(-)-Nornicotine partially substitutes for (+)-amphetamine in a drug discrimination paradigm in rats

Pharmacology Biochemistry and Behavior

Volumn 58, Issue 4, 1997, Pages 1083-1087

  Bardo, M T ^a   Bevins, R A ^a   Klebaur, J E ^a   Crooks, P A ^b   Dwoskin, L P ^b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b University of Kentucky   (United States)

Author keywords

Amphetamine; Discrimination stimulus; Drug cue; Drug discrimination; Nicotine; Nornicotine; Rat

Indexed keywords

AMPHETAMINE; NICOTINE; NORNICOTINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DOSE RESPONSE; DRUG DISCRIMINATION; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; SENSITIZATION;

ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; CONDITIONING, OPERANT; CUES; DEXTROAMPHETAMINE; DISCRIMINATION (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NICOTINE; NICOTINIC AGONISTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031425153     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(97)00303-1     Document Type: Article

References (34)

1. Barrett R. J., Caul W. F., Huffman E. M., Smith R. L. Drug discrimination is a continuous rather than a quantal process following training on a VI-TO schedule of reinforcement. Psychopharmacology (Berlin). 113:1994;289-296.
2. Bowman E. R., Turnbull L. B., McKennis H Metabolism of nicotine in the human and excretion of pyridine compounds by smokers. J. Pharmacol. Exp. Ther. 127:1959;91-102.
3. 2 mediation of the discriminative stimulus properties of d-amphetamine and cocaine. Psychopharmacology (Berlin). 103:1991;50-55.
4. Chance W. T., Murfin D., Krynock G. M., Rosecrans J. A. A description of the nicotine stimulus and tests of its generalization to amphetamine. Psychopharmacology (Berlin). 55:1977;19-26.
5. Clarke P. B. S., Fu D. S., Jakubovic A., Fibiger H. C. Evidence that mesolimbic dopaminergic activation underlies the locomotor stimulant action of nicotine in rats. J. Pharmacol. Exp. Ther. 246:1988;701-708.
6. Corrigall W. A., Coen K. M. Dopamine mechanisms play at best a small role in the nicotine discriminative stimulus. Pharmacol. Biochem. Behav. 48:1994;817-820.
7. Corrigall W. A., Coen K. M., Adamson K. L. Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area. Brain Res. 653:1994;278-284.
8. Corrigall W. A., Franklin K. B. J., Coen K. M., Clarke P. B. S. The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine. Psychopharmacology (Berlin). 107:1992;285-289.
9. Crooks P. A., Li M., Dwoskin L. P. Determination of nicotine metabolites in rat brain after peripheral radiolabeled nicotine administration. Detection of nornicotine Drug Metab. Dispos. 23:1995;1175-1177.
10. Di Chiara G., Imperato A. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc. Natl. Acad. Sci. USA. 85:1988;5274-5278.
11. 3H]nicotine binding in rat whole brain NIDA Res. Monogr. 162:1995;311.
12. 1-antagonists in animals trained to discriminate d-amphetamine or pentobarbital. J. Pharmacol. Exp. Ther. 250:1989;779-787.
13. Fowler S. C., Johnson J. S., Kallman M. J., Liou J. R., Wilson M. C., Hikal A. H. In a drug discrimination procedure isolation-reared rats generalized to lower doses of cocaine and amphetamine than rats reared in an enriched environment. Psychopharmacology (Berlin). 110:1993;115-118.
14. Goldberg S. R., Risner M. E., Stolerman I. P., Reavill C., Garcha H. S. Nicotine and some related compounds. Effects on schedule-controlled behavior and discriminative properties in rats Psychopharmacology (Berlin). 97:1989;295-302.
15. Hirschhorn I. D., Rosecrans J. A. Studies on the time course and the effect of cholinergic and adrenergic receptor blockers on the stimulus effect of nicotine. Psychopharmacologia. 40:1974;109-120.
16. Ho B. T., Huang J. T. Role of dopamine in d-amphetamine-induced discriminative responding. Pharmacol. Biochem. Behav. 3:1975;1085-1092.
17. Leikola-Pelho T., Jackson D. M. Preferential stimulation of locomotor activity by ventral tegmental microinjections of (-)-nicotine. Pharmacol. Toxicol. 70:1992;50-52.
18. Nielsen E. B., Scheel-Kruger J. Cuing effects of amphetamine and LSD. Elicitation by direct microinjections of the drugs into the nucleus accumbens Eur. J. Pharmacol. 125:1986;85-92.
19. Nisell M., Nomikos G. G., Svensson T. H. Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area. Synapse. 16:1994;36-44.
20. Pontieri F. E., Tanda G., Orzi F., Di Chiara G. Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature. 382:1996;255-257.
21. Reavill C., Stolerman I.P. Interaction of nicotine with dopaminergic mechanisms assessed through drug discrimination and rotational behavior in rats. J. Pharmacol. 1:1987;264-273.
22. Reavill C., Stolerman I. P. Locomotor activity in rats after administration of nicotinic agonists intracerebrally. Br. J. Pharmacol. 99:1990;273-278.
23. Risner M. E., Cone E. J., Benowitz N. L., Jacob P. J. Effects of stereoisomers of nicotine and nornicotine on schedule controlled responding and physiological parameters of dogs. J. Pharmacol. Exp. Ther. 244:1988;807-813.
24. Risner M. E., Goldberg S. R., Prada J. A., Cone E. J. Effects of nicotine, cocaine and some of their metabolites on schedule controlled responding by beagle dogs and squirrel monkeys. J. Pharmacol. Exp. Ther. 234:1985;113-119.
25. Schechter M., Meehan S. M. Dopaminergic mediation of the stimulant generalization of nicotine. Prog. Neuropsychopharmacol. Biol. Psychiatry. 17:1993;835-845.
26. Shoaib M., Stolerman I. P. Brain sites mediating the discriminative stimulus effects of nicotine in rats. Behav. Brain Res. 78:1996;183-188.
27. Singer G., Wallace M., Hall R. Effects of dopaminergic nucleus accumbens lesions on the acquisition of schedule-induced self-injection of nicotine in the rat. Pharmacol. Biochem. Behav. 17:1982;579-581.
28. Stolerman I. P., Garcha H. S., Mizra N. R. Dissociations between the locomotor stimulant and depressant effects of nicotinic agonists in rats. Psychopharmacology (Berlin). 117:1995;430-437.
29. Stolerman I. P., Garcha H. S., Pratt J. A., Kumer R. Role of training dose in discrimination of nicotine and related compounds by rats. Psychopharmacology (Berlin). 84:1984;413-419.
30. Stolerman I. P., Pratt J. A., Garcha H. S., Giardini V., Kumar R. Nicotine cue in rats analysed with drugs acting on cholinergic and 5-hydroxytryptamine mechanisms. Neuropharmacology. 22:1983;1029-1037.
31. West W. B., Van Groll B. J., Appel J. B. Stimulus effects of d-amphetamine II. DA, NE, and 5-HT mechanisms Pharmacol. Biochem. Behav. 51:1995;69-76.
32. Whiteaker P., Garcha H. S., Wonnacott S., Stolerman I. P. Locomotor activation and dopamine release produced by nicotine and isoarecolone in rats. Br. J. Pharmacol. 116:1995;2097-2105.
33. Woods J. H., Bertalmio A. J., Young A. M., Essman W. D., Winger G. Receptor mechanisms of opioid drug discrimination. Colpaert F. C., Balster R. L. Transduction mechanisms of drug stimuli. 1988;95-106 Springer Verlag, New York.
34. Zhang Y., Jacob P., Benowitz N. D. Determination of nornicotine in smokers' urine by gas chromatography following reductive alkylation to N·-propylnornicotine. J. Chromatog. 525:1990;349-357.