Decreased hepatocyte growth factor level by Wy-14,643, non-genotoxic hepatocarcinogen in F-344 rats

Carcinogenesis

Volumn 18, Issue 7, 1997, Pages 1303-1309

  Motoki, Yoshiteru ^a   Tamura, Hiroshi ^a   Morita, Rika ^a   Watanabe, Takafumi ^a   Suga, Tetsuya ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PIRINIXIC ACID; SCATTER FACTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; KIDNEY; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LUNG; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CARCINOGENS; HEPATOCYTE GROWTH FACTOR; KIDNEY; LIVER NEOPLASMS, EXPERIMENTAL; LUNG; MALE; PRECANCEROUS CONDITIONS; PYRIMIDINES; RATS; RATS, INBRED F344; RNA, MESSENGER;

EID: 0031427598     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.7.1303     Document Type: Article

References (36)

1. Reddy, J.K., Azamoff, D.L. and Hignite, C.E. (1980) Hypolipidemic hepatic peroxisome proliferators from a novel class of chemical carcinogens. Nature, 283, 397-398.
2. Reddy, J.K. and Lalwani, N.D. (1983) Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. CRC Crit. Rev. Toxicol., 12, 1-58.
3. Svoboda, D.J. and Azarnoff, D.L. (1966) Response of hepatic microbodies to a hypolipidemic agent, ethyl chlorophenoxyisobutyrate (CPIB). J. Cell. Biol., 30, 442-450.
4. Reddy, J.K. and Krishnakantha, T. (1975) Hepatic peroxisome proliferation: induction by two novel compounds structurally unrelated to clofibrate. Science, 190, 87-789.
5. Kluwe, W.M., Huff, J.E., Matthews, H.B., Irwin, R. and Haseman, J.K. (1985) Comparative chronic toxicities and carcinogenic potentials of 2-ethylhexyl-containing compounds in rats and mice. Carcinogensis, 6, 1577-1583.
6. Kawashima, Y., Katoh, H., Nakajima, S., Kozuka, H. and Uchiyama, M. (1984) Effects of 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyaceticacid on peroxisome enzymes in rat liver. Biochem. Pharmacol., 33, 242-245.
7. Leighton, B., Tagliafero, A.R. and Newscholme, E.A. (1987) The effect of dehydroepiandrosterone acetate on liver peroxisomal enzyme activities of male and female rats. J. Nutr., 117, 1287-1290.
8. Hayashi, F., Tamura, H., Yamada, J., Kasai, H. and Suga, T. (1994) Characteristics of the hepatocarcinogenesis caused by dehydroepiandrosterone, a peroxisome proliferator, in male F-344 rats. Carcinogenesis, 15, 2215-2219.
9. Hess, R., Stäubli, W. and Riess, W. (1965) Nature of the hepatomegalic effect produced by ethyl-chlorophenoxy-isobutyrate in the rat. Nature, 208, 856-858.
10. Lazarow, P.B. and De Duve, C. (1976) A fatty acyl-CoA oxidizing system in rat liver peroxisomes, enhancement by clofibrate, a hypolipidemic drug. Proc. Natl Acad. Sci. USA, 73, 2043-2046.
11. Osumi, T. and Hashimoto, T. (1978) Enhancement of fatty acyl CoA oxidizing activity in rat liver peroxisomes by di-(2-ethylhexyl)phthalate. J. Biochem. 83, 1361-1365.
12. Bieri, F., Bentley, P., Waechter, F. and Stäubli, W. (1986) Mitogenicity of peroxisome proliferators in monolayers of adult rat hepatocytes. Fd Chem. Toxic., 24, 709.
13. Marsman, D.S., Cattley, R.C., Conway, J.G. and Popp, J.A. (1988) Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]-acetic acid (Wy-14,643) in rats. Cancer Res., 48, 6739-6744.
14. Eacho, P.I., Lanier, T.L. and Brodhecker, C.A. (1991) Hepatocellular DNA synthesis in rats given peroxisome proliferating agents: comparison of WY-14 643 to clofibric acid, nafenopin and LY171883. Carcinogenesis, 12, 1557-1561.
15. Choen, S.M. and Ellwein, L.B. (1990) Cell proliferation in carcinogenesis. Science, 249, 972-975.
16. Nakamura, T., Nawa, K. and Ichihara, A. (1984) Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem. Biophys. Res. Commun., 122, 1450-1459.
17. Nakamura, T., Teramoto, H. and Ichihara, A. (1986) Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures. Proc. Natl Acad. Sci. USA., 83, 6489-6493.
18. Nakamura, T., Nawa, K., Ichihara, A., Kaise, N. and Nishimoto, T. (1987) Purification and subunit structure of hepatocyte growth factor from rat platelets. FEBS Lett., 224, 311-316.
19. Stoker, M., Gherardi, E., Perryman, M. and Gray, J. (1987) Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature (Lond.), 327, 239-242.
20. Weidner, K.M., Arakaki, N., Hartmann, G., et al. (1991) Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc. Natl Acad. Sci. USA., 88, 7001-7005.
21. Tajima, H., Matsumoto, K. and Nakamura, T. (1991) Hepatocyte growth factor has potent anti-proliferative activity in various tumour cell lines. FEBS Lett., 291, 229-232.
22. Shiota, G., Rhoads, D.B., Wang, T.C., Nakamura, T. and Schmidt, E.V. (1992) Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc. Natl Acad. Sci. USA., 89, 373-377.
23. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
24. Tashiro, K., Hagiya, M., Nishizawa, T., Seki, T., Shimonishi, M., Shimizu, S. and Nakamura, T. (1990) Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in the tissues. Proc. Natl Acad. Sci. USA., 87, 3200-3204.
25. Seglen, P.O. (1976) Preparation of isolated rat liver cells. Methods Cell Biol., 13, 29-83.
26. Kan, M., Zhang, G., Zarnegar, R., Michalopoulos, G., Myoken, Y., McKeehan, W.L. and Stevens, J.I. (1991) Hepatocyte growth factor/ hepatopoietin a stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE. Biochem. Biophys. Res. Commun., 174, 331-337.
27. Morimoto, A., Okamura, K., Hamanaka, R., Sato, Y., Shima, N., Higashio, K. and Kuwano, M. (1991) Hepatocyte growth factor modulates migration and proliferation of human microvascular endothelial cells in culture. Biochem. Biophys. Res. Commun., 179, 1042-1049.
28. Igawa, T., Kanda, S., Kanetake, H., Saitoh, Y., Ichihara, A., Tomita, Y. and Nakamura, T. (1991) Hepatocyte growth factor is a potent mitogen for cultured rabbit renal tubular epitherial cells. Biochem. Biophys. Res. Commun., 174, 831-838.
29. Higashio, K., Shima, N., Goto, M., Itagaki, Y., Nagao, M., Yasuda, H. and Morinaga, T. (1990) Identity of a tumour cytotoxic factor from human fibroblasts and hepatocyte growth factor. Biochem. Biophys. Res. Commun., 170, 397-404.
30. Kinoshita, T., Tashiro, K. and Nakamura, T. (1989) Marked increase of HGF mRNA in non-parenchymal liver cells of rats treated with hepatotoxins. Biochem. Biophys. Res. Commun., 165, 1229-1234.
31. Noji, S., Tashiro, K., Koyama, E., Nohno, T., Ohyama, K., Taniguchi, S. and Nakamura, T. (1990) Expression of hepatocyte growth factor gene in endothelial and Kupffer cells of damaged rat livers, as revealed by in situ hybridization. Biochem. Biophys. Res. Commun., 173, 42-47.
32. Matsumoto, K., Tajima, H., Okazaki, H. and Nakamura, T. (1992) Negative regulation of hepatocyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-β1 and glucocorticoids. J. Biol. Chem., 267, 2491-24920.
33. Rumsby, P.C., Davies, M.J., Price, R.J. and Lake, B.G. (1994) Effect of some peroxisome proliferators on transforming growth factor-β1 gene expression and insulin-like growth factor II/mannnose-6-phosphate receptor gene expression in rat liver. Carcinogenesis, 15, 419-421.
34. Yanagita, K., Nagaike, M., Ishibashi, H., Niho, Y., Matsumoto, K. and Nakamura, T. (1992) Lung may have an endocrine function producing hepatocyte growth factor in response to injury of distal organs. Biochem. Biophys. Res. Commun., 182, 802-809.
35. Halaban, R., Rubin, J.S., Funasaka, Y., et al. (1992) Met and hepatocyte growth factor/scatter factor signal transduction in normal melanocytes and melanoma cells. Oncogene, 7, 2195-2206.
36. Roberts, R.A., Soames, A.R., Gill, J.H., James, N.H. and Wheeldon, E.B. (1995) Non-genotoxic hepatocarcinogens stimulate DNA synthesis and their withdrawal induces apoptosis, but in different hepatocyte populations. Carcinogenesis, 16, 1693-1698.