Use of D-myo inositol 1,2,6 trisphosphate to inhibit contractile activity in rat ventricular cardiomyocytes induced by neuropeptide Y and other cardioactive peptides through phospholipase C

British Journal of Pharmacology

Volumn 122, Issue 8, 1997, Pages 1655-1660

  Bell, David ^a   Millar, B Cherie ^a   McDermott, Barbara J ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Calcitonin gene related peptide; Contractile function; D myo inositol 1,2,6 trisphosphate; Endothelin 1; Neuropeptide Y; Phospholipase C; Pp56; Rat ventricular cardiomyocytes; Vasoactive intestinal peptide

Indexed keywords

4 AMINOPYRIDINE; CALCITONIN GENE RELATED PEPTIDE; CALCIUM ION; ENDOTHELIN 1; FORSKOLIN; INOSITOL 1,2,6 TRISPHOSPHATE; ISOPRENALINE; NEUROPEPTIDE Y; NORADRENALIN; PHOSPHOLIPASE C; PROPRANOLOL; SECRETIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE WALL; IMAGE ANALYSIS; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; SECOND MESSENGER;

ANIMALS; APPETITE STIMULANTS; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART; HEART VENTRICLES; INOSITOL PHOSPHATES; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; NEUROPEPTIDE Y; PEPTIDES; PHOSPHOLIPASE C; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; STIMULATION, CHEMICAL;

EID: 0031434385     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701567     Document Type: Article

References (35)

1. ADAMSSON, M., FALLGREN, B. & EDVINSSON, L. (1992). Inhibition of neuropeptide Y-induced potentiation of noradrenaline-induced vasoconstriction by pp56. Br. J. Pharmacol., 105, 93-96.
2. BELL, D. & McDERMOTT, B.J. (1994a). Secretin and VIP are potent stimulants of cellular contraction and the accumulation of cyclic AMP in rat ventricular cardiomyocytes. J. Cardiovasc. Pharmacol., 23, 959-969.
3. BELL, D. & McDERMOTT, B.J. (1994b). Use of the cyclic AMP antagonist, Rp-cAMPS, to distinguish between cyclic AMP-dependent and cyclic AMP-independent contractile responses in rat ventricular cardiomyocytes. J. Mol. Cell. Cardiol., 26, 1439-1448.
4. BELL, D. & McDERMOTT, B.J. (1994c). Calcitonin gene-related peptide stimulates a positive contractile response in rat ventricular cardiomyocytes. J. Cardiovasc. Pharmacol., 23, 1011-1021.
5. BELL, D. & McDERMOTT, B.J. (1996). Calcitonin gene-related peptide in the cardiovascular system: characterization of receptor populations and their (patho)physiological significance. Pharmacol. Rev., 48, 253-288.
6. BELL, D., SCHLUTER, K.D., ZHOU, X.J., McDERMOTT, B.J. & PIPER, H.M. (1995). Hypertrophic effects of CGRP and amylin on adult mammalian ventricular cardiomyocytes. J. Mol. Cell. Cardiol., 27, 2433-2443.
7. BRODDE, O.E., MICHEL, M.C. & ZEROWSKI, H.R. (1995). Signal transduction mechanisms controlling cardiac contractility and their alterations in chronic heart failure. Cardiovasc. Res., 30, 570-584.
8. 1-adrenoceptor signal transduction in the adult rat cardiac myocyte. In Biology of Isolated Cardiac Myocytes. ed. Clark, W.A. pp. 248-252. Amsterdam: Elsevier Science Publishing Co.
9. DEJONGE, H.W., VANHEUGTEN, H.A.A. & LAMERS, J.M.J. (1995). Signal transduction by the phosphatidylinositol cycle in myocardium. J. Mol. Cell. Cardiol., 27, 93-106.
10. DEY, M., MICHALKIEWICZ, M., HUFFMAN, L. & HEDGE, G.A. (1993). Sympathetic thyroidal vasoconstriction is not blocked by a neuropeptide Y antagonist or antiserum. Peptides, 14, 1179-1186.
11. ECKEL, J., GERLACH-ESKUCHEN, E. & REINAUER, H. (1991). Alpha-adrenoceptor-mediated increase in cytosolic free calcium in isolated cardiac myocytes. J. Mol. Cell. Cardiol., 23, 617-625.
12. EDVINSSON, L., ADAMSSON, M. & JANSEN, I. (1990). Neuropeptide antagonistic properties of pp56 in guinea pig basilar arteries. Neuropeptides, 17, 99-105.
13. FETH, F., ERDBRUGGER, W., RASCHER, W. & MICHEL, M.C. (1993). Is pp56 (D-myo-inositol 1,2,6 trisphosphate) an antagonist at neuropeptide Y receptors? Life Sci., 52, 1835-1844.
14. HARTZELL, H.C., MERY, P.F., FISCHMEISTER, R. & SZABO, G. (1991). Sympathetic regulation of cardiac calcium current is due exclusively to cyclic AMP-dependent phosphorylation. Nature, 351, 573-576.
15. 2+ exchange. Eur. J. Pharmacol., 186, 29-40.
16. KAKU, T., LAKATTA, E. & FILBURN, C. (1991). α-Adrenergic regulation of phosphoinositide metabolism and protein kinase C in isolated cardiac myocytes. Am. J. Physiol., 260, C635-C642.
17. KAMEYAMA, M., HOFMANN, F. & TRAUTWEIN, W. (1985). On the mechanism of β-adrenergic regulation of calcium channels in guinea pig heart. Pflugers Arch., 405, 285-293.
18. KELSO, E.J., McDERMOTT, B.J. & SILKE, B. (1993). Cardiotonic actions of selective phosphodiesterase inhibitors in rat isolated cardiomyocytes. Br. J. Pharmacol., 110, 1387-1394.
19. LI, T. & SPERELAKIS, N. (1983). Stimulation of slow action potentials in guinea pig papillary muscles by intracellular injection of cyclic AMP, Gpp(NH)p and cholera toxin. Circ. Res., 52, 111-117.
20. McDERMOTT, B.J., MILLAR, B.C. & PIPER, H.M. (1993). Cardiovascular effects of neuropeptide Y: receptor interactions and cellular mechanisms. Cardiovasc. Res., 27, 893-905.
21. MILLAR, B.C., WEIS, T., PIPER, H.M., WEBER, M., BORCHARD, U., McDERMOTT, B.J. & BALASUBRAMANIAM, A. (1991). Positive and negative contractile effects of neuropeptide Y on ventricular cardiomyocytes. Am. J. Physiol., 261, H1727-H1733.
22. PERNOW, J., MODIN, A. & LUNDBERG, J.M. (1992). No effect of D-myo-inositol 1,2,6-trisphosphate on vasoconstriction evoked by NPY and nonadrenergic sympathetic nerve stimulation. Eur. J. Pharmacol., 222, 171-174.
23. PIPER, H.M., PROBST, I., SCHWARTZ, P., HÜTTER, J.F. & SPIECKERMANN, P.G. (1982). Culturing of calcium stable adult cardiac myocytes. J. Mol. Cell. Cardiol., 14, 397-412.
24. PIPER, H.M., MILLAR, B.C. & McDERMOTT, B.J. (1989). The negative inotropic effect of neuropeptide Y on the ventricular cardiomyocyte. Naunyn Schmiedberg's Arch. Pharmacol., 340, 333-337.
25. RALEVIC, V., EDVINSSON, L. & BURNSTOCK, G. (1994). Inhibition of neuropeptide Y-induced augmentation of noradrenaline-induced vasoconstriction by pp56 in the rat mesenteric arterial bed. Acta Physiol. Scand., 151, 309-317.
26. SUN, X.Y., EDVINSSON, L. & HEDNER, T. (1991). NPY-induced pressor responses in spontaneously hypertensive and Wistar-Kyoto rats antagonized by D-myo-inositol 1,2,6 trisphosphate (pp56). J. Hypertension, 9, S344-S345.
27. SUN, X.Y., EDVINSSON, L. & HEDNER, T. (1992). Effects of pp56 on NPY-induced potentiation of various vasoconstrictor agents in the rat. J. Pharmacol. Exp. Ther., 261, 1147-1152.
28. SUN, X.Y., EDVINSSON, L. & HEDNER, T. (1994). Histamine-independent modulation of the neuropeptide Y-induced pressor response by α-trinositol in the pithed rat. Pharmacol. Toxicol., 75, 371-376.
29. SUN, X.Y., EDVINSSON, L., YOO, H., WAHLESTEDT, C. & HEDNER, T. (1995). Effects of some novel D-myo-inositol phosphate derivatives on binding and sympathetic transmission. J. Cardiovasc. Pharmacol., 25, 696-704.
30. 1-adrenoceptors: an overview. Pharmacol. Rev., 45, 147-175.
31. WAHLESTEDT, C., REIS, D.J., YOO, H., ADAMSSON, M., ANDERSON, D. & EDVINSSON, L. (1992). A novel inositol phosphate selectively inhibits vasoconstriction evoked by the sympathetic co-transmitters NPY and ATP. Neurosci. Lett., 143, 123-126.
32. 3H]-α-trinositol binding sites in human and mammalian tissues. J. Pharmacol. Exp. Ther., 273, 461-469.
33. WINTER, K., MYRUP, B., OLSEN, J. & HEDMAN, C. (1989). pp56 inhibits thrombin-induced aggregation of human platelets from diabetics and healthy volunteers - an in vitro study. Thromb. Haemostas., 62, 559 (Abstract).
34. XIANG, H. & BROWN, J.C. (1993). Inhibitory effect of neuropeptide Y and its analogues on inositol 1,4,5 trisphosphate level in rat cardiomyocytes. Receptors Channels, 1, 315-321.
35. YOO, H., FALLGREN, B., LINDAHL, A. & WAHLESTEDT, C. (1994). Characterization of specific binding sites for pp56 in rat heart. Eur. J. Pharmacol., 268, 55-63.