Schizophrenia genetics at the millennium: Cautious optimism

Clinical Genetics

Volumn 52, Issue 5, 1997, Pages 404-407

  Gottesman, Irving I ^a   Moldin, Steven O ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Epigenetic; Linkage; Multifactorial disease; QTL; Susceptibility genes

Indexed keywords

CHROMOSOME 20P; CHROMOSOME 22Q; CHROMOSOME 3P; CHROMOSOME 5Q; CHROMOSOME 6P; CHROMOSOME 8P; CHROMOSOME 9P; CLINICAL GENETICS; CONFERENCE PAPER; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE PREDISPOSITION; ENVIRONMENTAL FACTOR; EXPERIMENTAL MODEL; GENE REPLICATION; GENETIC EPIDEMIOLOGY; HUMAN; MOLECULAR GENETICS; PHENOTYPE; PRIORITY JOURNAL; SCHIZOPHRENIA;

EID: 0031426346     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0004.1997.tb04361.x     Document Type: Conference Paper

References (32)

1. Antonarakis SE, Blouin JL, Pulver AE, Wolyniec P, Lasseter VK, Nestadt G, Kasch L, Babb R, Kazazian HH, Dombroski B. Schizophrenia susceptibility and chromosome 6p24-22. Nat Genet 1995: 11: 235-236.
2. DiLalla DL, Carey G, Gottesman II, Bouchard TJ. Heritability of MMPI personality indicators of psychopathology in twins reared apart. J Abnorm Psychol 1996: 105: 491-499.
3. Gottesman II. Schizophrenia epigenesis: past, present, and future. Acta Psychiatr Scand Suppl 1994: 384: 26-33.
4. Gottesman II. Schizophrenia genesis: the origins of madness. New York: WH Freeman & Company, 1991.
5. Gottesman II, Bertelsen A. Confirming unexpressed genotypes for schizophrenia: risks in the offspring of Fischer's Danish identical and fraternal discordant twins. Arch Gen Psychiatry 1989: 46: 867-872.
6. Kendler KS, Diehl SR. Schizophrenia: genetics. In: Kaplan HI, Sadock BJ eds. Comprehensive textbook of psychiatry, VI, 6th edn. Baltimore, MD: Williams & Wilkins, 1995: 942-957.
7. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995: 11: 241-247.
8. McGue M, Gottesman II. Genetic linkage in schizophrenia: perspectives from genetic epidemiology. Schizophr Bull 1989: 15: 453-464.
9. McGuffin P, Sargeant M, Hetti G, Tidmarsh S, Whatley S, Marchbanks RM. Exclusion of a schizophrenia susceptibility gene from the chromosome 5q11-q13 region. New data and a reanalysis of previous reports. Am J Hum Genet 1990: 47: 524-535.
10. Moises HW, Yang L, Kristbjarnarson H, Wiese C, Byerley W, Macciardi F, Arolt V, Blackwood D, Liu X, Sjogren B, Aschauer HN, Hwu H-G, Jang K, Livesley WJ, Kennedy JL, Zoega T, Ivarsson O, Bui M-T, Yu M-H, Havsteen B, Commenges D, Weissenbach J, Schwinger E, Gottesman II, Pakstis AJ, Wetterberg L, Kidd KK, Helgason T. An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet 1995: 11: 321-324.
11. Moldin SO. Indicators of liability to schizophrenia: perspectives from genetic epidemiology. Schizophr Bull 1994: 20: 169-184.
12. Moldin SO, Gottesman II. Genes, experience, and chance in schizophrenia: positioning for the 21st century. Schizophr Bull 1997: 23: 547-561.
13. Moldin SO, Gottesman II, Erlenmeyer-Kimling L, Cornblatt BA. Psychometric deviance in offspring at risk for schizophrenia: 1. Initial delineation of a distinct subgroup. Psychiatry Res 1990a: 32: 297-310.
14. Moldin SO, Rice JP, van Eerdewegh P, Gottesman II, Erlenmeyer-Kimling L. Estimation of disease risk under bivariate models of multifactorial inheritance. Genet Epidemiol 1990b: 7: 371-386.
15. Peltonen P. Schizophrenia - all out for chromosome six. Nature 1995: 378: 665-666.
16. Portin P, Alanen YO. A critical review of genetic studies of schizophrenia. I. Epidemiological and brain studies. Acta Psychiatr Scand 1997a: 95: 1-5.
17. Portin P, Alanen YO. A critical review of genetic studies of schizophrenia. II. Molecular genetic studies. Acta Psychiatr Scand 1997b: 95: 73-80.
18. Pulver AE, Lasseter VK, Kasch L, Wolyniec P, Nestadt G, Blouin JL, Kimberland M, Babb R, Vourlis S, Chen H. Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am J Med Genet 1995: 60: 252-260.
19. Risch NJ. Linkage strategies for genetically complex traits: I. Multilocus models. Am J Hum Genet 1990: 46: 222-228.
20. Risch NJ, Merikangas K. The future of genetic studies of complex human diseases. Science 1996: 273: 1516-1517.
21. Rothenberg K, Fuller B, Rothstein M, Duster T, Kahn MJE, Cunningham R, Fine B, Hudson K, King M-C, Murphy P, Swergold G, Collins F. Genetic information and the workplace: legislative approaches and policy challenges. Science 1997: 275: 1755-1757.
22. Schizophrenia Linkage Collaborative Group for Chromosomes 3, 6 and 8. Additional support for schizophrenia linkage on chromosomes 6 and 8: a multicenter study. Am J Med Genet 1996: 67: 580-594.
23. Schwab SG, Albus M, Hallmayer J, Honig S, Borrmann M, Lichtermann D, Ebstein RP, Ackenheil M, Lerer B, Risch N. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nat Genet 1995: 11: 325-327.
24. Sherrington R, Brynjolfsson J, Petursson H, Potter M, Dudleston K, Barraclough B, Wasmuth J, Dobbs M, Gurling HMD. Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 1988: 336: 164-167.
25. Sing CF, Haviland MB, Reilly SL. Genetic architecture of common multifactorial diseases. In: Ciba Foundation Symposium 197. Variation in the human genome. Chichester, UK: Wiley and Sons, 1996: 211-232.
26. Sing CF, Zerba KE, Reilly SL. Traversing the biological complexity in the hierarchy between genome and CAD endpoints in the population at large. Clin Genet 1994: 46: 6-14.
27. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993: 52: 506-516.
28. Straub RE, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Webb BT, Zhang J, Walsh D, Kendler KS. A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nat Genet 1995: 11: 287-293.
29. Strohman RC. The coming Kuhnian revolution in biology. Nature Biotechnology 1997: 15: 194-200.
30. Wang S, Sun CE, Walczak CA, Ziegle JS, Kipps BR, Goldin LR, Diehl SR. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nat Genet 1995: 10: 41-46.
31. Woolf C. Does the genotype for schizophrenia often remain unexpressed because of canalization and stochastic events during development? Psychol Med 1997: 27: 659-668.
32. Wyatt RJ, Henter I, Leary MC, Taylor E. An economic evaluation of schizophrenia - 1991. Soc Psychiatry Psychiatr Epidemiol 1995: 30: 196-205.