Loss of T-cell cytotoxic responses in the course of HIV-1 infection

Thymus

Volumn 24, Issue 4, 1997, Pages 203-219

  Zerhouni, Bouchra ^a,b   Sanhadji, Kamel ^a   Touraine, Jean Louis ^a  

^a EDOUARD HERRIOT HOSPITAL   (France)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

AIDS; Cytotoxic T lymphocyte; HIV 1 proteins

Indexed keywords

ANTIGEN P24; GAG PROTEIN; NEF PROTEIN; VIRUS ENVELOPE PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AIDS RELATED COMPLEX; ARTICLE; CELLULAR IMMUNODEFICIENCY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISEASE COURSE; HLA TYPING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; PRIORITY JOURNAL;

ACQUIRED IMMUNODEFICIENCY SYNDROME; CYTOTOXICITY, IMMUNOLOGIC; HIV-1; HUMANS; IMMUNOPHENOTYPING; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0031422403     PISSN: 01656090     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016995307023     Document Type: Article

References (44)

1. Zinkernagel RM, Doherty PC. H2 compatibility requirement for T-cell mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structure coded for in H-2K or H-2D. J Exp Med 1975; 141: 1427-1436.
2. Townsend ARM, Rothbard J, Gotch FM, Bahadur G, Wraith D, McMichael A. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 1986; 44: 959-968.
3. Walker BD, Chakrabarti S, Moss B, Paradis TJ, Flynn T, Durno AG, Blumberg MS, Kaplan JC, Hirsh MS, Schooley RT. HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature 1987; 328: 345-348.
4. Koup RA, Sullivan JL, Levine PH, Brettler D, Mahr A, Mazzara G, McKenzie S, Panicali D. Detection of major histocompatibility complex class I-restricted, HIV-specific cytotoxic T lymphocytes in the blood of infected hemophiliacs. Blood 1989; 73: 1909-1914.
5. Johnson RP, Trocha A, Yang L, Mazzara GP, Panicalli DL, Bachanan TM, Walker BD. HIV-1 gag specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes: Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells. J Immunol 1991; 146: 1512-1521.
6. Walker CM, Thomson-Honnebier GA, Hsueh FC, Erickson AL, Pan LZ, Levy JA. CD8+ T cells from HIV-1-infected individuals inhibit acute infection by human and primate immunodeficieny viruses. Cell Immunol 1991; 137: 420-428.
7. Gomez AM, Smail FM, Rosenthal KL. Inhibition of HIV replication by CD8+ T cells correlates with CD4 counts and clinical stage of disease. Clin Exp Imunol 1994; 97: 68-75.
8. Barré-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, Dauguet C, Axler-Blin F, Brun-Vezinet F, Rouzioux C, Rozenbaum W, Montagnier L. Isolation of a T lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 1983; 868: 871-875.
9. Levy JA, Hoffman AD, Kramer SM, Lendis JA, Shimabukuro JM, Oshiro JM. Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS. Science 1984; 225: 840-844.
10. Liberman J, Fabry JA, Kuo MC, Earl P, Moss B, Skolnik PR. Cytotoxic T lymphocytes from HIV-1 seropositive individuals recognize immunodominant epitope in gp 160 and reverse transcriptase. J Immmunol 1992; 148: 2738-2747.
11. Shepp DA, Daguillard F, Mann D, Quinnan GV. Human class I MHC-restricted cytotoxic T-lymphocytes specific for human immunodeficiency virus envelope antigens. AIDS 1988; 2: 113-117.
12. Johnson RP, Trocha PA, Buchanan TM, Walker BD. Identification of overlapping HLA class I-retricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: definition of minimum epitopes and analysis of the effects of sequence variation. J Exp Med 1992; 175: 961-971.
13. Koenig S, Earl P, Powell D, Pantaleo G, Merli S, Moss B, Fauci AS. Group-specific, MHC class 1 restricted cytotoxic responses to HIV-1 envelope proteins by cloned peripheral blood T cells from an HIV-1-infected individual. Proc Natl Acad Sci USA 1988; 85: 8638-8642.
14. Harrer T, Harrer E, Kalams SA, Barbosa P, Trocha A, Johnson RP, Elbeik T, Feinberg MB, Buchbinder SP, Walker BD. Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and the relation to in vivo viral quasispecies in a person with prolonged infection and low viral load. J Immunol 1996; 156: 2616-2623.
15. Nixon DF, Townsend ARM, Elvin JG, Rizza CR, Gallwey J, McMichael AJ. HIV-1 gag specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides. Nature 1988; 336: 484-487.
16. Koup RA, Pikora CA, Luzuriaga K, Brettler D, Day ES, Mazzara GP, Sullivan JL. Limiting dilution analysis of cytotoxic T lymphocytes to human immunodeficiency virus gag antigens in infected persons: in vitro quantitation of effector cell populations with p!7 and p24.J Exp Med 1991; 174: 1593-1600.
17. BuseyneF, Me Chesney M, Porrot F, KovarikS,Guy B, Rivière Y. Gag-specific cytotoxic T lymphocytes from human immunodeficiency virus type 1-infected individuals. Gag epitopes are clustered in three regions of the p24 gag protein. J Virol 1993; 67: 694-702.
18. Rinaldo C, Huang XL, Fan Z, Ding M, Beltz L, Logar A, Panicali D, Mazzara G, Liebmann J, Cottrill M, Gupta P. High levels of anti-human immunodeficiency virus type l (HIV-1 ) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors. J Virol 1995; 69: 5838-5842.
19. Culmann B, Gomard E, Kieny MP, Guy B, Dreyfus F, Saimot AG, Sereni D, Sicard D, Levy JP. An antigenic peptide of HIV-1 nef protein recognized by cytotoxic T lymphocytes of seropositive individuals in association with different HLA-B molecules. Eur J Immunol 1989; 19: 2383-2386.
20. Culmann B, Gomard E, Kieny MP, Guy B, Dreyfus F, Saimot AG, Sereni D, Sicard S, Levy JP. Six epitopes reacting with human cytotoxic CD8+ T-cells in the central region of the HIV-1 nef protein. J Immunol 1991; 146: 1560-1565.
21. Koenig S, Fuerst TR, Wood LV, Woods RM, Suzich JA, Jones GM, De La Cruz VF, Davey RT, Venkatesan S, Moo B, Biddison WE, Fauci AS. Mapping the fine specificity of a cytolytic T cell response to HIV-1 nef protein. J Immunol 1990; 145: 127-135.
22. Walker BD, Flexner C, Paradis TJ, Fuller TC, Hirsch MS, Schooley RT, Moss B. HIV1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals. Nature 1988; 240: 64-66.
23. Kieny MP, Lathe R, Rivière Y, Doit K, Schmitt S, Girard M, Montagnier L, Lecocq JP. Improved antigenicity of the HIV env protein by cleavage site removal. Protein Eng 1988; 2: 210-225.
24. Rautmann G, Kieny MP, Brandely R, Dott K, Girard M, Montagnier L, Lecocq JP. HIV-1 core proteins expressed from recombinant vaccinia viruses. AIDS Res Hum Retroviruses 1989; 5: 147-154.
25. Guy B, Kieny MP, Rivière Y, Le Peuch C, Dott K, Girard M, Montagnier L, Lecocq JP. HIV F/3' orf encode a phosphorylated GTP-binding protein resembling an oncogene product. Naturel987; 330: 266-269.
26. Center for Disease Control. Revision of CDC surveillance case definition for acquired immunodeficiency syndrome. MMWR 1987; 36: 1S-14S.
27. Gotch FM, Nixon DF, Alp N, McMichael AJ, Borysiewicz LK. High frequency of memory and effector gag specific cytotoxic T lymphocytes in HIV seropositive individuals. Int Immunol 1990; 2: 707-712.
28. LittauaRA, Oldstone BA, Takeda A, Debouck C, Wong JT, Tanzon CU, Moss B, Kiewits F, Ennis FA. An HLA-C restricted CD8+ cytotoxic T lymphocyte clone recognizes a highly conserved epitope on human immunodeficiency virus type 1 gag. J Virol 1991; 65:4051-4056.
29. Lamhamedi-Cherradi S, Culmann-Penciolelli B, Guy B, Kieny MP, Dreyfus F, Saimot AG, Sereni D, Sicard D, Levy JP, Gomard E. Qualitative and quantitative analysis of human cytotoxic T-lymphocyte responses to HIV-1 proteins. AIDS 1992; 6: 1249-1258.
30. Nixon DF, McMichael AJ. Cytotoxic T-cell recognition of HIV proteins and peptides. AIDS 1991; 9: 1049-1060.
31. Langlade-Demoyen P, Ngo-Giang-Huong N, Ferchal F, Oksenhendler E. Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients. J Clin Invest 1994; 93: 1293-1297.
32. Hoffenbach A, Langlade-Demoyen P, Dadaglio G, Vilmer E, Michel F, Mayaud C, Autran B, Plata F. Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans. J Immunol 1989; 142: 452-462.
33. Carmichael A, Jin X, Sissons P, Borysiewicz L. Quantitative analysis of the human immunodeficiency virus type l (HIV-1 )-specific cytotoxic T lymphocyte (CTL) responses at different stages of HIV-1 infection: differential CTL responses to HIV-1 and EpsteinBarr virus in late disease. J Exp Med 1993; 177: 249-256.
34. Connor RI, Mohri H, Cao Y, Ho DD. Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in HIV-1 infected individuals. J Virol 1993; 67: 1772-1777.
35. Fauci AS. Immunopathogenesis of HIV infection. J Acq Immune Defic Syndr 1993; 6: 655-662.
36. Couillin I, Culmann-Penciolelli B, Gomard E, Levy JP, Guillet JG, Saragosti S. Impaired CTL recognition due to genetic variations in the main immunogenic region of HIV-1 nef protein. J Exp Med 1994; 180: 1129-1134.
37. Koup RA. Virus escape from CTL recognition. J Exp Med 1994; 180: 779-782.
38. Phillips RE, Rowland-Jones S, Nixon DF, Gotch FM, Edwards JP, Ogunlesi AO, Elvin JG, Rothbard JA, Bangham CRM, Rizza CR, McMichael AJ. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 1991; 354: 453-459.
39. Dai LC, West K, Littaua R, Takahashi K, Ennis FA. Mutation of the human immunodeficiency virus type 1 at amino acid 585 on gp 41 results in loss of killing by CD8+ A24-restricted cytotoxic T lymphocytes. J Virol 1992; 66: 3151-3154.
40. Young JAT. HIV and HLA similarity. Naturel988; 333: 215 (letter).
41. Golding H, Robey FA, Gates III FT, Linder W, Beinin PR, Huffman T, Golding B. Identification of homologous regions in human immunodeficiency virus 1 gp 41 and human MHC class II beta 1 domain. 1. Monoclonal antibodies against the gp 41 derived peptide and patients sera react with natural HLA class antigens, suggesting a role for autoimmunity in the pathogenesis acquired immune deficiency syndrome. J Exp Med 1988; 167: 914-923.
42. Mager DL, Freeman JD. Human endogenous retrovirus-like genome with type C pol sequences and gag sequences related to human T-cell lymphotropic viruses. J Virol 1987:61:4060-4066.
43. Zerhouni B, Touraine J-L. Human immunodeficiency virus (HlV)-specific cytotoxic T lymphocytes in persons exposed through sexual contact with HIV-infected patients. J Acq Immune Defic Syndr (in press).
44. Zerhouni B, Sanhadji K, Kehrli L, Livrozet JM, Touraine J-L. Interleukin (IL)-2 deficiency aggravates the defect of natural killer cell activity in AIDS patients. Thymus (in press).