Induction of cathepsin D protein during estrogen carcinogenesis: Possible role in estrogen-mediated kidney tubular cell damage

Carcinogenesis

Volumn 18, Issue 7, 1997, Pages 1375-1380

  Li, Sara Antonia ^a   Liao, De Zhong Joshua ^a   Yazlovitskaya, Eugenia M ^a   Pantazis, Cooley G ^b   Li, Jonathan J ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; CATHEPSIN D; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; ISOENZYME; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HAMSTER; HORMONAL CARCINOGENESIS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULE DAMAGE; KIDNEY TUMOR; MALE; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RECEPTOR DENSITY;

ANIMALS; CATHEPSIN D; CRICETINAE; ENZYME INDUCTION; ESTROGENS; KIDNEY NEOPLASMS; KIDNEY TUBULES; MALE; MESOCRICETUS; RECEPTORS, ESTROGEN;

EID: 0031428479     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.7.1375     Document Type: Article

References (34)

1. Gonzalez, A., Oberley, T.D. and Li, J.J. (1989) Morphological and immunohistochemical studies of the estrogen-induced Syrian hamster renal tumor: Probable cell of origin. Cancer Res., 49, 1020-1028.
2. Li, J.J., Gonzalez, S., Banerjee, S.K. and Li, S.A. (1993) Estrogen carcinogenesis in the hamster kidney: role of cytotoxicity and cell proliferation. Environ. Hlth Perspect., 101 (suppl. 5), 259-264.
3. Nelson, S.D., Mitchell, J.R., Dybing, E. and Sasame, H.A. (1976) Cytochrome p-450-mediated oxidation of 2-hydroxy-estrogens to reactive intermediates. Biochem. Biophys. Res. Commun., 70, 1157-1165.
4. Tsibris, J.C.M. and McGuire, P.M. (1977) Microsomal activation and binding to nucleic acids and proteins. Biochem. Biophys. Res. Commun., 78, 411-417.
5. Horning, E.C., Thenot, J.-P. and Helton, E.D. (1978) Toxic agents resulting from the oxidative metabolism of steroid hormones and drugs. J. Toxicol. Environ. Hlth, 4, 341-361.
6. Brueggemeier, R.W., Kimbally, J.G. and Kraft, F. (1984) Estrogen metabolism in rat liver microsomal and isolated hepatocyte preparations. I. Metabolite formation and irreversible binding to cellular macromolecules. Biochem. Pharmacol., 33, 3853-3859.
7. 14C]estrone in hamster and rat hepatic and renal microsomes: Species-, sex-, and age-specific differences. J. Steroid Biochem., 42, 389-397.
8. Weisz, J., Bui, Q.D., Roy, D. and Liehr, J.G. (1992) Elevated 4-hydroxylation of estradiol by hamster kidney microsomes: a potential pathway of metabolic activation of estrogens. Endocrinology, 31, 655-661.
9. Zhu, T.B., Bui, Q.D., Weisz, J. and Liehr, J.G. (1994) Conversion of estrone to 2-and 4-hydroxyestrone by hamster kidney and liver microsomes: implications for the mechanism of estrogen-induced carcinogenesis. Endocrinology, 13, 1772-1775.
10. Li, S.A., Xue, Y., Xie, Q., Li, C.I. and Li, J.J. (1994) Serum and tissue levels of estradiol during estrogen-induced renal tumorigenesis in the Syrian hamster. J. Steroid Biochem. Molec. Biol., 48, 283-286.
11. Li, J.J., Talley, D.J., Li, S.A. and Villee, C.A. (1974) An estrogen binding protein in the renal cytosol of the intact, castrated, and estrogenized golden hamsters. Endocrinology, 9, 1134-1141.
12. Li, S.A., Li, J.J. and Villee, C.A. (1977) Significance of the progesterone receptor in the estrogen-induced and -dependent renal tumor of the Syrian golden hamster. Ann. N.Y. Acad. Sci., 286, 369-383.
13. Li, J.J. and Li, S.A. (1984) Estrogen-induced tumorigenesis in the Syrian hamster: roles for hormonal and carcinogenic activities. Arch. Toxicol., 55, 110-118.
14. Oberley, T.D., Lauchner, L.J., Pugh, T.D., Gonzalez, A., Goldfarb, S., Li, S.A. and Li, J.J. (1989) Specific estrogen-induced cell proliferation of cultured Syrian hamster renal proximal tubular cells in serum-free chemically defined media. Proc. Natl Acad. Sci. USA, 86, 2107-2111.
15. Westley, B. and Rochefort, H. (1980) A secreted glycoprotein induced by estrogen in human breast cancer cell lines. Cell, 20, 353-362.
16. Schultz, D.C, Bazel, S., Wright, L.M., Tucker, S., Lange, M.K., Tachovsky, T., Longo, S., Niedbula, S. and Alhadeff, J.A. (1994) Western blotting and enzymatic activity analysis of cathepsin D in breast tissue and sera of patients with breast cancer and benign breast disease. Cancer Res., 54, 48-54.
17. Capony, F., Rougeot, C., Mountcourrier, P., Cavailles, V., Salazar, G. and Rochefort, H. (1989) Increased secretions altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells. Cancer Res., 49, 3904-3909.
18. Rochefort, H. (1992) Cathepsin D in breast cancer: a tissue marker associated with metastasis. Eur. J. Cancer, 28A, 1780-1783.
19. Schwartz, M.K. (1995) Tissue cathepsins as tumor markers. Clin. Chim. Acta, 237, 67-68.
20. Li, J.J., Kirkman, H. and Hunter, R.L. (1969) Sex difference and gonadal hormone influence on Syrian hamster kidney esterase isozymes. J. Histochem. Cytochem., 17, 386-393.
21. Li, J.J., Li, S.A., Klicka, J.K., Parsons, J.A. and Lam, L.K.T. (1983) Relative carcinogenic activity of various synthetic and natural estrogens in the hamster kidney. Cancer Res., 43, 5200-5204.
22. Taylor, C.R., Shi, S.R., Chaiwun, B., Young, L., Imam, S.A. and Cote, R.J. (1994) Immunohistochemical staining of various intranuclear prognostic markers in formalin-paraffin sections: androgen receptor, estrogen receptor, progesterone receptor, p53 protein, proliferating cell nuclear antigen, and Ki-67 antigen revealed by antigen retrieval techniques. Hum. Pathol., 25, 263-270.
23. Coe, F.M. and Sweeney, G.D. (1980) Changes in rat hepatoyte plasma membranes caused by synthetic estrogens. Lab. Invest., 42, 225-230.
24. Greenman, D.L., Gaylor, D., Highman, B., Farmer, J., Norvell, M.J. and Gass, G. (1983) Nonneoplastic changes induced in female C3H mice by chronic exposure to diethylstilbestrol or 17β-estradiol. J. Toxicol. Environ. Hlth, 11, 843-856.
25. Bern, H.A., Mills, K.T. and Jones, L.A. (1983) Critical period for neonatal estrogen exposure in occurrence of mammary gland abnormalities in adult mice. Proc. Soc. Exptl. Biol. Med., 172, 239-242.
26. Hou, X., Li, J.J., Chen, W. and Li, S.A. (1996) Estrogen-induced proto-oncogene and suppressor gene expression in the hamster kidney: Significance for estrogen carcinogenesis. Cancer Res., 56, 2616-2620.
27. Liao, D.J, Li, J.J., Hou, X. and Li, S.A. (1997) Characterization of c-myc and c-fos expression and c-MYC protein levels during estrogen-induced renal carcinogenesis in the Syrian hamster. Mol. Carcinogenesis, submitted.
28. Augerau, P., Miralles, F., Cavailles, V., Goudelef, C., Parker, M. and Rochefort, H. (1994) Characterization of the proximal estrogen-responsive element of human cathepsin D gene. Mol. Endocrinol., 8, 693-703.
29. Kristensen, G.B., Holm, R., Abeler, V.M. and Trope, C.G. (1996) Evaluation of the prognostic significance of cathepsin D, epidermal growth factor, and c-erbB2 in early cervical squamous cell carcinoma. Cancer, 78, 433-440.
30. Valentini, A.M., Pirrelli, M., Arementano, R. and Caruso, M.L. (1996) The immunohistochemical expression of cathepsin D in colorectal cancer. Anticancer Res., 16, 77-80.
31. Maudelonde, T., Martinez, P., Brouillet, J.-P., Laffargue, F., Pages, A. and Rochefort, H. (1990) Cathepsin D in human endometrium: induction by progesterone and potential value as a tumor marker. Endocrinol. Metab., 70, 115-121.
32. Gieselmann, V., Hasilik, A. and Von Figura, K. (1985) Processing of human cathepsin D in lysosomes in vitro. J. Biol. Chem., 360, 3215-3220.
33. Yonezawa, S., Takahashi, T., Wang, X.-J., Wong, R.N.S., Hartsuck, J.A. and Tong, J. (1988) Structures at the proteolytic processing region of cathepsin D. J. Biol. Chem., 263, 16504-16511.
34. Li, J.J. and Li, S.A. (1996) Estrogen carcinogenesis in the hamster kidney: a hormone-driven multistep process. In Huff, J., Boyd, J. and Barrett, J.C. (eds) Cellular and Molecular Mechanisms of Hormonal Carcinogenesis: Environmental Influences. Wiley-Liss, Inc., Philadelphia, PA, pp. 255-267.