Cerebral metabolic alterations in human immunodeficiency virus-related encephalopathy detected by proton magnetic resonance spectroscopy: Comparison between sequences using short and long echo times

Investigative Radiology

Volumn 32, Issue 8, 1997, Pages 485-495

  Salvan, Anne Marie ^a   Vion Dury, Jean ^a   Confort Gouny, Sylviane ^a   Nicoll, François ^a   Lamoureux, Sylvie ^a   Cozzone, Patrick J ^a  

^a University of Aix Marseille   (France)

Author keywords

Echo times, short and long; Encephalopathy, human immunodeficiency virus related; Glial activation; Neuronal injury; Proton magnetic resonance spectroscopy

Indexed keywords

CHOLINE; CREATINE; CREATINE PHOSPHATE; INOSITOL; N ACETYLASPARTIC ACID;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGED; ARTICLE; BRAIN ATROPHY; BRAIN DISEASE; BRAIN METABOLISM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0031423375     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004424-199708000-00008     Document Type: Article

References (60)

1. Ross B, Kreis R, Ernst T. Clinical tools for the 90s: Magnetic resonance spectroscopy and metabolite imaging. Eur J Radiol 1992;14:128-140.
2. Vion-Dury J, Meyerhoff DJ, Cozzone PJ, Weiner MW. What might be the impact on neurology of the analysis of brain metabolism by in vivo magnetic resonance spectroscopy? J Neurol 1994; 241: 354-371.
3. Menon DK, Ainsworth JG, Cox IJ, et al. Proton MR spectroscopy of the brain in AIDS dementia complex. J Comput Assist Tomogr 1992;16:538-542.
4. Chong WK, Sweeney B, Wilkinson ID, et al. Proton spectroscopy of the brain in HIV infection: Correlation with clinical, immunologic, and MR imaging findings. Radiology 1993; 188:119-124.
5. 1H magnetic resonance spectroscopic imaging. Neurology 1993;43:509-515.
6. Jarvik JG, Lenkinski RE, Grossman RI, Gomori JM, Schnall MD, Frank I. Proton MR spectroscopy of HIV-infected patients: Characterization of abnormalities with imaging and clinical correlation. Radiology 1993;186:739-744.
7. Vion-Dury J, Confort-Gouny S, Nicoli F, et al. Localized brain proton MRS metabolic patterns in HIV-related encephalopathies. CR Acad Sci (Paris) 1994;317:833-840.
8. Wiley CA, Achim CL. Human immunodeficiency virus encephalitis and dementia. Ann Neurol 1995;38:559-560.
9. Paley M, Cozzone PJ, Alonso J, et al. A multicenter proton magnetic resonance spectroscopy study of neurological complications of AIDS. AIDS Res Human Retrovir 1996;12:213-222.
10. McArthur JC. HIV dementia: 10 years on. J Neuro Virol 1996;2:8.
11. Chong WK. MR spectroscopy in HIV infection. Presented at the 3rd Annual Meeting of the Society of Magnetic Resonance in Medicine; August 19-25, 1995; Nice, France. Abstract 2.
12. Vion-Dury J, Nicoli F, Salvan AM, Confort-Gouny S, Dhiver C, Cozzone PJ. Reversal metabolic alterations with zidovudine detected by proton localised magnetic resonance spectroscopy. Lancet 1995; 345:60-61.
13. McConnell JR, Swindells S, Ong CS, et al. Prospective utility of cerebral proton magnetic resonance spectroscopy in monitoring HIV infection and its associated neurological impairment. AIDS Res Human Retovir 1994;10:977-982.
14. Laubenberger J, Häussinger D, Bayer S, et al. HIV-related metabolic abnormalities in the brain: Depiction with proton MR spectroscopy with short echo times. Radiology 1996; 199:805-810.
15. Paley M, Wilkinson ID, Hall-Craggs MA, Chong WK, Chinn RJS, Harisson MJG. Short echo time proton spectroscopy of the brain in HIV infection/AIDS. Magn Reson Imag 1995;13:871-875.
16. Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hänicke W, Sauter R. Localized high-resolution proton NMR spectroscopy using stimulated echoes: Initial application to human brain in vivo. Magn Reson Med 1989;9:79-93.
17. Confort-Gouny S, Vion-Dury J, Nicoli F, et al. A multiparametric data analysis showing the potential of localized proton MR spectroscopy of the brain in the metabolic characterization of neurological diseases. J Neurol Sci 1993; 118:123-133.
18. Chabrol B, Salvan AM, Confort-Gouny S, Vion-Dury J, Cozzone PJ. Localized proton magnetic resonance spectroscopy differentiates the inborn metabolic encephalopathies in children. CR Acad Sci (Paris) 1995;318:985-992.
19. Chang L, Miller BL, McBride D, et al. Brain lesions in patients with AIDS: H-1 MR spectroscopy. Radiology 1995;197:525- 531.
20. Working Group of the Academy of Neurology AIDS Task Force. Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus type 1 (HIV-1) infection. Neurology 1991;41:778-785.
21. Hahn FJ, Rim K. Frontal ventricular dimensions on normal CT. AJR Am J Roentgen 1976;126:593-596.
22. Aylward EH, Schwartz J, Machlin S, Pearlson G. Bicaudate ratio as a measure of caudate volume in MRI. Am J Neuroradiol 1991;12:1217-1222.
23. Michaelis T, Merboldt KD, Hänicke W, Gyngell ML, Brunn H, Frahm J. On the identification of cerebral metabolites in localized H-1 NMR spectra of human brain in vivo. NMR Biomed 1991;4:90-98.
24. Michaelis T, Helms G, Merboldt KD, Hänicke W, Bruhn H, Frahm J. Identification of scyllo-inositol in proton NMR spectra of human brain in vivo. NMR Biomed 1993;6:105-109.
25. Alger JR, Symko SC, Bizzi A, Posse S, DesPres D, Armstrong MR. Absolute quantitation of short TE brain 1-H MR spectra and spectroscopic imaging data. J Comput Assist Tomogr 1993; 17:191-199.
26. Tukey JW. Exploratory data analysis. Reading, MA: Addison-Wesley, 1977.
27. Cleveland S, McGill R. Graphical perception and graphical methods for analyzing scientific data. Science 1983;229:828-833.
28. Chong WK, Paley M, Wilkinson ID, et al. Localized cerebral proton MR spectroscopy in HIV infection and AIDS. Am J Neuroradiol 1994;15:21-25.
29. Nadler JV, Cooper JR. N-acetyl-L-aspartic acid content of human neural tumours and bovine peripheral nervous tissues. J Neurochem 1972;19:313-319.
30. Wilkinson ID, Paley M, Chong WK, et al. Proton spectroscopy in HIV infection: Relaxation times of cerebral metabolites. Magn Reson Imag 1994;12:951-957.
31. Blakely RD, Coyle JT. The neurobioloey of N-acetylaspartylglutamate. Int Rev Neurobiol 1988; 30:39-100.
32. Broderick DF, Wippold FJ, Clifford BD, Kido D, Wilson BS. White matter lesions and cerebral atrophy on MR images in patients with and without AIDS dementia complex. AJR Am J Roentgen 1993;161:177-181.
33. 1H MRSI in cognilively impaired HIV-seropositive individuals. Magn Reson Imag 1994;12:653-659.
34. Barker PB, Lee RR, McArthur J. AIDS dementia complex: Evaluation with proton MR spectroscopic imaging. Radiology 1995; 195:58-64.
35. Isacson O. On neuronal health. Trends Neurosci 1993;16:306-308.
36. Flögel U, Niendorf T, Serkowa N, Brand A, Henke J, Leibfritz D. Changes in organic solutes, volume, energy state, and metabolism associated with osmotic stress in a glial cell line: A multinuclear NMR study. Neurochem Res 1995;20:793-802.
37. Everall IP, Luthert PJ, Lantos PL. Neuronal loss in the frontal cortex in HIV infection. Lancet 1991;337:1119-1121.
38. Seilhean D, Duyckaerts C, Vazeux R, et al. HIV-1-associated cognitive/motor complex: Absence of neuronal loss in the cerebral cortex. Neurology 1993;43:1492-1499.
39. Petito CK, Roberts B. Evidence of apoptotic cell death in HIV encephalitis. Am J Pathol 1995; 146:1121-1130.
40. Dal Pan GJ, McArthur JH, Aylward E, et al. Patterns of cerebral atrophy in HIV-1-infected individuals: Results of a quantitative MRI analysis. Neurology 1992;42:2125-2130.
41. Aylward EH, Henderer JD, McArthur JC, et al. Reduced basal ganglia volume in HIV-1-associated dementia: Results from quantitative neuroimaging. Neurology 1993;43:2099-2104.
42. Brand A, Richter-Landsberg C, Leibfritz D. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 1993;15:289-298.
43. Videen JS, Michaelis T, Pinto P, Ross BD. Human cerebral osmolytes during chronic hyponatremia: A proton magnetic resonance spectroscopy study. J Clin Invest 1995;95:788-793.
44. Miller BL, Moats RA, Shonk T, Ernst T, Woolley S, Ross BD. Alzheimer disease: Depiction of increased cerebral myo-inositol with proton MR spectroscopy. Radiology 1993;187:433-437.
45. Shonk T, Ross BD. Role of increased cerebral myo-inositol in the dementia of Down syndrome Magn Reson Med 1995;33:858-861.
46. Gray F, Lescs MC. HIV-related demyelinating disease. Eur J Med 1993;2:89-96.
47. Epstein LG, Gendelman HE. Human immunodeficiency virus type 1 infection of the nervous system: Pathogenetic mechanisms. Ann Neurol 1993;33:429-436.
48. Wilt SG, Milward E, Zhou JM, et al. In vitro evidence for a dual role of tumor necrosis factor-a in human immunodeficiency virus type 1 encephalopathy. Ann Neurol 1995;37:381-394.
49. Price RW, Brew B, Sidtis J, Rosenblum M, Scheck A, Clearly P. The brain in AIDS: Central nervous system HIV-1 infection and AIDS dementia complex. Science 1988;239:586-592.
50. Brew BJ. The clinical spectrum and pathogenesis of HIV encephalopathy, myelopathy, and peripheral neuropathy. Curr Opin Neurol 1994;7:209-216.
51. 1H NMR spectroscopy: N-acetyl-L-aspartate, creatine and choline. NMR Biomed 1991; 4:47-52.
52. Richards TD. Proton NMR in multiple sclerosis: Value in establishing diagnosis, monitoring progression, and evaluating therapy. AJR Am J Roentgen 1991;157:1073-1078.
53. Toft PB, Leth L, Lou HC, Pryds O, Henriksen O. Metabolite concentrations in the developing brain estimated with proton MR spectroscopy. J Magn Reson Imag 1994;4:467-680.
54. Preece NE, Baker D, Butter C, Gadian D, Urenjak J. Experimental allergic encephalomyelitis raises betaine levels in the spinal cord of strain 13 guinea-pigs. NMR Biomed. 1993;6:194-200.
55. Salvan AM, Vion-Dury J, Confort-Gouny S, Nicoli F, Lamoureux S, Cozzone PJ. Brain proton MR spectroscopy in HIV-spectroscopy: Identification of evolving metabolic patterns in relation to dementia and therapy. AIDS Res Human Retrovir 1997; 13(12):1055-1066.
56. Post JD, Berger JR, Duncan R, Quencer RM, Pall L, Winfield D. Asymptomatic and neurologically symptomatic HIV-seropositive subjects: Results of long-term MR imaging and clinical follow-up. Radiology 1993;188:727-733.
57. Villa G, Monteleone D, Mara C, et al. Neuropsychological abnormalities in AIDS and asymptomatic HIV seropositive patients. J Neurol Neurosurg Psychiatry 1993;56:878-884.
58. Wiley CA, Achim C. Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome. Ann Neurol 1994;36:673-676.
59. Brew BJ, Rosenblum M, Cronin K, Price R. AIDS dementia complex and HIV-1 brain infection: Clinical-virological correlations. Ann Neurol 1995;38:563-570.
60. Bruguières P, Combes C, Ricolfi F, et al. Imagerie des encéphalites du virus de l'immunodéficience humaine (VIH). J Neuroradiol 1995;22:163-168.