Metabolite mean transit times in the liver as predicted by various models of hepatic elimination

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 25, Issue 4, 1997, Pages 477-505

  Mellick, George D ^a   Anissimov, Yuri G ^a   Bracken, Anthony J ^a   Roberts, Michael S ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Area under curve; Dispersion model; Distributed tube model; Hepatic elimination models; Hepatocyte permeability; Impulse response; Mean transit time; Metabolite kinetics; Normalized variance

Indexed keywords

ACETYLSALICYLIC ACID; SALICYLIC ACID;

ANIMAL TISSUE; AREA UNDER THE CURVE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG ELIMINATION; LIVER CELL; LIVER CLEARANCE; NONHUMAN; NOTE; PRIORITY JOURNAL; RAT; REGIONAL PERFUSION;

ANIMALS; HUMANS; LIVER; MODELS, BIOLOGICAL; PERMEABILITY; TIME FACTORS;

EID: 0031430438     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025797126763     Document Type: Note

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