Effect of physiological fluids on radical intensity of sodium ascorbate and sodium 5,6-benzylidene-L-ascorbate

Anticancer Research

Volumn 17, Issue 6 D, 1997, Pages 4457-4461

  Satoh, Kazue ^a   Ida, Yoshiteru ^a   Asano, Kazuhito ^a   Hisamitsu, Tadashi ^a   Inagaki, Masahiro ^a   Sho, Sadayuki ^a   Kochi, Mutsuyuki ^b   Tanaka, Tamotsu ^c   Sakagami, Hiroshi ^c  

^a SHOWA UNIVERSITY   (Japan)

^b Ichijokai Hospital   (Japan)

^c MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

Antitumor activity; Ascorbate; Benzylidene ascorbate; Blood; ESR; Homogenate; Radical; Saliva

Indexed keywords

5,6 BENZYLIDENEASCORBIC ACID; ANTINEOPLASTIC AGENT; ASCORBIC ACID; FREE RADICAL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD; BLOOD CELL; BODY FLUID; BRAIN HOMOGENATE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER HOMOGENATE; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; TARGET ORGAN;

ANIMALS; ANTINEOPLASTIC AGENTS; ASCORBIC ACID; BENZYLIDENE COMPOUNDS; BRAIN; DOGS; FREE RADICALS; GUINEA PIGS; HUMANS; LIVER; MICE; MICE, INBRED BALB C; RABBITS; RATS; RATS, INBRED F344; SALIVA;

EID: 0031427213     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Sakagami H, Satoh K, Ohata H, Takahashi H, Yoshida H, Iida M, Kuribayashi N, Sakagami T, Momose K and Takeda M: Relationship bewteen ascorbyl radical intensity and apoptosis-inducing activity. Anticancer Res 16: 2635-2644, 1996.
2. Satoh K, Ida Y, Kochi M, Tajima M, Kashimata M and Sakagami H: Effect of metals and antagonists on radical intensity and cytotoxicity of ascorbates. Anticancer Res 17: in press, 1997.
3. Satoh K, Ida Y, Kimura S, Taguchi K, Numaguchi M, Gomi K, Kochi M and Sakagami H: Chelating effect of human serum proteins on metal-catalyzed ascorbate radical generation. Anticancer Res 17: in press 1997.
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7. Satoh K, Ao Y, Asano K and Sakagami H: Rapid determination of ascorbate by ESR spectroscopy. Anticancer Res 17: in press, 1997.
8. Iriyama K, Yoshiyra M, Iwamoto Y and Ozaki Y: Simultaneous determination of uric and ascorbic acids in human serum by reverse-phase high-performance liquid chromatography with electrochemical detection. Anal Biochem 141: 238-242, 1984.
9. Sakagami H, Sakagami T, Takeda M, Iwaki K and Takeda K: Determination of sodium 5,6-benzylidene-L-ascorbate and related compounds by high-performance liquid chromatography. J Chromatogr A 653: 37-43, 1993.
10. Sakagami H, Sakagami T, Yamamura M, Takahashi H, Shibuya I and Takeda M: Stability of sodium 5,6-benzylidene-L-ascorbate. Anticancer Res 15: 1269-1274, 1995.
11. Sakagami H, Asano K, Fukuchi K, Gomi K, Ota H, Kazama K, Tanuma S and Kochi M: Induction of tumor degeneration by sodium benzylidene ascorbate. Anticancer Res 11: 1533-1538, 1991.