; CARBACHOL; INOSITOL PHOSPHATE; MUSCARINIC RECEPTOR; PHOSPHATIDYLINOSITIDE; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR;

ANIMAL TISSUE; BINDING AFFINITY; BINDING SITE; CILIARY BODY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; IRIS; NONHUMAN; PRIORITY JOURNAL; RABBIT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; CILIARY BODY; IRIS; KINETICS; MEMBRANES; MUSCARINIC ANTAGONISTS; PHOSPHATIDYLINOSITOLS; RABBITS; RECEPTORS, MUSCARINIC; SEROTONIN AGONISTS;

EID: 0031434914     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01273315     Document Type: Conference Paper

References (36)

1. Abdel Latif AA (1989) Calcium-mobilizing receptors, polyphosphoinositides, generation of second messengers and contraction in the mammalian iris smooth muscle: historical perspectives and current status. Life Sci 45: 757-786
2. Arunlakshana O, Schild HO (1959) Some quantitative uses of drug antagonists. Br J Pharmacol 14: 48-58
3. Barnett NL, Osborne NN (1993) The effect of serotonin on the rabbit isolated iris sphincter muscle. Curr Eye Res 12: 665-673
4. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
5. Chidlow G, De Santis LM, Sharif NA, Osborne NN (1995) Characteristics of [3H]5-hydroxytryptamine binding to iris-ciliary body tissue of the rabbit. Invest Ophthalmol Vis Sci 36: 2238-2245
6. 1A receptor agonists inhibit carbachol-induced stimulation of phosphoinositide turnover in the rat hippocampus. Eur J Pharmacol 149: 149-153
7. 1A receptors and carbachol-stimulated phosphoinositide turnover in the rat hippocampus. J Neurochem 56: 1276-1285
8. 1A receptor agonists improve the performance of normal and scopolamine-impaired rats in an operant delayed matching to position task. Psychopharmacology Berl 116: 135-142
9. Consolo S, Ladinsky H, Forloni GL, Tirelli AS, Garattini S (1980) Comparison of the effects of the stereoisomers of fenfluramine on the acetylcholine content of rat striatum, hippocampus and nucleus accumbens. J Pharm Pharmacol 32: 201-203
10. Crist J, Surprenant A (1987) Evidence that 8-hydroxy-2-(n-dipropylamino)tetralin (8-OH-DPAT) is a selective alpha 2-adrenoceptor antagonist on guinea-pig submucous neurones. Br J Pharmacol 92: 341-347
11. De Vivo M, Maayani S (1986) Characterization of the 5-hydroxytryptamine 1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes. J Pharmacol Exp Ther 238: 248-253
12. Fowler CJ, Ahlgren PC, Brannstrom G (1991) Antagonism by 8-hydroxy-2(di-n-propylamino)tetraline and other serotonin agonists of muscarinic M1-type receptors coupled to inositol phospholipid breakdown in human IMR-32 and SK-N-MC neuroblastoma cells. Life Sci 48: 959-967
13. Fozard JR, Kilbinger H (1985) 8-OH-DPAT inhibits transmitter release from guinea-pig enteric cholinergic neurons by activating 5-HT1A receptors. Br J Pharmacol 67: 601P
14. 1A receptor agonists in guinea pig ileum. J Pharmacol Exp Ther 260: 306-312
15. Gherezghiher T, March WF, Nordquist RE, Koss MC (1986) Laser-induced glaucoma in rabbits. Exp Eye Res 43: 885-894
16. Hill SJ, Kendall DA (1989) Cross-talk between different receptor-effector systems in the mammalian CNS. Cell Signal 1: 135-141
17. Hirose A, Sasa M, Akaike A, Takaori S (1990) Inhibition of hippocampal CA1 neurons by 5-hydroxytryptamine, derived from the dorsal raphe nucleus and the 5-hydroxytryptamine1A agonist SM-3997. Neuropharmacology 29: 93-101
18. Hong Y, Krnjevic K (1989) Serotonin blocks the facilitatory action of muscarinic and nicotinic agents in the hippocampus in vivo. Can J Physiol Pharmacol 67: 47-53
19. Kaufman PL (1984) Mechanisms of actions of the cholinergic drugs in the eye. In: Drance SM, Neufeld AH (eds) Glaucoma: applied pharmacology in medical treatment. Grune & Stratton, Orlando, pp 395-427
20. Mallorga P, Babilon RW, Buisson S, Sugrue MF (1989) Muscarinic receptors of the albino rabbit ciliary process. Exp Eye Res 48: 509-522
21. Miichi H, Nagataki S (1983) Effects of pilocarpine, salbutamol, and timolol on aqueous humor formation in cynomolgus monkeys. Invest Ophthalmol Vis Sci 24: 1269-1275
22. Moro F, Scapagnini U, Scaletta S, Drago F (1981) Serotonin nerve endings and regulation of pupillary diameter. Ann Ophthalmol 13: 487-490
23. Munson PJ, Rodbard D (1980) Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107: 220-239
24. Nardin GF, Zimmerman TJ, Zalta AH, Felts K (1989) Ocular cholinergic agents. In: Ritch R, Shields MB, Krupin T (eds) The glaucomas, vol 1. Mosby, St. Louis, pp 515-521
25. Osborne NN, Tobin AB (1987) Serotonin-accumulating cells in the iris-ciliary body and cornea of various species. Exp Eye Res 44: 731-745
26. 1A receptors have similar functions in the control of intraocular pressure (IOP) in the rabbit? Ophthalmologica 210: 308-314
27. 1A receptors and differential coupling to second messengers in CHO cells. Naunyn Schmiedebergs Arch Pharmacol 346: 127-137
28. 1A and muscarinic acetylcholine receptors jointly regulate passive avoidance behavior. Eur J Pharmacol 262: 77-90
29. Samochocki M, Strosznajder J (1995) The negative coupling between serotonin and muscarinic receptor(s) for arachidonic acid and inositol phosphates release in brain cortex synaptoneurosomes. Effect of aging. Neurochem Int 26: 571-578
30. Schoeffter P, Hoyer D (1988) Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br J Pharmacol 95: 975-985
31. Spencer DG Jr, Horvath E, Traber J (1986) Direct autoradiographic determination of M1 and M2 muscarinic acetylcholine receptor distribution in the rat brain: relation to cholinergic nuclei and projections. Brain Res 380: 59-68
32. Tobin AB, Unger W, Osborne NN (1988) Evidence for the presence of serotonergic nerves and receptors in the iris-ciliary body complex of the rabbit. J Neurosci 8: 3713-3721
33. Uusitalo H, Lehtosalo J, Laakso J, Harkonen M, Palkama A (1982) Immunohistochemical and biochemical evidence for 5-hydroxytryptamine containing nerves in the anterior part of the eye. Exp Eye Res 35: 671-675
34. Verge D, Daval G, Marcinkiewicz M, Patey A, el Mestikawy S, Gozlan H, Hamon M (1986) Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J Neurosci 6: 3474-3482
35. Woldemussie E, Feldmann BJ, Chen J (1993) Characterization of muscarinic receptors in cultured human iris sphincter and ciliary smooth muscle cells. Exp Eye Res 56: 385-392
36. Zifa E, Fillion G (1992) 5-Hydroxytryptamine receptors. Pharmacol Rev 44: 401-458