Molecular genetic events in the development and progression of ovarian cancer in humans

Molecular Medicine Today

Volumn 3, Issue 5, 1997, Pages 207-213

  Chuaqui, Rodrigo F ^a   Zhuang, Zhengping ^a   Merino, Maria J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER DIAGNOSIS; CANCER GENETICS; CANCER INVASION; CARCINOGENESIS; FAMILIAL CANCER; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; MOLECULAR GENETICS; OVARY CANCER; REVIEW; TUMOR SUPPRESSOR GENE;

BREAST NEOPLASMS; CHROMOSOME DELETION; CHROMOSOME MAPPING; DISEASE SUSCEPTIBILITY; FAMILY; FEMALE; GENES, TUMOR SUPPRESSOR; GROWTH SUBSTANCES; HUMANS; LINKAGE (GENETICS); OVARIAN NEOPLASMS; RECEPTORS, CELL SURFACE; RECEPTORS, GROWTH FACTOR;

EID: 0031424074     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-4310(97)01043-5     Document Type: Review

References (49)

1. Isola, J. et al. (1990) Steroid receptors and Ki-67 reactivity in ovarian cancer and in normal ovary: correlation with DNA flow cytometry, biochemical receptor assay, and patient survival, J. Pathol. 162, 295-301
2. Bell, D.A. (1994) Flow cytometry, in Blaustein 's Pathology of the Female Genital Trad (4th edn), (Kurman, R.J., ed.) pp. 1161-1171, Springer-Verlag
3. Bell, D.A. (1991) Ovarian surface epithelial-stromal tumors, Hum. Pathol. 22, 750-762
4. Bast, R.C., Jr et al. (1992) Malignant transformation of ovarian epithelium, J. Natl. Cancer Inst. 84, 556-558
5. Kacinscki, B. et al. (1992) Neu protein overexpression in benign, borderline, and malignant ovarian neoplasms, Gynecol. Oncol. 44, 245-253
6. Slamon, D.J. et al. (1989) Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer, Science 244, 707-712
7. Zheng, J.P. et al. (1991) Distinction of low grade from high grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3, 6, and 11 and HER-2/neu gene amplification, Cancer Res. 51, 4045-4051
8. Cho, R.C. et al. (1994) Molecular Biology, in Blaustein 's Pathology of the Female Genital Tract (4th edn). (Kurman. R.J., ed.), pp. 1173-1198, Springer-Verlag
9. Enomoto, T. et al. (1990) K-ras activation in neoplasmas of the human female reproductive tract, Cancer Res. 50, 6139-6145
10. Quinn, M.A. et al. (1988) Steroid receptors and ovarian tumors: variation within primary tumors and between primary tumors and metastases, Gynecol. Oncol. 31, 424-429
11. Iversen, O.E. et al. (1986) Steroid receptor content in human ovarian tumors: survival of patients with ovarian carcinoma related to steroid receptor content, Gynecol. Oncol. 23, 65-76
12. Al-Timimi, A. et al. (1985) An immunohistochemical study of the incidence and significance of sex steroid hormone binding sites in normal and neoplastic human ovarian tissues, Int. J. Gynecol. Pathol. 4, 24-41
13. Knudson, A.G. (1971) Mutation and cancer: statistical study of retinoblastoma, Proc. Natl. Acad. Sci. U. S. A. 68, 820-823
14. Kohler, M.F. et al. (1993) Mutation and overexpression of p53 in early-stage epithelial ovarian cancer, Obstet. Gynecol. 81, 643-650
15. Kupryjanczyk, J. et al. (1993) p53 gene mutations and protein accumulation in human ovarian cancer, Proc. Natl. Acad. Sci. U. S. A. 90, 4961-4965
16. Teneriello, M.G. et al. (1993) p53 and Ki-ras gene mutations in epithelial ovarian neoplasms, Cancer Res. 53, 5105-5108
17. Klemi, P.J. et al. (1994) Immunohistochemical detection of p53 protein in borderline and malignant serous ovarian tumors, Int. J. Gynecol. Pathol. 13, 228-233
18. Kupryjanczyk, J. et al. (1995) p53 gene analysis of ovarian borderline tumors and stage I carcinoma, Hum. Pathol. 26, 387-392
19. Eccles, D.M. et al. (1990) Allele losses on chromosome 17 in human epithelial ovarian carcinoma, Oncogene 5, 1599-1601
20. Lee, J.H. et al. (1990) Frequent loss of heterozygosity on chromosomes 6q, 11, and 17 in human ovarian carcinomas, Cancer Res. 50, 2724-2728
21. Russell , S.E. et al. (1990) Allele loss from chromosome 17 in ovarian cancer, Oncogene 5, 1581-1583
22. Sato, T. et al. (1991) Allelotype of human ovarian cancer, Cancer Res. 51, 5118-5122
23. Gallion, H. et al. (1992) Molecular genetic changes in human epithelial ovarian malignancies, Gynecol. Oncol. 47, 137-142
24. Cliby, W. et al. (1993) Human epithelial ovarian cancer allelotype, Cancer Res. 53, 2393-2398
25. Phillips, N. et al. (1994) Allelic loss on chromosome 17 in human ovarian cancer, Int. J. Cancer 54, 85-91
26. Weitzel, J.N. et al. (1994) Molecular genetic changes associated with ovarian cancer, Gynecol. Oncol. 55, 245-252
27. Pieretti, M. et al. (1995) Genetic alterations on chromosome 17 distinguish different types of epithelial ovarian tumors, Hum. Pathol. 26, 393-397
28. Cooke, I.E. et al. (1996) Allele loss on chromosome arm 6q and fine mapping of the region at 6q27 in epithelial ovarian cancer, Genes Chromosomes Cancer 15, 223-233
29. Phillips, N.J. et al. (1996) Allelic deletion on chromosome 17p13.3 in early ovarian cancer, Cancer Res. 56, 606-611
30. Schultz, D.C. et al. (1996) Identification of two candidate tumor suppressor genes on chromosome 17p13.3, Cancer Res. 56, 1997-2002
31. Bryan, E.J. et al. (1996) Localization of an ovarian cancer tumor suppressor gene to a 0.5-cM region between D22S284 and CYP2D, on chromosome 22q, Cancer Res. 56, 719-721
32. Miki, Y. et al. (1994) A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1, Science 266, 66-71
33. Rubin, S.C. et al. (1996) Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1, New Engl. J. Med. 335, 1413-1416
34. Hosking, L. et al. (1995) A somatic BRCA1 mutation in an ovarian tumor, Nat. Genet. 9, 343-344
35. Merajver, S.D. et al. (1995) Somatic mutations in the BRCA1 gene in sporadic ovarian tumors, Nat. Genet. 9, 439-443
36. Takahashi, H. et al. (1995) Mutations analysis of the BRCA1 gene in ovarian cancers, Cancer Res. 55, 2998-3002
37. Takahashi, H. et al. (1996) Mutations of the BRCA2 gene in ovarian carcinomas. Cancer Res. 56, 2738-2741
38. Foster, K.A. et al. (1996) Somatic and germline mutations of the BRCA2 gene in sporadic ovarian cancers, Cancer Res. 56, 3622-3625
39. Wolf, G.N. et al. (1996) Origins of heterogeneous ovarian carcinomas: a molecular cytogenetic analysis of histologically benign, low malignant potential, and fully malignant components, Am J. Pathol. 149, 511-520
40. Zheng, J.P. et al. (1995) Genetic disparity between morphologically benign cysts contiguous to ovarian carcinomas and solitary cystadenomas, J. Natl. Cancer Inst. 87, 1146-1153
41. Iwabuchi, H. et al. (1995) Genetic analysis of benign, low-grade, and high-grade ovarian tumors, Cancer Res. 55, 6172-6180
42. Tsao, S-W. et al. (1993) Molecular genetic evidence of a unifocal origin for human serous ovarian carcinomas, Gynecol. Oncol. 48, 5-10
43. Kupryjanczyk, J. et al. (1996) Ovarian, peritoneal, and endometrial serous carcinoma: clonal origin of multifocal disease, Mod. Pathol. 9, 166-173
44. Jacobs, I.J. et al. (1992) Clonal origin of epithelial ovarian carcinoma: analysis by loss of heterozygosity, p53 mutation, and X-chromosome inactivation, J. Natl. Cancer Inst. 84, 1793-1798
45. Mok, C-H. et al. (1992) Unifocal origin of advanced human epithelial ovarian cancers, Cancer Res. 52, 5119-5122
46. Muto, M.G. et al. (1995) Evidence for a multifocal origin of papillary serous carcinoma of the peritoneum, Cancer Res. 55, 490-492
47. Zhuang, Z. et al. (1996) Barrett's esophagus: metaplastic cells with loss of heterozygosity at the APC gene locus are clonal precursors to invasive adenocarcinoma, Cancer Res. 56, 1961-1964
48. Chuaqui, R.F. et al. (1996) Genetic analysis of synchronous tumors of the ovary and appendix, Hum. Pathol. 27, 165-171
49. Emmert-Buck, M.R. et al. (1997) Molecular analysis of concomitant uterine and ovarian endometrioid tumors, Int. J. Gynecol. Pathol. 16, 143-148