Estimating the distribution of synaptic reliabilities

Journal of Neurophysiology

Volumn 78, Issue 6, 1997, Pages 2870-2880

  Huang, Emily P ^a   Stevens, Charles F ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL TISSUE; ARTICLE; EXCITATORY POSTSYNAPTIC POTENTIAL; EXOCYTOSIS; HIPPOCAMPUS; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROBABILITY; RAT; SYNAPTIC TRANSMISSION;

EID: 0031425145     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1997.78.6.2870     Document Type: Article

References (29)

1. ALLEN, C. AND STEVENS, C. F. An evaluation of causes for unreliability of synaptic transmission. Proc. Natl. Acad. Sci. USA 91: 10380-10383, 1994.
2. BEKKERS, J. M. AND STEVENS, C. F. Presynaptic mechanism for long-term potentiation in the hippocampus. Nature 346: 724-729, 1990.
3. BEKKERS, J. M. AND STEVENS, C. F. Cable properties of cultured hippocampal neurons determined from sucrose-evoked miniature EPSCs. J. Neurophysiol. 75: 1250-1255, 1996.
4. BOLSHAKOV, V. Y. AND SIEGELBAUM, S. A. Regulation of hippocampal transmitter release during development and long-term potentiation. Science 269: 1730-1734, 1995.
5. DOBRUNZ, L. E. AND STEVENS, C. F. Heterogeneity of release probability, facilitation, and depletion at central synapses. Neuron 18: 995-1008, 1997.
6. DODGE, F. A., JR. AND RAHAMIMOFF, R. Co-operative action of calcium ions in transmitter release at the neuromuscular junction. J. Physiol. (Lond.) 193: 419-432, 1967.
7. HESSLER, N. A., SHIRKE, A. M., AND MALINOW, R. The probability of transmitter release at a mammalian central synapse. Nature 366: 569-572, 1993.
8. HESTRIN, S., SAH, P., AND NICOLL, R. A. Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices. Neuron 5: 247-253, 1990.
9. HUETTNER, J. E. AND BEAN, B. P. Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc. Natl. Acad. Sci. USA 85: 1307-1311, 1988.
10. JACK, J. J., REDMAN, S. J., AND WONG, K. The components of synaptic potentials evoked in cat spinal motoneurones by impulses in single group la afferents. J. Neurophysiol. 321: 65-96, 1981.
11. JAHR, C. E. High probability opening of NMDA receptor channels by Lglutamate. Science 255: 470-472, 1992.
12. KATZ, B. The Release of Neural Transmitter Substances. Liverpool: Liverpool University Press, 1969.
13. KORN, H., FABER D. S., AND TRILLER A. Probabilistic determination of synaptic strength. J. Neurophysiol. 55: 402-421, 1986.
14. KULLMANN, D. M., ERDEMLI, G., AND ASZTELY, F. LTP of AMPA and NMDA receptor-mediated signals: evidence for presynaptic expression and extrasynaptic glutamate spill-over. Neuron 17: 461-474, 1996.
15. MAGLEBY, K. L. Short-term changes in synaptic efficacy. In: Synaptic Function, edited by G. M. Edelman, V. E. Gall, and K. M. Cowan. New York: John Wiley, 1987, p. 21-56.
16. MALINOW, R. AND TSIEN, R. W. Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices. Nature 346: 177-80, 1990.
17. MANABE, T. AND NICOLL, R. A. Long-term potentiation: evidence against an increase in transmitter release probability in the CA1 region of the hippocampus. Science 265: 1888-1892, 1994.
18. MANABE, T., WYLLIE, D. J., PERKEL D. J., AND NICOLL, R. A. Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus. J. Neurophysiol. 70: 1451-1459, 1993.
19. MURTHY, V. N., SEJNOWSKI, T. J., AND STEVENS, C. F. Heterogenous release properties of visualized individual hippocampal synapses. Neuron 18: 599-612, 1997.
20. RAASTAD, M. Extracellular activation of unitary excitatory synapses between hippocampal CA3 and CA1 pyramidal cells. Ear. J. Neurosci. 7: 1882-1888, 1995.
21. RAASTAD, M., STORM, J. F., AND ANDERSEN, P. Putative single quantum and single fibre excitatory postsynaptic currents show similar amplitude range and variability in rat hippocampal slices. Eur. J. Neurosci. 4: 113-117, 1992.
22. 3[H] MK801 binding to the NMDA receptor/ionophore complex is regulated by divalent cations: evidence for multiple regulatory sites. Eur. J. Pharm. 151: 103-112, 1988.
23. ROSENMUND, C., CLEMENTS, J. D., AND WESTBROOK, G. L. Nonuniform probability of glutamate release at a hippocampal synapse. Science 262: 754-757, 1993.
24. ROSENMUND, C., FELTZ, A., AND WESTBROOK, G. L. Synaptic NMDA receptor channels have a low open probability. J. Neurosci. 15: 2788-2795, 1995.
25. STEVENS, C. F. AND WANG, Y. Reversal of long-term potentiation by inhibitors of haem oxygenase. Nature 364: 147-149, 1993.
26. STEVENS, C. F. AND WANG, Y. Changes in reliability of synaptic function as a mechanism for plasticity. Nature 371: 704-707, 1994.
27. STEVENS, C. F. AND WANG, Y. Facilitation and depression at single central synapses. Neuron 14: 795-802, 1995.
28. WALMSLEY, B., EDWARDS, F. R., AND TRACEY, D. J. Nonuniform release probabilities underlie quantal synaptic transmission at a mammalian excitatory central synapse. J. Neurophysiol. 60: 889-900, 1988.
29. ZUCKER, R. S. Short-term synaptic plasticity. Annu. Rev. Neurosci. 12: 13-31, 1989.