Interferon α reduces the level of radiation-induced micronuclei in mouse bone marrow cells

Archivum Immunologiae et Therapiae Experimentalis

Volumn 45, Issue 5-6, 1997, Pages 475-478

  Fomenko, Ludmila ^a   Sirota, Nicolai ^a   Ravin, Victor ^b   Gaziev, Azhub ^a  

^a INSTITUTE OF THEORETICAL AND EXPERIMENTAL BIOPHYSICS   (Russian Federation)

^b RUSSIAN ACADEMY OF SCIENCES   (Russian Federation)

Author keywords

irradiated mice; Antimutagenicity; In vivo; Interferon in liposomes; Micronuclei

Indexed keywords

ALPHA INTERFERON; ANTIMUTAGENIC AGENT; COBALT 60; LIPOSOME; PLACEBO;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; ENCAPSULATION; ERYTHROCYTE; GAMMA IRRADIATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; RADIATION INJURY; WHOLE BODY RADIATION;

ANIMALS; BONE MARROW CELLS; DRUG CARRIERS; GAMMA RAYS; INJECTIONS, INTRAPERITONEAL; INTERFERON-ALPHA; LIPOSOMES; MALE; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; RADIATION CHIMERA;

EID: 0031424083     PISSN: 0004069X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. ARMANT M., DELESPESSE G. and SARFATI M. (1995): IL-2 and IL-7 but not IL-12 protect natural killer cells from death by apoptosis and up-regulate bcl-2 expression. Immunology, 85, 331-337.
2. DAS K. C., LEWIS-MOLOCK Y. and WHITE C. W. (1995): Thiol modulation of TNF-α and IL-1 induced MnSOD gene expression and activation of NF-kB. Mol. Cell. Biochem., 148, 45-57.
3. FOMENKO L., KOZHANOWSKAJA J. and GAZIEV A. (1995): The adaptive repair response in tissue of chronically irradiated mice. Radiat. Protect Dosimetry, 62, 31-34.
4. FRIEDMAN R. L., MANLY S. P., MCMAHON M., KERR I. M. and STARK G. R. (1984): Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells. Cell, 38, 745-755.
5. KYLE G., WOOLEY P., KUMAR S. and MOSSAN K. (1985): Anti-proliferative effect of human recombinant interferon in combination with radiation and chemotherapeutic drugs in five human cell lines. Proc. Am. Assoc. Cancer Res., 26, 327-333.
6. LAMON E. W. PARRISH J., MARSHALL G., MEKISSACK R., WILLIAMS B., MELVIN J., JIANG X. L. and LI G. (1994): Synergistic induction of thermotolerance in murine natural killer cells by interferon α and mild heat shock. Radiat. Res., 139, 64-369.
7. MAVOURNIN K. H., BLAKEY D. H., CIMINO M. C., SALAMONE M. F. and HEDDLE J. A. (1990): The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the US Environmental Protection Agency Genetic Program. Mutat. Res., 239, 29-80.
8. NETA R. (1995): Cytokines as mediators of protection and injury from ionizing radiation. Radiat. Res., 141, 120.
9. NETA R., OPPENHEIM J. J., SCHREIBER R. D., CHIZZONITE R., LEDNEY G. D. and MACVITTIE T. J. (1991): Role of cytokines (interleukin 1, tumor necrosis factor, and transforming growth factor β) in natural and lipopolysaccharide-enhanced radioresistance. J. Exp. Med., 173, 1177-1182.
10. PATCHEN M., MACVITTIE T., WILLIAMS J., SCHWARTZ G. and SOUZA L. (1990): Administration of interleukin 6 stimulates multilineage hematopoiesis and accelerates recovery from radiation-induced hematopoietic depression. Blood, 77, 472-480.
11. RUTENFRANZ I., BAUER A. and KIRCHNER H. (1990): Interferon gamma encapsulated into liposomes enhances activity of monocytes and natural killer cells and has antiproliferative effects on tumor cells in vitro. Blut, 61, 30-37.
12. RUTENFRANZ I., BAUER A. and KIRCHNER H. (1990): Pharmacokinetic study of liposome-encapsulated human interferon gamma after intravenous and intramuscular injection in mice. J. Interferon Res., 10, 337-341.
13. SCHMID W. (1976): The micronucleus test for cytogenic analysis. In HOLLAENDER A.: Chemical mutagenes principales and methods for their detection. Plenum Press, New York, 31-53.
14. COLLAPUDI B. and KAMRA C. P. (1979): Application of a simple Giemsa-staining method in the micronucleus test. Mutat. Res., 64, 45-46.
15. SEKI H., IWAI K., KANEGANE H., KONNO A., OHTA K., OHTA K., YACHIE A., TANIGUCHI N. and MIYAWAKI T. (1995): Differential protective action of cytokines on radiation-induced apoptosis of peripheral lymphocyte subpopulations. Cell. Immunol., 163, 30-36.
16. SHUAI K. (1994): Interferon-activated signal transduction to the nucleus. Curr. Biol., 6, 253-259.
17. SIROTA N. P., BEZLEPKIN V. G., KUZNETSOVA E. A., LOMAEVA M. G., MILONOVA I. N., RAVIN V. K., GAZIEV A. I. and BRADBURY R. J. (1996): Modifying effect in vivo of interferon α on induction and repair of lesion in DNA of lymphoid cells of γ-irradiated mice. Radiat. Res., 146, 100-105.
18. WADLER S. and SCHWARTZ E. L. (1990): Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: a review. Cancer Res., 50, 3473-3486.
19. WANG P. L., CONG S. J., DONG X. J., CHEN Z. C. and MA C. P. (1991): A genetic study of human interferon alpha induced repair of DNA damage in hepatitis B patients. Mutat. Res., 262, 125-129.
20. WILLIAMS B. R. G. (1991): Transcriptional regulation of interferon-stimulated genes. Eur. J. Biochem., 200, 1-11.
21. WONG G. H. W. and GOEDDEL D. V. (1988): Induction of manganese superoxide dismutase by tumor necrosis factor: possible protective mechanism. Science, 242, 941-944.
22. ZASUKHINA G. D., MAKEDONOV G. P., SHVETSOVA T. P., CHEKOVA V. V., ANDRONOVA A. V. and ALEKHINA N. I. (1986): Interferons as modifiers of mutagenesis and repair processes. Zh. Obshch. Biol. (in Russian), 37, 42-51.