Changed systemic and cerebral hemodynamics and oxygen supply due to gradual hemorrhagic hypotension induced by an external PID-controller in newborn swine

Experimental and Toxicologic Pathology

Volumn 49, Issue 6, 1997, Pages 469-476

  Bauer, Reinhard ^a   Hoyer, Dirk ^a   Walter, Bernd ^a   Gaser, Elke ^a   Kluge, Harald ^a   Zwiener, Ulrich ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Blood flow measurement; Brain hemodynamics; Cerebral hemodynamics; Hemodynamics, cerebral; Hemorrhagic, hypotension; Heodynamics, systemic; Hypotension, hemorrhagic; Microspheres, colored (CMS).; Newborn piglets, hemorrhagic hypotension; Oxygen supply; PID controller, external; Proportional integral differential (PID) controller

Indexed keywords

ADRENALIN; CATECHOLAMINE DERIVATIVE; MICROSPHERE; NORADRENALIN;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN REGION; CATECHOLAMINE BLOOD LEVEL; CONTROL SYSTEM; CONTROLLED STUDY; HEART OUTPUT; HEMODYNAMICS; HEMORRHAGIC HYPOTENSION; METABOLIC PARAMETERS; NEWBORN; NONHUMAN; OXYGEN SUPPLY; STEADY STATE; SWINE; SYSTEMIC CIRCULATION; TECHNIQUE; VASCULAR RESISTANCE;

ANIMALIA; SUS SCROFA;

EID: 0031424292     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(97)80139-X     Document Type: Article

References (19)

1. ASHWAL S, DALE SP, LONGO LD: Regional cerebral blood flow: Studies in the fetal lamb during hypoxia, hypercapnia, acidosis and hypotension. Pediatr Res 1984; 18: 1309-1316.
2. BAUER R, WALTER B, WÜRKER E, et al.: Coloured microsphere technique as a new method for quantitative-multiple estimation of regional hepatic and portal blood flow. Exp Toxic Pathol 1996; 48 (5): 415-420.
3. BUCKLEY BJ, GOOTMAN N, NAGELBERG JS, et al.: Cardiovascular responses to arterial and venous hemorrhage in neonatal swine. Am J Physiol 1984; 247: R626-R633.
4. BUCKLEY NM: Maturation of circulatory system in three mammalian models of human development. - MINI-REVIEW. Comp Biochem Physiol 1986; 83A: 1-7.
5. BUCKLEY NM, GOOTMAN PM, YELLIN EL, et al.: Age-related cardiovascular effects of catecholamines in anesthetized piglets. Circ Res 1979; 45: 282-292.
6. CORBETT RJ: In vivo multinuclear magnetic resonance spectroscopy investigations of cerebral development and metabolic encephalopathy using neonatal animal models. Semin Perinatol 1990; 14 (3): 258-271.
7. EDVINSSON L, MACKENZIE ET, MCCULLOCH J: Cerebral Blood Flow and Metabolism. Raven Press New York 1993.
8. HEYMANN MA, IWAMOTO HS, RUDOLPH AM: Factors affecting changes in the neonatal systemic circulation. Ann Rev Physiol 1981; 43: 371-383.
9. HILL A: Current Concepts of Hypoxic-ischemic Cerebral Injury in the Term Newborn. Pediatr Neurol 1991, 7: 317-325.
10. LAPTOOK AR, CORBETT RJT, NGYEN H, et al.: Alterations in cerebral blood flow and phosphorylated metabolites in piglets during and after partitial ischemia. Pediat Res 1988; 23: 206-211.
11. LAPTOOK AR, STONESTREET BS, OH W: Autoregulation of brain blood flow in the newborn piglet: Regional differences in flow reduction during hypotension. Early Hum Develop 1982; 6: 99.
12. 2 delivery during hemorrhagic hypotension in the piglet. Pediatr Res 1983; 17: 77-80.
13. LERMAN J, OYSTON JP, GALLAGHER TM, et al.: The minimum alveolar concentration (MAC) and hemodynamic effects of Halothane, Isoflurane, and Sevoflurane in newborn swine. Anesthesiology 1990; 73: 717-721.
14. LOU HC: Hypoxic-hemodynamic pathogenesis of brain lesions in the newborn. Brain Dev 1994; 16: 423-431.
15. MACKENZIE ET, STRANDGAARD S, GRAHAM DI, et al.: Effects of acutely induced hypertension in cats on pial arte-riolar caliber, local cerebral blood flow, and the blood-brain barrier. Circ Res 1976; 39: 33-41.
16. MAKOWSKI EL, MESCHIA G, DROEGEMUELLER W, et al.: Measurement of umbilical arterial blood flow up to the sheep placenta and fetus in utero. Circ Res 1968, 23: 623-631.
17. POWNALL R, DALTON RG: Blood and plasma volumes of neonatal pigs expressed relative to bodyweight and total body water. Br vet J 1973; 129: 583-588.
18. RUDOLPH AM, IWAMOTO HS: Neurohormonal regulation of the fetal circulation. In: MONSET-COUCHARD M, MINKOWSKI A (eds.): Physiological and biochemical basis for Perinatal Medicine. S. Karger, Basel 1981: 263-270.
19. TUOR UI, DEL BIGIO MR, CHUMAS PD: Brain damage deu to cerebral hypoxia/ischemia in the neonate. Pathology and pharmacological modification. Cerebrovasc Brain Metab Rev 1996; 604: 165-172.