Testosterone is locally metabolized in human brain tumors, with possible qualitative and quantitative changes in its effects

Neuroendocrinology Letters

Volumn 18, Issue 4, 1997, Pages 203-213

  Stuerenburg, Hans Joerg ^a   Breivik, Ingevild ^a   Puchner, Maximilian J A ^a   Lohmann, Frauke ^a   Kunze, Klaus ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANDROSTENEDIONE; AROMATASE; BRAIN ENZYME; ESTROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; OXIDOREDUCTASE; PROGESTERONE RECEPTOR; STEROID 5ALPHA REDUCTASE; STEROID RECEPTOR; TESTOSTERONE; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; ASTROCYTOMA; BRAIN TUMOR; CANCER GRADING; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG TRANSFORMATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GLIOBLASTOMA; HAMARTOMA; HUMAN; HUMAN TISSUE; MALE; MENINGIOMA; NEURILEMOMA; OLIGODENDROGLIOMA; STEROID METABOLISM; TARGET ORGAN; TESTOSTERONE METABOLISM;

EID: 0031430564     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Bartsch W, Klein H Stürenburg HJ et al. (1987) Metabolism of androgens in human benign prostate hyperplasia: aromatase and its Inhibition J. Steroid Biochem 27 557-564
2. Blankenstein MA, Blaauw G, Lamberts SWJ (1984) Progestin and estrogen receptors in human meningioma Clin Neuropharmacol 7 363-367
3. Bruchovsky N, Wilson JD (1968) The conversion of testosterone to 5-alpha-androstane-17β-ol-3-one by rat prostate in vivo and in vitro J. Biol Chem 243, 2012-2021
4. Brueggemeier RW Snider CE Counsell RE (1982) Substituted C19 steroid analogues as inhibitors of aromatase. Cancer Res. 42, 3334-3337
5. Celotti F, Massa R, Martini L. Metabolism of sex steroids in the central nervous system (1979) In: Endocrinology (Edited by L.J. De Groot) Grune and Stratton. New York: p. 41
6. Celotti F, Melcangi RC, Negri-Cesi P, Ballabio M, Martini L (1987) Differential distribution of 5-alpha-reductase in the central nervous system of the rat and the mouse: Are the white matter structures of the brain target tissue for testosterone action? Steroid. Biochem. 26, 125-129
7. Denef C, Magnus C, McEwen B (1973) Sex differences and hormonal control of testosterone metabolism in rat pituitary and brain. J. Endocrinol. Metab., 59, 605-621.
8. Frederiksen DW, Wilson JD (1971) Partial charakterization of the nuclear reducted nicotinamide adenine dinucleotide phosphate: delta-3-ketosteroid-5-alpha-oxidoreductase of rat prostate. J Biol Chem. 246, 2584-2593.
9. Gabos S, Berkel J (1992) Meta-analysis of progestin and estrogen receptors in human meningeomas Neuroepidemiology, 11, 255-260.
10. Goy RW, McEwen BS (1980) Sexual differentiation of the brain. MIT Press, Cambridge, MA. pp 131-139
11. Jaffe RB (1969). Testosterone metabolism in target tissues: hypothalamic and pituitary tissues of the adult rat and human fetus, and the immature rat epiphysis. Steroids, 14, 483-489
12. Kao LWL, Lloret AP, Weisz J (1977) Metabolism in vitro of dihydrotestosterone, 5-alpha-androstane 3-alpha, 17β-diol and its 3β-epimer, three metabolites of testosterone, by three of its target tissues, the anterior pituitary, the medial basal hypothalamus and the seminiferous tubules J. Steroid. Biochem., 8, 1109-1115.
13. Kleihues P, Burger PC, Scheithauer BW (1993) The new WHO classification of brain tumours Brain Pathology, 3, 255-268.
14. Klein H, Bressel M, Kastendieck H, et al (1988) Quantitative assessment of endogeneous testicular and adrenal sex steroids and of steroid metabolizing enzymes in untreated human prostatic cancerous tissue. J. Steroid. Biochem., 30, 119-130.
15. Kniewald Z, Massa R, Martini L (1971) Conversion of testosterone into 5-alpha-androstane-17β-ol-3-one at the anterior pituitary and hypothalamic level. In: Hormonal Steroids, Proceedings of the Third International Congress on Hormonal Steroids (Edited by VHT James and L Martini) Excerpta Medica International Congress Series, 219, Amsterdam, 784-791.
16. Krieg M, Klōtzl G, Kaufmann J et. al. (1981) Stroma of human benign prostatic hyperplasia: preferential tissue for androgen metabolism and oestrogen binding. Acta Endocrinol., 96, 422-432.
17. Krieg M, Bartsch W, Thomsen M et. al. (1963) Androgens and estrogens: their interaction with stroma and epithelium of human benign prostatic hyperplasia and normal prostate. J. Steroid Biochem, 19, 155-161.
18. Krieger NR, Scott RG (1984) 3-alpha-hydroxysteroid oxidoreductase in rat brain. J. Neurochem., 42, 887-890.
19. Krieger NR, Scott RG, Jurman ME (1983) Testosterone-5-alpha reductase in rat brain. J. Neurochem., 40, 1460-1464.
20. Lieberburg I, MacLusky NJ, Mc Ewen BS (1977) 5-alpha-dihydrotestosterone (DHT) receptors in rat brain and pituitary cell nuclei. Endocrinology, 100, 598-607.
21. Magdalenat H, Pertuiset BF, Poisson M et. al. (1982) Progestin and oestrogen receptors in meningiomas. Biochemical characterisation, clinical and pathological correlations in 42 cases Acta Neurochir., 64, 199-213
22. Magrassi L, Bono F, Milanesi G et. al (1992) Vitamin D receptor expression in human brain tumors J. Neurosurg Sci., 36, 27-30
23. Martini L. (1982) The 5-alpha-reduction of testosterone in the neuroendocrine structures Biochemical and physiological implications. Endocr. Rev., 3, 1-25
24. Massa R, Stupnicka E, Kniewald, Z et. al. 1972) The transformation of testosterone into dihydrotestosterone by the brain and the anterior pituitary J. Steroid. Biochem., 385-399
25. Maxwell M, Galanopoulos T, Neville-Golden J et. al. (1972) Expression of androgen and progesterone receptors in primary human meningiomas. J. Neurosurg., 78, 455-462.
26. Moore RJ, Wilson JD (1974) Extraction of the reducted nicotinamide adenine dinucleotide phosphate: delta-3-ketosteroid-5-alpha-oxidoreductase of rat prostate with digitonin and potassium chloride Biochemistry, 13, 450-455.
27. O'Malley BW, Means AR (1974) Female steroid hormones and target cell nuclei Science, 183, 610-620.
28. Paoletti P, Butti G, Zibera C (1990) Characteristics and biological role of steroid receptors in neuroepithelial tumors. J. Neurosurg., 73, 736-742.
29. Poisson M, Pertuiset BF, Hauw JJ (1983) Steroid hormone receptors in human meningiomas, gliomas and brain metastases. J. Neurooncol., 1, 179-189.
30. Reed KC, Ohno S (1976) Kinetic properties of human placental aromatase. J. Biol. Chem, 251, 1625-1631.
31. Rommerts FFG, Van der Molen HJ (1971) Occurance and localization of 5-alpha steroid reductase, 3-alpha- and 17-beta-hydroxysteroid dehydrogenases in hypothalamus and other brain tissues of the male rat Biochim. Biophys. Acta, 248, 489-502.
32. Schmidt H, Noak I, Voigt KD (1972) Metabolism and mode of action of androgens in target tissues of male rats. II: Mode of action of testosterone and 5-alpha-dihydrotestosterone at a cellular level on seminal vesicles and prostates of the rat Acta Endocrinol, 69, 165-173.
33. von Schoultz E, Bixo M, Backstrom T. et. al. (1990) Sex steroids in human brain tumors and breast cancer. Cancer, 55, 949-52.
34. Verhoeven G, Demoor P (1972) Kinetic data on the formation of 17-beta-hydroxy-5-alpha-androstane-3-one in renal nuclei from male and female rats. Endocrinology, 91, 54-64.
35. Walsh PC, Wilson JD (1976). The induction of prostatic hypertrophy in the dog with androstanediol. J. Clin Invest., 57, 1093-1097
36. Weidenfels J, Schiller H (1984) Metabolisation of steroids by human brain tumors Clin Neuropharm 7 395-7
37. Weismann AS, Raguet SS Kelly PA (1987) Characterisation of epidermal growth factor receptors in human meningiomas. Cancer Res, 476, 2172-2176