Structural and functional investigations on the role of zinc in bifunctional rat peptidylglycine α-amidating enzyme

Biochemistry

Volumn 36, Issue 51, 1997, Pages 16239-16246

  Bell, Joseph ^a   Ash, David E ^a   Snyder, Lynn M ^b   Kulathila, Raviraj ^b,e   Blackburn, Ninian J ^c   Merkler, David J ^d  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Unigene Laboratories Incorporated   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d DUQUESNE UNIVERSITY   (United States)

^e Novartis Pharmaceutical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMIDATING ENZYME; ZINC;

ANIMAL CELL; ARTICLE; CHO CELL; DEALKYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; RAT; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; APOPROTEINS; CHO CELLS; COPPER; CRICETINAE; EDETIC ACID; KINETICS; MIXED FUNCTION OXYGENASES; MULTIENZYME COMPLEXES; OLIGOPEPTIDES; RATS; SPECTRUM ANALYSIS; X-RAYS; ZINC;

ANIMALIA;

EID: 0031424158     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi970903d     Document Type: Article

References (9)

1. Auld, D. S., & Holmquist, B. (1974) Biochemistry 13, 4355-4361.
2. Ben-Meir, D., Spungin, A., Ashkenazi, R., & Blumberg, S. (1993) Eur. J. Biochem. 212, 107-112.
3. Binsted, N., Gurman, S. J., & Campbell, J. W. (1988) EXCURV88 Program, Daresbury Laboratory, Warrington, U.K.
4. Blackburn, N. J., Hasnain, S. S., Pettingill, T. M., & Strange, R. W. (1991) J. Biol. Chem. 266, 23120-23127.
5. Bode, W., Gomis-Rüth, F. X., Huber, R., Zwilling, R., & Stöcker, W. (1992) Nature 358, 164-167.
6. Boswell, J. S., Reedy, B. J., Kulathila, R., Merkler, D., & Blackburn, N. J. (1996) Biochemistry 35, 12241-12250.
7. Bradbury, A. F., Finnie, M. D. A., Smyth, D. G. (1982) Nature 298, 686-688.
8. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
9. Brown, D. C., & Collins, K. D. (1991) J. Biol. Chem. 266, 1597-1604.