Improvement of impaired glucose tolerance by oral administration of vanadyl sulfate by gavage in streptozotocin-induced diabetic rats

Research Communications in Molecular Pathology and Pharmacology

Volumn 98, Issue 2, 1997, Pages 190-200

  Tsunajima, Takahiko ^a   Tatsuki, Rie ^a   Satoh, Kumi ^a   Yamamoto, Atsuko ^a   Hoshi, Katsuji ^a   Ichihara, Kazuo ^a,b  

^a HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

VANADYL SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; FEEDING; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; INSULIN; INTUBATION, GASTROINTESTINAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; VANADIUM COMPOUNDS;

EID: 0031427822     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Cam, M.C., Pederson, R.A., Brownsey, R.W. and McNeil, J.H. (1993) Long-term effectiveness of oral vanadyl sulphate in streptozotocin-diabetic rats. Diabetologia 36, 218-224.
2. Dahlqvist, A. (1961) Determination of maltase and isomaltase activities with a glucose-oxidase reagent. Biochem. J. 80, 547-551.
3. Domingo, J.L., Sanchez, D.J., Gomez, M., Llobet, J.M, and Corbella, J. (1992) Administration of vanadyl sulfate by gavage does not normalize the blood glucose levels in streptozotocin-induced diabetic rats. Res. Commun. Chem. Pathol. Pharmacol. 75, 369-372.
4. Heyliger, C.E., Tahiliani, A.G. and McNeil, J.H. (1985) Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats. Science 227, 1474-1477.
5. Linder, A. (1972) Streptozotocin. Arzneim. Forsch. Drug Res. 22, 830-861.
6. Meyerovitch, J., Farfel, Z., Sack, J. and Shechter, Y. (1987) Oral administration of vanadate normalizes the blood glucose levels in streptozotocin-treated rats: Characterization and mode of action. J. Biol. Chem. 262, 6658-6662.
7. Mukherjee, B., Mukherjee, J.R. and Chatterjee, M. (1994) Lipid peroxidation, glutathione levels and changes in glutathione-related enzyme activities in streptozotocin-induced diabetic rats. Immunol. Cell Biol. 72, 109-114.
8. Pederson, R.A., Ramanadham, S. Buchan, A.M.J. and McNeil, J.H. (1989) Long-term effects of vanadyl treatment on streptozotocin-induced diabetes in rats. Diabetes 38, 1390-1395.
9. Rakieten, N., Rakieten, M.L. and Nadkarni, M.V. (1963) The diabetogenic action of streptozotocin. Cancer Chemother. Repts. 29, 91-98.
10. Ramanadham, S., Cros, G.H., Mongold, J.J., Serrano, J.J. and McNeil, J.H. (1990) Enhanced in vivo sensitivity of vanadyl-treated the diabetic rats to insulin. Can. J. Physiol. Pharmacol. 68, 486-491.
11. Ramanadham, S., Mongold, J.J., Brownsey, R.W., Gros, G.H. and McNeil, J.H. (1989) Oral vanadyl sulfate in the treatment of diabetes mellitus in the rat. Am. J. Physiol. 257, H904-H911.
12. Swarup, G., Cohen, S. and Garbers, D.L. (1982) Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate. Biochem. Biophys. Res. Commun. 107, 1104-1109.
13. 2 generation and DNA fragmentation in pancreatic islets. Diabetes 40, 1141-1145.
14. Tamura, S., Brown, T.A., Whipple, J.H., Fujita-Yamaguchi, Y., Dubler, R.E., Cheng, K. and Larner, J. (1984) A novel mechanism for the insulin-like effect of vanadate on glycogen synthase in rat adipocytes. J. Biol. Chem. 259, 6650-6658.
15. Tatsuki, R., Satoh, K., Yamamoto, A., Hoshi, K. and Ichihara, K. (1997) Lipid peroxidation in pancreas and other organs in streptozotocin diabetic rats. Japan. J. Pharmacol. 73, in press.
16. Venkatesan, N., Avidan, A. and Davidson, M.E. (1991) Antidiabetic action of vanadyl in rats independent of in vivo insulin receptor kinase activity. Diabetes 40, 492-498.