Lactate infusion to normal rats during hyperglycemia enhances in vivo muscle glycogen synthesis

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 273, Issue 6 42-6, 1997, Pages

  Pagano, Claudio ^a   Granzotto, Maenie ^a   Giaccari, Andrea ^b   Fabris, Roberto ^a   Serra, Roberto ^a   Lombardi, Anna Maria ^a   Federspil, Giovanni ^a   Vettor, Roberto ^a,c  

^a UNIVERSITY OF PADOVA   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c Univ Padova Via Osp 105 35128 P   (Italy)

Author keywords

Glucose; Glycolysis; Insulin secretion; Insulin sensitivity

Indexed keywords

BICARBONATE; GLYCOGEN; INSULIN; LACTATE SODIUM; LACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUCOSE HOMEOSTASIS; GLUCOSE UTILIZATION; GLYCOGEN SYNTHESIS; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN RELEASE; INSULIN SENSITIVITY; LACTATE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

EID: 0031430743     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1997.273.6.r2072     Document Type: Article

References (11)

1. Agius, L., M. Peak, and K. G. M. M. Alberti. Regulation of glycogen synthesis from glucose and gluconeogenic precursors by insulin in periportal and perivenous rat hepatocytes. Biochem. J. 266: 91-102, 1990.
2. Ahlborg, G., L. Hagenfeldt, and J. Wahren. Influence of lactate infusion on glucose and FFA metabolism in man. Scared. J. Clin. Lab. Invest. 36: 193-201, 1976.
3. Bonadonna, R. C., S. Del Prato, E. Bonora, G. Gulli, A. Solini, and R. A. DeFronzo. Effects of physiological hyperinsulinemia on the intracellular metabolic partition of plasma glucose. Am. J. Physiol. 265 (Endocrinol Metab. 28): E943-E953, 1993.
4. Chan, T. M., and J. H. Exton. A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes. Anal. Biochem. 71: 96-105, 1976.
5. Christopher, M. J., C. Rantzau, G. M. Ward, and F. P. Alford. Impact of variable insulinemia and glycemia on in vivo glycolysis and glucose storage in dogs. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E62-E71, 1994.
6. Clark, P., A. Jenkins, and E. W. Kraegen. Pentobarbital reduces basal liver glucose output and its insulin suppression in rats. Am. J. Physiol. 258 (Endocrinol. Metab. 21): E701-E707, 1990.
7. Consoli, A., N. Nurjahan, J. E. Gerich, and L. Mandarine. Skeletal muscle is a major site of lactate uptake and release during hyperinsulinemia. Metabolism 41: 176-179, 1992.
8. Corsi, A., M. Zatti, M. Midrio, and A. L. Granata. In situ oxidation of lactate by skeletal muscle during intermittent exercise. FEES Lett. 11: 65-68, 1970.
9. Drake, A. J., J. R. Haines, and M. I. M. Noble. Preferential uptake of lactate by the normal myocardium in dogs. Cardiovasc. Res. 14: 65-72, 1980.
10. Farrace, S., and L. Rossetti. Hyperglycemia markedly enhances skeletal muscle glycogen synthase activity in diabetic but not in normal conscious rats. Diabetes 41: 1453-1463, 1992.
11. Federspil, G., M. Zaccaria, S. Pedrazzoli, E. Zago, C. De Palo, and C. Scandellari. Effects of sodium DL-lactate on insulin secretion in anesthetized dogs. Diabetes 29: 33-36, 1980.