2-chlorodeoxyadenosine administration to patients with the myeloid blast phase of chronic myelogenous leukemia

Leukemia and Lymphoma

Volumn 28, Issue 1-2, 1997, Pages 183-185

  Gollard, Russell ^a   Miller, William E ^a   Piro, Lawrence D ^a   Saven, Alan ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

2 chlorodeoxyadenosine; Blast phase CML

Indexed keywords

ANAGRELIDE; CLADRIBINE; HYDROXYUREA; INTERFERON;

ADULT; AGED; ANEMIA; ARTICLE; BLAST CELL; CANCER SURVIVAL; CASE REPORT; CHRONIC MYELOID LEUKEMIA; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE COUNT; LEUKOCYTOSIS; MALE; PRIORITY JOURNAL; SPLENOMEGALY; THROMBOCYTOPENIA;

EID: 0031425934     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199709058345     Document Type: Article

References (7)

1. Saven, A. and Piro, L. D. (1994). 2-Chlorodeoxyadenosine: A newer purine analogue active in the treatment of indolent lym-phoid malignancies. Annals of Internal Medicine, 120, 784-791.
2. Saven, A., Piro, L. D., Lemon, R. H., Figueroa, M. L., Kosty, M., Ellison, D. J. and Beutler, E. (1994). Complete hematologic remissions in chronic-phase, Philadelphia-chromosome-positive, chronic myelogenous leukemia after 2-chlorodeoxy-adenosine. Cancer, 73, 2953-2963.
3. Santana, V. M., Mirro, J., Jr., Harwood, F. C., Cherrie, J., Schell, M., Kalwinsky, D. and Blakley, R. L. (1991). A phase I clinical trial of 2-chlorodeoxyadenosine in pediatric patients with acute leukemia. Journal of Clinical Oncology, 9, 416-422.
4. Santana, V. M., Mirro, J., Jr., Kearns, C., Schell, M. J., Crom, W. and Blakley, R. L. (1992). 2-Chlorodeoxyadenosine produces a high rate of complete hematologic remission in relapsed acute myeloid leukemia. Journal of Clinical Oncology, 10, 364-370.
5. Saven, A., Cheung, W. K., Smith, I., Moyer, M., Johannsen, T., Rose, E., Gollard, R., Kosty, M., Miller, W. E. and Piro, L. D. (1996). Pharmacokinetic study of oral and bolus intravenous 2-chlorodeoxyadenosine in patients with malignancy. Journal of Clinical Oncology, 14, 978-983.
6. Petzer, A. L., Bilgeri, R., Zilian, U., Haun, M., Geisen, F. H., Pragnell, I., Braunsteiner, H. and Konwalinka, G. (1991). Inhibitory effect of 2-chlorodeoxyadenosine on granulocytic, erythroid, and T-lymphocytic colony growth. Blood. 78, 2583-2587.
7. Petzer,. A. L., Bilgen, R., Geisen, F. H., Zilian, U., Haun, M., Braunsteiner, H. and Konwalinka, G. (1991). Inhibitory activity of 2-chlorodeoxyadenosine and antagonization by deoxycytidine. In Investigations on Human Normal and Chronic Myelogenous Leukemia Hematopoietic Progenitor Cells (CFU-GM, BFU-E and CFU-E). Second International Symposium on the Molecular Biology of Hematopoiens, Innsbrook, Austria. July, edited by G. Konwalinka and N. G. Abraham, 1992.